Search Results - "O'Leary, V B"

Innocuous full-length botulinum neurotoxin targets and promotes the expression of lentiviral vectors in central and autonomic neurons by O'Leary, V B, Ovsepian, S V, Raghunath, A, Huo, Q, Lawrence, G W, Smith, L, Dolly, J O

“…Fragments of botulinum neurotoxin (BoNT) have been explored as potential targeting moieties and carriers of biomolecules into neurons, although with lower…”
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A Polymorphism, R653Q, in the Trifunctional Enzyme Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase/Formyltetrahydrofolate Synthetase Is a Maternal Genetic Risk Factor for Neural Tube Defects: Report of the Birth Defects Research Group by Brody, Lawrence C., Conley, Mary, Cox, Christopher, Kirke, Peadar N., McKeever, Mary P., Mills, James L., Molloy, Anne M., O’Leary, Valerie B., Parle-McDermott, Anne, Scott, John M., Swanson, Deborah A.

“…Women who take folic acid periconceptionally reduce their risk of having a child with a neural tube defect (NTD) by >50%. A variant form of…”
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Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association by O’Leary, Valerie B., Mills, James L., Pangilinan, Faith, Kirke, Peadar N., Cox, Christopher, Conley, Mary, Weiler, Andrea, Peng, Kun, Shane, Barry, Scott, John M., Parle-McDermott, Anne, Molloy, Anne M., Brody, Lawrence C.

“…Methionine synthase reductase (MTRR) regenerates methylated cobalamin levels from the oxidised cob(II)alamin form and in so doing plays a crucial role in…”
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Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat by O'Leary, Valerie B, Marchetti, Christine M, Krishnan, Raj K, Stetzer, Bradley P, Gonzalez, Frank, Kirwan, John P

“…1 Schwartz Center for Metabolism and Nutrition, and Departments of 2 Medicine, 3 Physiology, 4 Nutrition, and 5 Reproductive Biology, Case Western Reserve…”
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Analysis of the human folate receptor β gene for an association with neural tube defects by O’Leary, Valerie B, Mills, James L, Kirke, Peadar N, Parle-McDermott, Anne, Swanson, Deborah A, Weiler, Andrea, Pangilinan, Faith, Conley, Mary, Molloy, Anne M, Lynch, Miriam, Cox, Christopher, Scott, John M, Brody, Lawrence C

“…The folate receptor β (FRβ) gene encodes a receptor that binds and transports 5-methyltetrahydrofolate. FRβ polymorphisms may potentially alter folate delivery…”
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Reduced folate carrier polymorphisms and neural tube defect risk by O’Leary, Valerie B., Pangilinan, Faith, Cox, Christopher, Parle-McDermott, Anne, Conley, Mary, Molloy, Anne M., Kirke, Peadar N., Mills, James L., Brody, Lawrence C., Scott, John M.

“…The reduced folate carrier ( RFCI) is essential for folate transport into cells. Low folate is an important cause of neural tube defects (NTDs), and a…”
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MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae by Parle-McDermott, Anne, Mills, James L., Kirke, Peadar N., Cox, Christopher, Signore, Caroline C., Kirke, Sandra, Molloy, Anne M., O'Leary, Valerie B., Pangilinan, Faith J., O'Herlihy, Colm, Brody, Lawrence C., Scott, John M.

“…This study examined the relationship between folate/homocysteine‐related genetic polymorphisms: MTHFD1 1958G → A (R653Q), MTHFR 677C → T (A222V), MTHFR 1298A →…”
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Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population by Swanson, Deborah A., Pangilinan, Faith, Mills, James L., Kirke, Peadar N., Conley, Mary, Weiler, Andrea, Frey, Tiffany, Parle-McDermott, Anne, O'Leary, Valerie B., Seltzer, Rebecca R., Moynihan, Kathryn A., Molloy, Anne M., Burke, Helen, Scott, John M., Brody, Lawrence C.

“…BACKGROUND Decreased maternal folate levels are associated with having a child with a neural tube defect (NTD), and periconceptual folic acid supplementation…”
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Analysis of the MTHFR 1298A→C and 677C→T polymorphisms as risk factors for neural tube defects by Parle-McDermott, Anne, Mills, James L, Kirke, Peadar N, O'Leary, Valerie B, Swanson, Deborah A, Pangilinan, Faith, Conley, Mary, Molloy, Anne M, Cox, Christopher, Scott, John M, Brody, Lawrence C

“…The thermolabile variant (677TT) of methylenetetrahydrofolate reductase (MTHFR) is a known risk factor for neural tube defects (NTDs). The relationship between…”
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Screening for new MTHFR polymorphisms and NTD risk by O'Leary, Valerie B., Mills, James L., Parle-McDermott, Anne, Pangilinan, Faith, Molloy, Anne M., Cox, Christopher, Weiler, Andrea, Conley, Mary, Kirke, Peadar N., Scott, John M., Brody, Lawrence C.

“…The enzyme, 5,10‐methylenetetrahydrofolate reductase (MTHFR) plays a key role in cellular folate metabolism. The A222V (677C‐>T) polymorphism is a confirmed…”
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Alleviation of Trigeminal Nociception Using p75 Neurotrophin Receptor Targeted Lentiviral Interference Therapy by O’Leary, Valerie B., O’Connell, Marie, Antyborzec, Inga, Ntziachristos, Vasilis, Oliver Dolly, J., Ovsepian, Saak V.

“…Acute and chronic trigeminal (TG) neuropathies are the cause of considerable distress, with limited treatments available at present. Nociceptive neurons…”
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Polymorphisms within the vitamin B 12 dependent methylmalonyl-coA mutase are not risk factors for neural tube defects by Parle-McDermott, Anne, McManus, Edward J, Mills, James L, O’Leary, Valerie B, Pangilinan, Faith, Cox, Christopher, Weiler, Andrea, Molloy, Anne M, Conley, Mary, Watson, Deborah, Scott, John M, Brody, Lawrence C, Kirke, Peadar N

“…Methionine synthase and methylmalonyl-CoA mutase (mutase) are the only two known vitamin B 12 (B 12) dependent enzymes in humans. A lower level of B 12 has…”
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MTRR and MTHFR polymorphism: Link to Down syndrome? by O'Leary, Valerie B., Parle-McDermott, Anne, Molloy, Anne M., Kirke, Peadar N., Johnson, Zachary, Conley, Mary, Scott, John M., Mills, James L.

“…Polymorphisms in genes encoding the folate metabolizing enzymes methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase reductase (MTRR A66G)…”
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