Search Results - "O'Leary, Valerie B"

Amyloid Plaques of Alzheimer’s Disease as Hotspots of Glutamatergic Activity by Ovsepian, Saak V., O’Leary, Valerie B., Zaborszky, Laszlo, Ntziachristos, Vasilis, Dolly, J. Oliver

“…Deposition of amyloid plaques in limbic and associative cortices is amongst the most recognized histopathologic hallmarks of Alzheimer’s disease. Despite…”
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Genome‐wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma by Smida, Jan, Xu, Hongen, Zhang, Yanping, Baumhoer, Daniel, Ribi, Sebastian, Kovac, Michal, von Luettichau, Irene, Bielack, Stefan, O'Leary, Valerie B., Leib‐Mösch, Christine, Frishman, Dmitrij, Nathrath, Michaela

“…Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. It is characterized by highly complex karyotypes with structural…”
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Mainstream psychiatry reinstates therapeutic ventures of the remote past by Ovsepian, Saak V., O’Leary, Valerie B., Hoschl, Cyril

“…•Gut microbiome restocking and afterbirth consumption are widespread in wildlife.•Faecal transplants (FT) and placental pills (PP) have received much medical…”
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Integrated phylogeny of the human brain and pathobiology of Alzheimer’s disease: A unifying hypothesis by Ovsepian, Saak V., O’Leary, Valerie B., Hoschl, Cyril, Zaborszky, Laszlo

“…•Alzheimer’s disease is prevalent in humans but not in other mammals, including primates.•Pathological alterations target evolutionary most progressive and…”
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Neuronal activity and amyloid plaque pathology: an update by Ovsepian, Saak V, O'Leary, Valerie B

“…A breakthrough in Alzheimer's disease (AD) research came with the discovery of the link between activity-dependent release of amyloid-β (Aβ) from neurons and…”
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Cholinergic Mechanisms in the Cerebral Cortex: Beyond Synaptic Transmission by Ovsepian, Saak V., O’Leary, Valerie B., Zaborszky, Laszlo

“…Functional overviews of cholinergic mechanisms in the cerebral cortex have traditionally focused on the release of acetylcholine with modulator and transmitter…”
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The Ups and Downs of BACE1: Walking a Fine Line between Neurocognitive and Other Psychiatric Symptoms of Alzheimer’s Disease by Ovsepian, Saak V., Horacek, Jiri, O’Leary, Valerie B., Hoschl, Cyril

“…Although neurocognitive deficit is the best-recognized indicator of Alzheimer’s disease (AD), psychotic and other noncognitive symptoms are the prime cause of…”
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Neurobiology and therapeutic utility of neurotoxins targeting postsynaptic mechanisms of neuromuscular transmission by Ayvazyan, Naira M., O’Leary, Valerie B., Dolly, J. Oliver, Ovsepian, Saak V.

“…•Mechanisms of neurotransmission at the neuromuscular junction (NMJ).•Neurobiology of neurotoxins targeting post-synaptic mechanisms at the NMJ.•Therapeutic…”
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Neurobiology and therapeutic applications of neurotoxins targeting transmitter release by Ovsepian, Saak V., O’Leary, Valerie B., Ayvazyan, Naira M., Al-Sabi, Ahmed, Ntziachristos, Vasilis, Dolly, James O.

“…Synaptic transmission is a fundamental neurobiological process enabling exchange of signals between neurons as well as neurons and their non-neuronal…”
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Spatial and Spectral Mapping and Decomposition of Neural Dynamics and Organization of the Mouse Brain with Multispectral Optoacoustic Tomography by Olefir, Ivan, Ghazaryan, Ara, Yang, Hong, Malekzadeh-Najafabadi, Jaber, Glasl, Sarah, Symvoulidis, Panagiotis, O’Leary, Valerie B., Sergiadis, George, Ntziachristos, Vasilis, Ovsepian, Saak V.

“…In traditional optical imaging, limited light penetration constrains high-resolution interrogation to tissue surfaces. Optoacoustic imaging combines the superb…”
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Alleviation of Trigeminal Nociception Using p75 Neurotrophin Receptor Targeted Lentiviral Interference Therapy by O’Leary, Valerie B., O’Connell, Marie, Antyborzec, Inga, Ntziachristos, Vasilis, Oliver Dolly, J., Ovsepian, Saak V.

“…Acute and chronic trigeminal (TG) neuropathies are the cause of considerable distress, with limited treatments available at present. Nociceptive neurons…”
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Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat by O'Leary, Valerie B, Marchetti, Christine M, Krishnan, Raj K, Stetzer, Bradley P, Gonzalez, Frank, Kirwan, John P

“…1 Schwartz Center for Metabolism and Nutrition, and Departments of 2 Medicine, 3 Physiology, 4 Nutrition, and 5 Reproductive Biology, Case Western Reserve…”
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Ageing perspective on cognitive outcomes from reproductive hormone adjustments by Zhang, Grace, Devo, Perry, O'Leary, Valerie B, Ovsepian, Saak V

“…In addition to primary reproductive functions, gonadal hormones play an important role in an array of neural mechanisms across the human lifespan. The…”
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Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons by Ovsepian, Saak V., Antyborzec, Inga, O’Leary, Valerie B., Zaborszky, Laszlo, Herms, Jochen, Oliver Dolly, J.

“…A fascinating yet perhaps overlooked trait of the p75 neurotrophin receptor (p75 NTR ) is its ability to bind ligands with no obvious neurotrophic function…”
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Low-Affinity Neurotrophin Receptor p75 Promotes the Transduction of Targeted Lentiviral Vectors to Cholinergic Neurons of Rat Basal Forebrain by Antyborzec, Inga, O’Leary, Valerie B., Dolly, James O., Ovsepian, Saak V.

“…Basal forebrain cholinergic neurons (BFCNs) are one of the most affected neuronal types in Alzheimer’s disease (AD), with their extensive loss documented at…”
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Internalization and retrograde axonal trafficking of tetanus toxin in motor neurons and trans-synaptic propagation at central synapses exceed those of its C-terminal-binding fragments by Ovespian, Saak V., Bodeker, MacDara, O’Leary, Valerie B., Lawrence, Gary W., Oliver Dolly, J.

“…The prominent tropism of tetanus toxin (TeTx) towards peripheral nerves with retrograde transport and transfer to central neurons render it an invaluable probe…”
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Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults by Solomon, Thomas P. J, Sistrun, Sakita N, Krishnan, Raj K, Del Aguila, Luis F, Marchetti, Christine M, O'Carroll, Susan M, O'Leary, Valerie B, Kirwan, John P

“…1 Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; 2 Noll Physiological Research Center, Penn State University,…”
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Enhanced adiponectin multimer ratio and skeletal muscle adiponectin receptor expression following exercise training and diet in older insulin-resistant adults by O'Leary, Valerie B, Jorett, Ashley E, Marchetti, Christine M, Gonzalez, Frank, Phillips, Susan A, Ciaraldi, Theodore P, Kirwan, John P

“…Circulating adiponectin is reduced in disorders associated with insulin resistance. This study was conducted to determine whether an exercise/diet intervention…”
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The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity by Kelly, Karen R, Brooks, Latina M, Solomon, Thomas P J, Kashyap, Sangeeta R, O'Leary, Valerie B, Kirwan, John P

“…Aging and obesity are characterized by decreased beta-cell sensitivity and defects in the potentiation of nutrient-stimulated insulin secretion by GIP…”
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Adult Neurogenesis in the Gut, Homeostatic Autoimmunity and Neurodegenerative Disease Biomarkers by Ovsepian, Saak V., O'Leary, Valerie B.

“…•Autoantibodies to neuronal proteins are emerging biomarkers of neurodegenerative diseases.•Mounting data suggests dissociation of autoantibody profiles and…”
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