Search Results - "O'Leary, Dennis DM"

Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas by Zembrzycki, Andreas, Stocker, Adam M, Leingärtner, Axel, Sahara, Setsuko, Chou, Shen-Ju, Kalatsky, Valery, May, Scott R, Stryker, Michael P, O'Leary, Dennis Dm

“…In mammals, the neocortical layout consists of few modality-specific primary sensory areas and a multitude of higher order ones. Abnormal layout of cortical…”
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Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations by Li, Hao, Chou, Shen-Ju, Hamasaki, Tadashi, Perez-Garcia, Carlos G, O'Leary, Dennis D M

“…Cortical GABAergic interneurons (INs) are generated in the medial ganglionic eminence (MGE) and migrate tangentially into cortex. Because most, if not all,…”
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Genetic regulation of arealization of the neocortex by O’Leary, Dennis DM, Sahara, Setsuko

“…Arealization of the neocortex is controlled by a regulatory hierarchy beginning with morphogens secreted from patterning centers positioned at the perimeter of…”
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Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning by Sahara, Setsuko, Kawakami, Yasuhiko, Izpisua Belmonte, Juan Carlos, O'Leary, Dennis D M

“…Telencephalic patterning centers, defined by the discrete expression domains of distinct morphogens, Fgfs in the commissural plate (CoP), Wnts and Bmps in the…”
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A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype by Dwyer, Noelle D, Manning, Danielle K, Moran, Jennifer L, Mudbhary, Raksha, Fleming, Michael S, Favero, Carlita B, Vock, Vita M, O'Leary, Dennis D M, Walsh, Christopher A, Beier, David R

“…The dorsal thalamus acts as a gateway and modulator for information going to and from the cerebral cortex. This activity requires the formation of reciprocal…”
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Eph receptors and ephrins in neural development by O'Leary, Dennis DM, Wilkinson, David G

“…Ephrins, ligands for the Eph family of receptor tyrosine kinases, are pivotal players in many developmental phenomena in both the central and peripheral…”
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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases by O'Leary, Dennis D. M, Tessier-Lavigne, Marc, Nikolaev, Anatoly, McLaughlin, Todd

“…Naturally occurring axonal pruning and neuronal cell death help to sculpt neuronal connections during development, but their mechanistic basis remains poorly…”
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Area Patterning of the Mammalian Cortex by O'Leary, Dennis D.M., Chou, Shen-Ju, Sahara, Setsuko

“…Here we describe mechanisms regulating area patterning of developing mammalian neocortex, referred to as arealization. Current findings indicate an interplay…”
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Fgf10 Regulates Transition Period of Cortical Stem Cell Differentiation to Radial Glia Controlling Generation of Neurons and Basal Progenitors by Sahara, Setsuko, O'Leary, Dennis D.M.

“…Radial glia (RG), the progenitors of cortical neurons and basal progenitors (BPs), differentiate from neuroepithelial cells (NCs) with stem cell properties. We…”
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A caspase cascade regulating developmental axon degeneration by Simon, David J, Weimer, Robby M, McLaughlin, Todd, Kallop, Dara, Stanger, Karen, Yang, Jing, O'Leary, Dennis D M, Hannoush, Rami N, Tessier-Lavigne, Marc

“…Axon degeneration initiated by trophic factor withdrawal shares many features with programmed cell death, but many prior studies discounted a role for caspases…”
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Geniculocortical Input Drives Genetic Distinctions Between Primary and Higher-Order Visual Areas by Chou, Shen-Ju, Babot, Zoila, Leingärtner, Axel, Studer, Michele, Nakagawa, Yasushi, O'Leary, Dennis D. M.

“…Studies of area patterning of the neocortex have focused on primary areas, concluding that the primary visual area, V1, is specified by transcription factors…”
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In Vivo Expression of a Light-Activatable Potassium Channel Using Unnatural Amino Acids by Kang, Ji-Yong, Kawaguchi, Daichi, Coin, Irene, Xiang, Zheng, O’Leary, Dennis D.M., Slesinger, Paul A., Wang, Lei

“…Optical control of protein function provides excellent spatial-temporal resolution for studying proteins in situ. Although light-sensitive exogenous proteins…”
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Role for Lhx2 in corticogenesis through regulation of progenitor differentiation by Chou, Shen-Ju, O'Leary, Dennis D.M.

“…The neocortex represents the brain region that has undergone a major increase in its relative size during the course of mammalian evolution. The larger cortex…”
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Retinotopic Map Refinement Requires Spontaneous Retinal Waves during a Brief Critical Period of Development by McLaughlin, Todd, Torborg, Christine L., Feller, Marla B., O'Leary, Dennis D.M.

“…During retinocollicular map development, spontaneous waves of action potentials spread across the retina, correlating activity among neighboring retinal…”
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Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase by Olsen, Olav, Kallop, Dara Y, McLaughlin, Todd, Huntwork-Rodriguez, Sarah, Wu, Zhuhao, Duggan, Cynthia D, Simon, David J, Lu, Yanmei, Easley-Neal, Courtney, Takeda, Kentaro, Hass, Philip E, Jaworski, Alexander, O'Leary, Dennis D M, Weimer, Robby M, Tessier-Lavigne, Marc

“…In the developing brain, initial neuronal projections are formed through extensive growth and branching of developing axons, but many branches are later pruned…”
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EMX2 Regulates Sizes and Positioning of the Primary Sensory and Motor Areas in Neocortex by Direct Specification of Cortical Progenitors by Hamasaki, Tadashi, Leingärtner, Axel, Ringstedt, Thomas, O'Leary, Dennis D.M.

“…Genetic studies of neocortical area patterning are limited, because mice deficient for candidate regulatory genes die before areas emerge and have other…”
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Regulation of axial patterning of the retina and its topographic mapping in the brain by McLaughlin, Todd, Hindges, Robert, O’Leary, Dennis DM

“…Topographic maps are a fundamental organizational feature of axonal connections in the brain. A prominent model for studying axial polarity and topographic map…”
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Islet1-mediated activation of the β-catenin pathway is necessary for hindlimb initiation in mice by Kawakami, Yasuhiko, Marti, Merce, Kawakami, Hiroko, Itou, Junji, Quach, Thu, Johnson, Austin, Sahara, Setsuko, O'Leary, Dennis D M, Nakagawa, Yasushi, Lewandoski, Mark, Pfaff, Samuel, Evans, Sylvia M, Izpisua Belmonte, Juan Carlos

“…The transcriptional basis of vertebrate limb initiation, which is a well-studied system for the initiation of organogenesis, remains elusive. Specifically,…”
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EphB Forward Signaling Controls Directional Branch Extension and Arborization Required for Dorsal-Ventral Retinotopic Mapping by Hindges, Robert, McLaughlin, Todd, Genoud, Nicolas, Henkemeyer, Mark, O'Leary, Dennis D.M

“…We report that EphB receptors direct unique axonal behaviors required for mapping the dorsal-ventral (D-V) retinal axis along the lateral-medial (L-M) axis of…”
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Fgf10 Regulates Transition Period of Cortical Stem Cell Differentiation to Radial Glia Controlling Generation of Neurons and Basal Progenitors by Sahara, Setsuko, O'Leary, Dennis DM

“…Radial glia (RG), the progenitors of cortical neurons and basal progenitors (BPs), differentiate from neuroepithelial cells (NCs) with stem cell properties. We…”
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