Search Results - "O'Laughlin, Richard"

A patterned human neural tube model using microfluidic gradients by Xue, Xufeng, Kim, Yung Su, Ponce-Arias, Alfredo-Isaac, O’Laughlin, Richard, Yan, Robin Zhexuan, Kobayashi, Norio, Tshuva, Rami Yair, Tsai, Yu-Hwai, Sun, Shiyu, Zheng, Yi, Liu, Yue, Wong, Frederick C. K., Surani, Azim, Spence, Jason R., Song, Hongjun, Ming, Guo-Li, Reiner, Orly, Fu, Jianping

“…The human nervous system is a highly complex but organized organ. The foundation of its complexity and organization is laid down during regional patterning of…”
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Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis by Paxman, Julie, Zhou, Zhen, O'Laughlin, Richard, Liu, Yuting, Li, Yang, Tian, Wanying, Su, Hetian, Jiang, Yanfei, Holness, Shayna E, Stasiowski, Elizabeth, Tsimring, Lev S, Pillus, Lorraine, Hasty, Jeff, Hao, Nan

“…Chromatin instability and protein homeostasis (proteostasis) stress are two well-established hallmarks of aging, which have been considered largely independent…”
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A programmable fate decision landscape underlies single-cell aging in yeast by Li, Yang, Jiang, Yanfei, Paxman, Julie, O'Laughlin, Richard, Klepin, Stephen, Zhu, Yuelian, Pillus, Lorraine, Tsimring, Lev S, Hasty, Jeff, Hao, Nan

“…Chromatin instability and mitochondrial decline are conserved processes that contribute to cellular aging. Although both processes have been explored…”
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Patterning of brain organoids derived from human pluripotent stem cells by Zhang, Zhijian, O'Laughlin, Richard, Song, Hongjun, Ming, Guo-li

“…The emerging technology of brain organoids deriving from human pluripotent stem cells provides unprecedented opportunities to study human brain development and…”
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Multigenerational silencing dynamics control cell aging by Li, Yang, Jin, Meng, O’Laughlin, Richard, Bittihn, Philip, Tsimring, Lev S., Pillus, Lorraine, Hasty, Jeff, Hao, Nan

“…Cellular aging plays an important role in many diseases, such as cancers, metabolic syndromes, and neurodegenerative disorders. There has been steady progress…”
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Flavin-based metabolic cycles are integral features of growth and division in single yeast cells by Baumgartner, Bridget L., O’Laughlin, Richard, Jin, Meng, Tsimring, Lev S., Hao, Nan, Hasty, Jeff

“…The yeast metabolic cycle (YMC) is a fascinating example of biological organization, in which cells constrain the function of specific genetic, protein and…”
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A Standardized Set of MoClo-Compatible Inducible Promoter Systems for Tunable Gene Expression in Yeast by O’Laughlin, Richard, Tran, Quoc, Lezia, Andrew, Ngamkanjanarat, Wasu, Emmanuele, Philip, Hao, Nan, Hasty, Jeff

“…Small-molecule control of gene expression underlies the function of numerous engineered gene circuits that are capable of environmental sensing, computation,…”
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Fabrication of Microfluidic Devices for Continuously Monitoring Yeast Aging by O'Laughlin, Richard, Forrest, Emerald, Hasty, Jeff, Hao, Nan

“…For several decades, aging in has been studied in hopes of understanding its causes and identifying conserved pathways that also drive aging in multicellular…”
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A Microfluidic Platform for Screening Gene Expression Dynamics across Yeast Strain Libraries by Stasiowski, Elizabeth, O'Laughlin, Richard, Holness, Shayna, Csicsery, Nicholas, Hasty, Jeff, Hao, Nan

“…The relative ease of genetic manipulation in is one of its greatest strengths as a model eukaryotic organism. Researchers have leveraged this quality of the…”
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Divergent Aging of Isogenic Yeast Cells Revealed through Single-Cell Phenotypic Dynamics by Jin, Meng, Li, Yang, O'Laughlin, Richard, Bittihn, Philip, Pillus, Lorraine, Tsimring, Lev S, Hasty, Jeff, Hao, Nan

“…Although genetic mutations that alter organisms' average lifespans have been identified in aging research, our understanding of the dynamic changes during…”
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Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae by O'Laughlin, Richard, Jin, Meng, Li, Yang, Pillus, Lorraine, Tsimring, Lev S., Hasty, Jeff, Hao, Nan

“…Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb to the deteriorating effects of aging, so too comes a host of…”
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Microfluidic Technologies for Investigating Dynamics-Based Regulation in S. cerevisiae by O'Laughlin, Richard

“…Technological advances in molecular biology over the last several decades have enabled researchers to probe the inner workings of living systems at…”
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Failure analysis of surrogate tibial constructs with medium and fast setting bone cements by O’Laughlin, Richard, Abbruzzese, Kevin, Lee, Daniel, Allan, D. Gordon, Paliwal, Manish

“…•Surrogate tibial constructs were tested by subjecting them to cyclic loading.•Fast and medium setting bone cements were used to instrument tibial…”
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WADDINGTON’S LANDSCAPE OF CELL AGING by Hao, Nan, Li, Yang, Jiang, Yanfei, Paxman, Julie, O’Laughlin, Richard, Pillus, Lorraine, Tsimring, Lev, Hasty, Jeff

“…Abstract Cellular aging is a complex process that involves many interwoven molecular processes. Studies in model organisms have identified many individual…”
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Pituitary adenoma in McCune-Albright syndrome: MR demonstration by O'Laughlin, R L, Selinger, S E, Moriarty, P E

“…The magnetic resonance (MR) demonstration of a pituitary adenoma associated with McCune-Albright syndrome is presented. A useful role for routine MR imaging of…”
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Chelation of beta-phenethylbiguanide and other biguanides with copper ion by FOYE, W O, O'LAUGHLIN, R L, DUVALL, R N

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