Search Results - "O'Leary, Aet"
-
1
Serotonin release by parachloroamphetamine in rats with high and low sociability: High prefrontal release capacity in sociable females
Published in Journal of psychopharmacology (Oxford) (01-11-2024)“…Background: Social behaviour is the expression of one of the most generally accepted independent dimensions of personality. Serotonergic neurotransmission has…”
Get full text
Journal Article -
2
Sex- and cycle-dependent changes in spine density and size in hippocampal CA2 neurons
Published in Scientific reports (28-05-2024)“…Sex hormones affect structural and functional plasticity in the rodent hippocampus. However, hormone levels not only differ between males and females, but also…”
Get full text
Journal Article -
3
Nitric oxide interacts with monoamine oxidase to modulate aggression and anxiety-like behaviour
Published in European neuropsychopharmacology (01-01-2020)“…Nitric oxide (NO) is a gaseous neurotransmitter that has important behavioural functions in the vertebrate brain. In this study we compare the impact of…”
Get full text
Journal Article -
4
A systematic review of preclinical studies exploring the role of insulin signalling in executive function and memory
Published in Neuroscience and biobehavioral reviews (01-12-2023)“…Beside its involvement in somatic dysfunctions, altered insulin signalling constitutes a risk factor for the development of mental disorders like Alzheimer’s…”
Get full text
Journal Article -
5
Synaptic proteome perturbations after maternal immune activation: Identification of embryonic and adult hippocampal changes
Published in Brain, behavior, and immunity (01-10-2024)“…•Poly(I:C)-induced maternal immune activation (MIA) affects the synaptic proteome.•The synaptic proteome of adult MIA offspring is changed in a sex-specific…”
Get full text
Journal Article -
6
Prenatal and postnatal experiences associated with epigenetic changes in the adult mouse brain
Published in Behavioural brain research (01-02-2019)“…To analyze the influences of early-life history on the brain epigenome, the offspring of mouse dams kept in an enriched or standard environment were exposed…”
Get full text
Journal Article -
7
Dissociation of impulsivity and aggression in mice deficient for the ADHD risk gene Adgrl3: Evidence for dopamine transporter dysregulation
Published in Neuropharmacology (15-09-2019)“…Adhesion G protein-coupled receptor L3 (ADGRL3, LPHN3) has putative roles in neuronal migration and synapse function. Various polymorphisms in ADGRL3 have been…”
Get full text
Journal Article -
8
Limited effects of early life manipulations on sex-specific gene expression and behavior in adulthood
Published in Behavioural brain research (02-09-2019)“…•Female CD1 mice had higher fecal corticosterone metabolites (FCM) levels compared to males and this was attenuated by environmental enrichment.•Control…”
Get full text
Journal Article -
9
The evolution of dystonia-like movements in TOR1A rats after transient nerve injury is accompanied by dopaminergic dysregulation and abnormal oscillatory activity of a central motor network
Published in Neurobiology of disease (01-07-2021)“…TOR1A is the most common inherited form of dystonia with still unclear pathophysiology and reduced penetrance of 30–40%. ∆ETorA rats mimic the TOR1A disease by…”
Get full text
Journal Article -
10
The translational genetics of ADHD and related phenotypes in model organisms
Published in Neuroscience and biobehavioral reviews (01-01-2023)“…Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental disorder resulting from the interaction between genetic and…”
Get full text
Journal Article -
11
Antidepressants differentially affect striatal amphetamine-stimulated dopamine and serotonin release in rats with high and low novelty-oriented behaviour
Published in Pharmacological research (01-11-2016)“…[Display omitted] In the studies of depression pathogenesis and antidepressant action, the monoaminergic hypothesis of depression has mainly focused on the…”
Get full text
Journal Article -
12
Challenges with modelling anxiety disorders: a possible hindrance for drug discovery
Published in Expert opinion on drug discovery (03-04-2018)Get more information
Journal Article -
13
Comparison of psychotropic medication use in the Baltic countries
Published in Nordic journal of psychiatry (01-05-2020)“…Purpose: While the pivotal role of pharmacotherapy in psychiatry is universal, significant regional differences exist in drug use patterns. Herewith we compare…”
Get full text
Journal Article -
14
Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury
Published in Acta neuropathologica communications (03-10-2016)“…Isolated generalized dystonia is a central motor network disorder characterized by twisted movements or postures. The most frequent genetic cause is a GAG…”
Get full text
Journal Article -
15
Psycho-social factors associated with mental resilience in the Corona lockdown
Published in Translational psychiatry (21-01-2021)“…The SARS-CoV-2 pandemic is not only a threat to physical health but is also having severe impacts on mental health. Although increases in stress-related…”
Get full text
Journal Article Web Resource -
16
Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis
Published in eLife (14-11-2017)“…Juvenile neuronal ceroid lipofuscinosis (JNCL or Batten disease) caused by mutations in the gene is the most prevalent inherited neurodegenerative disease in…”
Get full text
Journal Article -
17
Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits
Published in Molecular psychiatry (01-11-2022)“…Common variation in the gene encoding the neuron-specific RNA splicing factor RNA Binding Fox-1 Homolog 1 ( RBFOX1 ) has been identified as a risk factor for…”
Get full text
Journal Article -
18
Molecular landscape of the overlap between Alzheimer's disease and somatic insulin-related diseases
Published in Alzheimer's research & therapy (28-10-2024)“…Alzheimer's disease (AD) is a multifactorial disease with both genetic and environmental factors contributing to its etiology. Previous evidence has implicated…”
Get full text
Journal Article -
19
Expression of the ADHD candidate gene Diras2 in the brain
Published in Journal of Neural Transmission (01-06-2018)“…The distinct subgroup of the Ras family member 2 (DIRAS2) gene has been found to be associated with attention-deficit/hyperactivity disorder (ADHD) in one of…”
Get full text
Journal Article -
20
Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders
Published in EBioMedicine (01-09-2021)“…Nitric oxide synthase 1 adaptor protein (NOS1AP; previously named CAPON) is linked to the glutamatergic postsynaptic density through interaction with neuronal…”
Get full text
Journal Article