Search Results - "O'Leary, Claire"

Tuft Cells-Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry by O'Leary, Claire E, Schneider, Christoph, Locksley, Richard M

“…Tuft cells-rare solitary chemosensory cells in mucosal epithelia-are undergoing intense scientific scrutiny fueled by recent discovery of unsuspected…”
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A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling by Schneider, Christoph, O’Leary, Claire E., von Moltke, Jakob, Liang, Hong-Erh, Ang, Qi Yan, Turnbaugh, Peter J., Radhakrishnan, Sridhar, Pellizzon, Michael, Ma, Averil, Locksley, Richard M.

“…The small intestinal tuft cell-ILC2 circuit mediates epithelial responses to intestinal helminths and protists by tuft cell chemosensory-like sensing and…”
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The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice by Deshmukh, Hitesh S, Liu, Yuhong, Menkiti, Ogechukwu R, Mei, Junjie, Dai, Ning, O'Leary, Claire E, Oliver, Paula M, Kolls, Jay K, Weiser, Jeffrey N, Worthen, G Scott

“…Here, Hitesh S. Deshmukh et al. report that in neonates, establishment of the intestinal microbiota is associated with neutrophil development…”
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New insights into tuft cell formation: Implications for structure–function relationships by O'Leary, Claire E., Ma, Zhibo, Culpepper, Taylor, Novak, Sammy Weiser, DelGiorno, Kathleen E.

“…Tuft cells are sentinel chemosensory cells that monitor the lumen of hollow organs for noxious or infectious stimuli and respond with disease- and…”
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Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage by Kotas, Maya E, O'Leary, Claire E, Locksley, Richard M

“…Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and luminal exposures but converge on a shared transcriptional…”
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Innate type 2 immunity controls hair follicle commensalism by Demodex mites by Ricardo-Gonzalez, Roberto R., Kotas, Maya E., O’Leary, Claire E., Singh, Katelyn, Damsky, William, Liao, Chang, Arouge, Elizabeth, Tenvooren, Iliana, Marquez, Diana M., Schroeder, Andrew W., Cohen, Jarish N., Fassett, Marlys S., Lee, Jinwoo, Daniel, Scott G., Bittinger, Kyle, Díaz, Roberto Efraín, Fraser, James S., Ali, Niwa, Ansel, K. Mark, Spitzer, Matthew H., Liang, Hong-Erh, Locksley, Richard M.

“…Demodex mites are commensal parasites of hair follicles (HFs). Normally asymptomatic, inflammatory outgrowth of mites can accompany malnutrition, immune…”
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Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease by Layman, Awo Akosua Kesewa, Deng, Guoping, O’Leary, Claire E., Tadros, Samuel, Thomas, Rajan M., Dybas, Joseph M., Moser, Emily K., Wells, Andrew D., Doliba, Nicolai M., Oliver, Paula M.

“…Foxp3 + T regulatory (T reg ) cells suppress immune cell activation and establish normal immune homeostasis. How T reg cells maintain their identity is not…”
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A comparison of changes in drug burden index between older inpatients who fell and people who have not fallen: A case-control study by O'Leary, Claire E T, Wilkinson, Timothy J, Hanger, H Carl

“…Older inpatients who fall are often frail, with multiple co-morbidities and polypharmacy. Although the causes of falls are multifactorial, sedating and…”
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Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation by Riling, Christopher, Kamadurai, Hari, Kumar, Suresh, O'Leary, Claire E., Wu, Kuen-Phon, Manion, Erica E., Ying, Mingjie, Schulman, Brenda A., Oliver, Paula M.

“…Nedd4-family E3 ubiquitin ligases regulate an array of biologic processes. Autoinhibition maintains these catalytic ligases in an inactive state through…”
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A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency by Tordo, Julie, O'Leary, Claire, Antunes, André S L M, Palomar, Nuria, Aldrin-Kirk, Patrick, Basche, Mark, Bennett, Antonette, D'Souza, Zelpha, Gleitz, Hélène, Godwin, Annie, Holley, Rebecca J, Parker, Helen, Liao, Ai Yin, Rouse, Paul, Youshani, Amir Saam, Dridi, Larbi, Martins, Carla, Levade, Thierry, Stacey, Kevin B, Davis, Daniel M, Dyer, Adam, Clément, Nathalie, Björklund, Tomas, Ali, Robin R, Agbandje-McKenna, Mavis, Rahim, Ahad A, Pshezhetsky, Alexey, Waddington, Simon N, Linden, R Michael, Bigger, Brian W, Henckaerts, Els

“…Tordo et al. present a novel AAV gene therapy vector, AAV-TT, which exceeds the current benchmark neurotropic serotypes AAV9 and AAVrh10 and enables…”
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Systemic immune challenge exacerbates neurodegeneration in a model of neurological lysosomal disease by Mandolfo, Oriana, Parker, Helen, Aguado, Èlia, Ishikawa Learmonth, Yuko, Liao, Ai Yin, O’Leary, Claire, Ellison, Stuart, Forte, Gabriella, Taylor, Jessica, Wood, Shaun, Searle, Rachel, Holley, Rebecca J, Boutin, Hervé, Bigger, Brian W

“…Mucopolysaccharidosis type IIIA (MPS IIIA) is a rare paediatric lysosomal storage disorder, caused by the progressive accumulation of heparan sulphate,…”
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Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy by Holley, Rebecca J, Ellison, Stuart M, Fil, Daniel, O'Leary, Claire, McDermott, John, Senthivel, Nishanthi, Langford-Smith, Alexander W W, Wilkinson, Fiona L, D'Souza, Zelpha, Parker, Helen, Liao, Aiyin, Rowlston, Samuel, Gleitz, Hélène F E, Kan, Shih-Hsin, Dickson, Patricia I, Bigger, Brian W

“…There are currently no treatments for mucopolysaccharidosis IIIB. Holley et al. develop a lentiviral-driven stem cell gene therapy in mice that corrects…”
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Intraparenchymal convection enhanced delivery of AAV in sheep to treat Mucopolysaccharidosis IIIC by O'Leary, Claire, Forte, Gabriella, Mitchell, Nadia L, Youshani, Amir Saam, Dyer, Adam, Wellby, Martin P, Russell, Katharina N, Murray, Samantha J, Jolinon, Nelly, Jones, Simon A, Stacey, Kevin, Davis, Daniel M, Henckaerts, Els, Palmer, David N, Kamaly-Asl, Ian, Bigger, Brian W

“…Mucopolysaccharidosis IIIC (MPSIIIC) is one of four Sanfilippo diseases sharing clinical symptoms of severe cognitive decline and shortened lifespan. The…”
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Increased Circulating Chemokines and Macrophage Recruitment in Growing Vestibular Schwannomas by Hannan, Cathal John, Lewis, Daniel, O'Leary, Claire, Waqar, Mueez, Brough, David, Couper, Kevin N, Dyer, Douglas P, Vail, Andy, Heal, Calvin, Macarthur, Joshua, Cooper, Christopher, Hammerbeck-Ward, Charlotte, Evans, D Gareth, Rutherford, Scott A, Lloyd, Simon K, Mackenzie Freeman, Simon Richard, Coope, David John, King, Andrew T, Pathmanaban, Omar Nathan

“…There is evidence that macrophage infiltration in the tumor microenvironment promotes vestibular schwannoma (VS) growth. Efficacy of bevacizumab in…”
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The microenvironment in sporadic and neurofibromatosis type II-related vestibular schwannoma: the same tumor or different? A comparative imaging and neuropathology study by Lewis, Daniel, Donofrio, Carmine A, O'Leary, Claire, Li, Ka-Loh, Zhu, Xiaoping, Williams, Ricky, Djoukhadar, Ibrahim, Agushi, Erjon, Hannan, Cathal J, Stapleton, Emma, Lloyd, Simon K, Freeman, Simon R, Wadeson, Andrea, Rutherford, Scott A, Hammerbeck-Ward, Charlotte, Evans, D Gareth, Jackson, Alan, Pathmanaban, Omar N, Roncaroli, Federico, King, Andrew T, Coope, David J

“…Inflammation and angiogenesis may play a role in the growth of sporadic and neurofibromatosis type 2 (NF2)-related vestibular schwannoma (VS). The similarities…”
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Interrogating the Small Intestine Tuft Cell-ILC2 Circuit Using In Vivo Manipulations by O'Leary, Claire E, Feng, Xiaogang, Cortez, Victor S, Locksley, Richard M, Schneider, Christoph

“…Recent findings position tuft cells as key mediators of intestinal immunity through their production of the cytokine interleukin (IL)-25 and activation of…”
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Non-myeloablative busulfan chimeric mouse models are less pro-inflammatory than head-shielded irradiation for studying immune cell interactions in brain tumours by Youshani, A Saam, Rowlston, Samuel, O'Leary, Claire, Forte, Gabriella, Parker, Helen, Liao, Aiyin, Telfer, Brian, Williams, Kaye, Kamaly-Asl, Ian D, Bigger, Brian W

“…Chimeric mouse models generated via adoptive bone marrow transfer are the foundation for immune cell tracking in neuroinflammation. Chimeras that exhibit low…”
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Brain‐targeted stem cell gene therapy corrects mucopolysaccharidosis type II via multiple mechanisms by Gleitz, Hélène FE, Liao, Ai Yin, Cook, James R, Rowlston, Samuel F, Forte, Gabriella MA, D'Souza, Zelpha, O'Leary, Claire, Holley, Rebecca J, Bigger, Brian W

“…The pediatric lysosomal storage disorder mucopolysaccharidosis type II is caused by mutations in IDS, resulting in accumulation of heparan and dermatan…”
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Bile acid-sensitive tuft cells regulate biliary neutrophil influx by O'Leary, Claire E, Sbierski-Kind, Julia, Kotas, Maya E, Wagner, Johanna C, Liang, Hong-Erh, Schroeder, Andrew W, de Tenorio, Jeshua C, von Moltke, Jakob, Ricardo-Gonzalez, Roberto R, Eckalbar, Walter L, Molofsky, Ari B, Schneider, Christoph, Locksley, Richard M

“…Inflammation and dysfunction of the extrahepatic biliary tree are common causes of human pathology, including gallstones and cholangiocarcinoma. Despite this,…”
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Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: A putative model of gene × environment interaction by Desbonnet, Lieve, O’Tuathaigh, Colm, Clarke, Gerard, O’Leary, Claire, Petit, Emilie, Clarke, Niamh, Tighe, Orna, Lai, Donna, Harvey, Richard, Cryan, John F, Dinan, Timothy G, Waddington, John L

“…Highlight ► These data identify cytokines as a key link between NRG1 and the pathology of schizophrenia, and highlight the importance of early environment in…”
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