Search Results - "O'Leary, Kathleen A."

Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade by Zhang, Ying, Sriramaneni, Raghava N., Clark, Paul A., Jagodinsky, Justin C., Ye, Mingzhou, Jin, Wonjong, Wang, Yuyuan, Bates, Amber, Kerr, Caroline P., Le, Trang, Allawi, Raad, Wang, Xiuxiu, Xie, Ruosen, Havighurst, Thomas C., Chakravarty, Ishan, Rakhmilevich, Alexander L., O’Leary, Kathleen A., Schuler, Linda A., Sondel, Paul M., Kim, Kyungmann, Gong, Shaoqin, Morris, Zachary S.

“…Radiation therapy (RT) activates an in situ vaccine effect when combined with immune checkpoint blockade (ICB), yet this effect may be limited because RT does…”
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Elevated collagen-I augments tumor progressive signals, intravasation and metastasis of prolactin-induced estrogen receptor alpha positive mammary tumor cells by Barcus, Craig E, O'Leary, Kathleen A, Brockman, Jennifer L, Rugowski, Debra E, Liu, Yuming, Garcia, Nancy, Yu, Menggang, Keely, Patricia J, Eliceiri, Kevin W, Schuler, Linda A

“…The development and progression of estrogen receptor alpha positive (ERα+) breast cancer has been linked epidemiologically to prolactin. However, activation of…”
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Prolactin: The Third Hormone in Breast Cancer by Schuler, Linda A., O’Leary, Kathleen A.

“…Prolactin coordinates with the ovarian steroids to orchestrate mammary development and lactation, culminating in nourishment and an increasingly appreciated…”
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Dynamic interactions between the extracellular matrix and estrogen activity in progression of ER+ breast cancer by Jallow, Fatou, O’Leary, Kathleen A., Rugowski, Debra E., Guerrero, Jorge F., Ponik, Suzanne M., Schuler, Linda A.

“…Metastatic, antiestrogen resistant estrogen receptor α positive (ER+) breast cancer is the leading cause of breast cancer deaths in USA women. While studies…”
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High collagen density augments mTOR-dependent cancer stem cells in ERα+ mammary carcinomas, and increases mTOR-independent lung metastases by Shea, Michael P., O'Leary, Kathleen A., Wegner, Kyle A., Vezina, Chad M., Schuler, Linda A.

“…Metastatic estrogen receptor alpha positive (ERα+) cancers account for most breast cancer mortality. Cancer stem cells (CSCs) and dense/stiff extracellular…”
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Prolactin synergizes with canonical Wnt signals to drive development of ER+ mammary tumors via activation of the Notch pathway by O'Leary, Kathleen A., Rugowski, Debra E., Shea, Michael P., Sullivan, Ruth, Moser, Amy R., Schuler, Linda A.

“…Prolactin (PRL) cooperates with other factors to orchestrate mammary development and lactation, and is epidemiologically linked to higher risk for breast…”
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Estrogen receptor blockade and radiation therapy cooperate to enhance the response of immunologically cold ER+ breast cancer to immunotherapy by O'Leary, Kathleen A, Bates, Amber M, Jin, Won Jong, Burkel, Brian M, Sriramaneni, Raghava N, Emma, Sarah E, Nystuen, Erin J, Sumiec, Elizabeth G, Ponik, Suzanne M, Morris, Zachary S, Schuler, Linda A

“…Most patients with estrogen receptor positive (ER+) breast cancer do not respond to immune checkpoint inhibition (ICI); the tumor microenvironment (TME) of…”
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A Spontaneous Aggressive ERα+ Mammary Tumor Model Is Driven by Kras Activation by Campbell, Katie M., O’Leary, Kathleen A., Rugowski, Debra E., Mulligan, William A., Barnell, Erica K., Skidmore, Zachary L., Krysiak, Kilannin, Griffith, Malachi, Schuler, Linda A., Griffith, Obi L.

“…The NRL-PRL murine model, defined by mammary-selective transgenic rat prolactin ligand rPrl expression, establishes spontaneous ER+ mammary tumors in…”
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Modeling prolactin actions in breast cancer in vivo: insights from the NRL-PRL mouse by O'Leary, Kathleen A, Shea, Michael P, Schuler, Linda A

“…Elevated exposure to prolactin (PRL) is epidemiologically associated with an increased risk of aggressive ER+ breast cancer. To understand the underlying…”
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Prolactin Alters the Mammary Epithelial Hierarchy, Increasing Progenitors and Facilitating Ovarian Steroid Action by O'Leary, Kathleen A., Shea, Michael P., Salituro, Stephanie, Blohm, Courtney E., Schuler, Linda A.

“…Hormones drive mammary development and function and play critical roles in breast cancer. Epidemiologic studies link prolactin (PRL) to increased risk for…”
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mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation by Mendrysa, Susan M., McElwee, Matthew K., Michalowski, Jennifer, O'Leary, Kathleen A., Young, Karen M., Perry, Mary Ellen

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Association of Multiple Developmental Defects and Embryonic Lethality with Loss of Microsomal NADPH-Cytochrome P450 Oxidoreductase by Shen, Anna L., O'Leary, Kathleen A., Kasper, Charles B.

“…The microsomal flavoprotein NADPH-cytochrome P450 oxidoreductase (CYPOR) is believed to function as the primary, if not sole, electron donor for the microsomal…”
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Does the presence of significant risk factors affect perioperative outcomes after robot‐assisted radical cystectomy? by Butt, Zubair M., Fazili, Anees, Tan, Wei, Wilding, Gregory E., Filadora, Victor, Kim, Hyung L., Mohler, James L., O’Leary, Kathleen A., Guru, Khurshid A.

“…OBJECTIVE To evaluate the effect of preoperative risk factors on perioperative outcomes up to 3 months after robot‐assisted radical cystectomy (RARC), as RC…”
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The PPCD1 mouse: characterization of a mouse model for posterior polymorphous corneal dystrophy and identification of a candidate gene by Shen, Anna L, O'Leary, Kathleen A, Dubielzig, Richard R, Drinkwater, Norman, Murphy, Christopher J, Kasper, Charles B, Bradfield, Christopher A

“…The PPCD1 mouse, a spontaneous mutant that arose in our mouse colony, is characterized by an enlarged anterior chamber resulting from metaplasia of the corneal…”
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Antiestrogen Therapy Increases Plasticity and Cancer Stemness of Prolactin-Induced ERα + Mammary Carcinomas by Shea, Michael P, O'Leary, Kathleen A, Fakhraldeen, Saja A, Goffin, Vincent, Friedl, Andreas, Wisinski, Kari B, Alexander, Caroline M, Schuler, Linda A

“…Although antiestrogen therapies are successful in many patients with estrogen receptor alpha-positive (ERα ) breast cancer, 25% to 40% fail to respond…”
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Tumor suppression and normal aging in mice with constitutively high p53 activity by Mendrysa, Susan M, O'Leary, Kathleen A, McElwee, Matthew K, Michalowski, Jennifer, Eisenman, Robert N, Powell, Douglas A, Perry, Mary Ellen

“…The p53 inhibitor murine double-minute gene 2 (Mdm2) is a target for potential cancer therapies, however increased p53 function can be lethal. To directly…”
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Prolactin Activates ERα in the Absence of Ligand in Female Mammary Development and Carcinogenesis in Vivo by O'Leary, Kathleen A, Jallow, Fatou, Rugowski, Debra E, Sullivan, Ruth, Sinkevicius, Kerstin W, Greene, Geoffrey L, Schuler, Linda A

“…Resistance of estrogen receptor positive (ERα+) breast cancers to antiestrogens is a major factor in the mortality of this disease. Although activation of ERα…”
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Prolactin Promotes Mammary Pathogenesis Independently from Cyclin D1 by Asher, Jennifer M, O'Leary, Kathleen A, Rugowski, Debra E, Arendt, Lisa M, Schuler, Linda A

“…Epidemiological and experimental studies have revealed an important role for prolactin (PRL) in breast cancer. Cyclin D1 is a major downstream target of PRL in…”
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Social isolation reduces mammary development, tumor incidence, and expression of epigenetic regulators in wild-type and p53-heterozygotic mice by Hasen, Nina S, O'Leary, Kathleen A, Auger, Anthony P, Schuler, Linda A

“…Chronic stress is associated with more rapid tumor progression, and recent evidence suggests that stress may contribute to social and ethnic disparities in the…”
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Mdm2 regulates p53 independently of p19(ARF) in homeostatic tissues by O'Leary, Kathleen A, Mendrysa, Susan M, Vaccaro, Abram, Perry, Mary Ellen

“…Tumor suppressor proteins must be exquisitely regulated since they can induce cell death while preventing cancer. For example, the p19(ARF) tumor suppressor…”
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