Search Results - "O'Leary, Valerie Bríd"
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Enhanced Extracellular Transfer of HLA-DQ Activates CD3 + Lymphocytes towards Compromised Treg Induction in Celiac Disease
Published in International journal of molecular sciences (29-05-2022)“…Celiac disease (CeD) manifests with autoimmune intestinal inflammation from gluten and genetic predisposition linked to human leukocyte antigen class-II…”
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Published in Trends in genetics (01-11-2020)Get full text
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PARTICLE - a triplex-forming long ncRNA regulates locus specific methylation in response to low dose irradiation
Published in Cell reports (Cambridge) (21-04-2015)“…Exposure to low dose irradiation causes transiently elevated expression of a long ncRNA PARTICLE (Gene PARTICL- 'Promoter of MAT2A-Antisense RadiaTion Induced…”
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Unpacking Pandora From Its Box: Deciphering the Molecular Basis of the SARS-CoV-2 Coronavirus
Published in International journal of molecular sciences (31-12-2020)“…An enigmatic localized pneumonia escalated into a worldwide COVID-19 pandemic from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This review…”
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Can Arginase Inhibitors Be the Answer to Therapeutic Challenges in Alzheimer's Disease?
Published in Neurotherapeutics (01-10-2018)“…While the extensive hunt for therapeutics combating Alzheimer's disease (AD) has fallen short of delivering effective treatments, breakthroughs towards…”
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lncRNA Biomarkers of Glioblastoma Multiforme
Published in Biomedicines (01-05-2024)“…Long noncoding RNAs (lncRNAs) are RNA molecules of 200 nucleotides or more in length that are not translated into proteins. Their expression is…”
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PARTICLE triplexes cluster in the tumor suppressor WWOX and may extend throughout the human genome
Published in Scientific reports (02-08-2017)“…The long non-coding RNA PARTICLE (Gene PARTICL - ‘ P romoter of MAT2A - A ntisense R adia T ion I nduced C irculating L ncRNA) partakes in triple helix…”
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Long non-coding RNA PARTICLE bridges histone and DNA methylation
Published in Scientific reports (11-05-2017)“…PARTICLE (Gene PARTICL - ‘ P romoter of MAT2A - A ntisense R adia T ion I nduced C irculating L ncRNA) expression is transiently elevated following low dose…”
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Biomolecules to Biomarkers? U87MG Marker Evaluation on the Path towards Glioblastoma Multiforme Pathogenesis
Published in Pharmaceutics (01-01-2024)“…The heterogeneity of the glioma subtype glioblastoma multiforme (GBM) challenges effective neuropathological treatment. The reliance on in vitro studies and…”
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The Immunological Epigenetic Landscape of the Human Life Trajectory
Published in Biomedicines (01-11-2022)“…Adaptive immunity changes over an individual’s lifetime, maturing by adulthood and diminishing with old age. Epigenetic mechanisms involving DNA and histone…”
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All-Trans Retinoic Acid Fosters the Multifarious U87MG Cell Line as a Model of Glioblastoma
Published in Brain sciences (18-06-2021)“…Glioblastoma multiforme (GBM) is a primary brain cancer of poor prognosis, with existing treatments remaining essentially palliative. Current GBM therapy fails…”
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COMIRESTROKE—A clinical study protocol for monitoring clinical effect and molecular biological readouts of COMprehensive Intensive REhabilitation program after STROKE: A four-arm parallel-group randomized double blinded controlled trial with a longitudinal design
Published in Frontiers in neurology (01-11-2022)“…IntroductionWhile the role of physiotherapy as part of a comprehensive inpatient rehabilitation is indisputable, clear evidence concerning the effectiveness of…”
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Cerebellar demyelination and neurodegeneration associated with mTORC1 hyperactivity may contribute to the developmental onset of autism‐like neurobehavioral phenotype in a rat model
Published in Autism research (01-05-2022)“…The cerebellum hosts more than half of all neurons of the human brain, with their organized activity playing a key role in coordinating motor functions…”
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The circRNA interactome-innovative hallmarks of the intra- and extracellular radiation response
Published in Oncotarget (03-10-2017)“…Generated by Quaking (QKI), circular RNAs (circRNAs) are newly recognised non-coding RNA (ncRNA) members characterised by tissue specificity, increased…”
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Celiac Disease Defined by Over-Sensitivity to Gliadin Activation and Superior Antigen Presentation of Dendritic Cells
Published in International journal of molecular sciences (15-09-2021)“…The autoimmune condition, Celiac Disease (CeD), displays broad clinical symptoms due to gluten exposure. Its genetic association with DQ variants in the human…”
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The long non-coding RNA PARTICLE is associated with WWOX and the absence of FRA16D breakage in osteosarcoma patients
Published in Oncotarget (20-10-2017)“…Breakage of the fragile site FRA16D disrupts the (WW Domain Containing Oxidoreductase) tumor suppressor gene in osteosarcoma. However, the frequency of…”
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