Search Results - "O'Keefe, Michael B"

Palladium-Catalyzed Dearomative Trimethylenemethane Cycloaddition Reactions by Trost, Barry M, Ehmke, Veronika, O’Keefe, B. Michael, Bringley, Dustin A

“…A general protocol for the palladium-catalyzed dearomative trimethylenemethane [3+2] cyclo­addition reaction with simple nitro­arene substrates is described…”
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Carbonylative Cross-Coupling of ortho-Disubstituted Aryl Iodides. Convenient Synthesis of Sterically Hindered Aryl Ketones by O’Keefe, B. Michael, Simmons, Nicholas, Martin, Stephen F

“…A mild and general protocol for the carbonylative cross-coupling of sterically hindered ortho-disubstituted aryl iodides is reported. Carbonylative…”
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Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys by Mackman, Richard L., Kalla, Rao V., Babusis, Darius, Pitts, Jared, Barrett, Kimberly T., Chun, Kwon, Du Pont, Venice, Rodriguez, Lauren, Moshiri, Jasmine, Xu, Yili, Lee, Michael, Lee, Gary, Bleier, Blake, Nguyen, Anh-Quan, O’Keefe, B. Michael, Ambrosi, Andrea, Cook, Meredith, Yu, Joy, Dempah, Kassibla Elodie, Bunyan, Elaine, Riola, Nicholas C., Lu, Xianghan, Liu, Renmeng, Davie, Ashley, Hsiang, Tien-Ying, Dearing, Justin, Vermillion, Meghan, Gale, Michael, Niedziela-Majka, Anita, Feng, Joy Y., Hedskog, Charlotte, Bilello, John P., Subramanian, Raju, Cihlar, Tomas

“…Remdesivir 1 is an phosphoramidate prodrug that releases the monophosphate of nucleoside GS-441524 (2) into lung cells, thereby forming the bioactive…”
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A Highly Convergent Total Synthesis of Leustroducsin B by Trost, Barry M, Biannic, Berenger, Brindle, Cheyenne S, O’Keefe, B. Michael, Hunter, Thomas J, Ngai, Ming-Yu

“…Leustroducsin B exhibits a large variety of biological activities and unique structural features. An efficient and highly convergent total synthesis of…”
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Facile access to sterically hindered aryl ketones via carbonylative cross-coupling: application to the total synthesis of luteolin by O’Keefe, B. Michael, Simmons, Nicholas, Martin, Stephen F.

“…A general and mild protocol for achieving the carbonylative cross-coupling of sterically hindered, ortho-disubstituted aryl ketones is reported. The…”
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Studies toward the syntheses of pluramycin natural products. The first total synthesis of isokidamycin by O’Keefe, B. Michael, Mans, Douglas M., Kaelin, David E., Martin, Stephen F.

“…We report the first total synthesis of the complex C-aryl glycoside isokidamycin, the epimer of the naturally-occurring pluramycin antibiotic kidamycin. The…”
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Total Synthesis of Isokidamycin by O’Keefe, B. Michael, Mans, Douglas M, Kaelin, David E, Martin, Stephen F

“…The synthesis of isokidamycin, which represents the first total synthesis of a bis-C-aryl glycoside natural product in the pluramycin family, has been…”
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Highly Substituted Enantioenriched Cyclopentane Derivatives by Palladium-Catalyzed [3 + 2] Trimethylenemethane Cycloadditions with Disubstituted Nitroalkenes by Trost, Barry M, Bringley, Dustin A, O’Keefe, B. Michael

“…β,β-Disubstituted nitroalkenes readily undergo palladium-catalyzed [3 + 2] cycloaddition with trimethylenemethane to generate nitrocyclopentanes in excellent…”
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Synthesis of Lenacapavir Sodium: Active Pharmaceutical Ingredient Process Development and Scale-up by Wagner, Anna M., Bonderoff, Sara A., Chang, Stanley, Deignan, Jeffrey, Esanu, Michelle M., Van Huynh, Huy, Niu, Tianmin, Ngo, Vinh, O’Keefe, B. Michael, Phoenix, Jenny, Rainey, Trevor J., Roberts, Benjamin J., Shen, Jinyu, Stewart, Craig, Vandehey, Amanda L., Wolckenhauer, Scott A., Wong, Chloe Y., Yarmuch, Brian H.

“…Lenacapavir sodium (GS-6207-02) is a first-in-class HIV capsid inhibitor. Process development of the four-step final assembly of lenacapavir sodium from four…”
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Propargyl Alcohols as β-Oxocarbenoid Precursors for the Ruthenium-Catalyzed Cyclopropanation of Unactivated Olefins by Redox Isomerization by Trost, Barry M, Breder, Alexander, O’Keefe, B. Michael, Rao, Meera, Franz, Adam W

“…An atom-economical method for the direct synthesis of [3.1.0]- and [4.1.0]-bicyclic frameworks via Ru-catalyzed redox bicycloisomerization of enynols is…”
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Facile access to sterically hindered aryl ketones via carbonylative cross-coupling: application to the total synthesis of luteolin: Tetrahedron Young Investigator award 2011. Useful Synthetic Methods: Innovative Developments and Applications. F. Dean Toste by O'KEEFE, B. Michael, SIMMONS, Nicholas, MARTIN, Stephen F

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Baseline donor characteristics in the Cornea Donor Study by Sugar, Alan, Gal, Robin L, Beck, roy W, Ruedy, Katrina J, Blanton, Christopher L, Feder, Robert S, Hardten, David R, Holland, Edward J, Lass, Jonathan H, Mannis, Mark J, O'Keefe, Michael B

“…The Cornea Donor Study (CDS) is an ongoing study that is being conducted to determine whether donor age is related to long-term corneal graft survival…”
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Corneal collagen crosslinking in children with keratoconus by McAnena, Lisa, MB, BCh, O’Keefe, Michael, MB, BCh

“…Purpose To report the visual, refractive, and tomographic outcomes of corneal collagen crosslinking (CXL) in pediatric patients with keratoconus. Methods The…”
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