Search Results - "O'KEEFE, R. J"

Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis by Eliseev, R A, Dong, Y-F, Sampson, E, Zuscik, M J, Schwarz, E M, O'Keefe, R J, Rosier, R N, Drissi, M H

“…The Runx family of transcription factors regulate cell growth and differentiation, and control the expression of target genes involved in cell fate decisions…”
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Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells by ITO, H, GOATER, J. J, TIYAPATANAPUTI, P, RUBERY, P. T, O'KEEFE, R. J, SCHWARZ, E. M

“…Deficiencies in skeletal tissue repair and regeneration lead to conditions like osteoarthritis, osteoporosis and degenerative disc disease. While no cure for…”
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In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus vector by Ulrich-Vinther, M, Duch, M.R, Søballe, K, O’Keefe, R.J, Schwarz, E.M, Pedersen, F.S

“…Purposes. (1) To investigate the efficiency of direct in vivo adeno-associated virus (AAV) vector-mediated gene transduction to chondrocytes in relation to…”
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Effect of Anti‐Tumor Necrosis Factor-α Gene Therapy on Wear Debris‐Induced Osteolysis by Childs, Lisa M, Goater, J Jeffrey, OʼKeefe, Regis J, Schwarz, Edward M

“…BackgroundParticle phagocytosis by macrophages induces the secretion of tumor necrosis factor-α, which is involved in the development of an osteolytic…”
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Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis by Goater, J, Müller, R, Kollias, G, Firestein, G S, Sanz, I, O'Keefe, R J, Schwarz, E M

“…To evaluate the utility of the adeno associated viral (AAV) vector for gene delivery to joint cells in vivo and in vitro, and to assess its potential as a…”
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BMP‐6 Is an Autocrine Stimulator of Chondrocyte Differentiation by Grimsrud, Christopher D., Romano, Paul R., D'souza, Mary, Puzas, J. Edward, Reynolds, Paul R., Rosier, Randy N., O'keefe, Regis J.

“…While parathyroid hormone‐related protein (PTHrP) has been characterized as an important negative regulator of chondrocyte maturation in the growth plate, the…”
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RNA-seq analysis of chondrocyte transcriptome reveals genetic heterogeneity in LG/J and SM/J murine strains by Duan, X., Cai, L., Schmidt, E.J., Shen, J., Tycksen, E.D., O'Keefe, R.J., Cheverud, J.M., Rai, M.F.

“…To investigate the transcriptomic differences in chondrocytes obtained from LG/J (large, healer) and SM/J (small, non-healer) murine strains in an attempt to…”
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Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance by Liu, Z, Ren, Y, Mirando, A.J, Wang, C, Zuscik, M.J, O'Keefe, R.J, Hilton, M.J

“…Summary Objective Notch signaling has been identified as a critical regulator in cartilage development and joint maintenance, and loss of Notch signaling in…”
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Quantitative small-animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis by Schwarz, E M, Benz, E B, Lu, A P, Goater, J J, Mollano, A V, Rosier, R N, Puzas, J E, Okeefe, R J

“…Individuals who suffer from severe joint destruction caused by the various arthritidies often undergo total joint arthroplasty. A major limitation of this…”
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BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway by Li, T.-F, Yukata, K, Yin, G, Sheu, T, Maruyama, T, Jonason, J.H, Hsu, W, Zhang, X, Xiao, G, Konttinen, Y.T, Chen, D, O'Keefe, R.J

“…Summary Objective Bone morphogenic protein (BMP)-2 is approved for fracture non-union and spine fusion. We aimed to further dissect its downstream signaling…”
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Oral Pentoxifylline Inhibits Release of Tumor Necrosis Factor-Alpha from Human Peripheral Blood Monocytes : A Potential Treatment for Aseptic Loosening of Total Joint Components by Pollice, Paul F, Rosier, Randy N, Looney, R John, Puzas, J Edward, Schwarz, Edward M, O’Keefe, Regis J

“…BackgroundPentoxifylline (Trental) is a methylxanthine-derivative drug that has been used for more than twenty years in the treatment of peripheral vascular…”
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Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice by Zhu, M, Chen, M, Lichtler, A C, O'Keefe, R J, Chen, D

“…To determine the specificity and efficiency of the tamoxifen (TM)-induced Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic…”
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Role of surgical resection in pelvic Ewing's sarcoma by Scully, S P, Temple, H T, O'Keefe, R J, Scarborough, M T, Mankin, H J, Gebhardt, M C

“…The improved survival in patients with Ewing's sarcoma over the past two decades has placed increased importance on achievement of local disease control…”
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Increased Levels of Tumor Necrosis Factor-α and Interleukin-6 Protein and Messenger RNA in Human Peripheral Blood Monocytes due to Titanium Particles by BLAINE, THEODORE A, ROSIER, RANDY N, PUZAS, J EDWARD, LOONEY, R JOHN, REYNOLDS, PAUL R, REYNOLDS, SUSAN D, OʼKEEFE, REGIS J

“…Cytokines produced by macrophages in the periprosthetic membranes surrounding joint replacements have been implicated as causal agents in osteolysis and…”
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Targeted Deletion of Minpp1 Provides New Insight into the Activity of Multiple Inositol Polyphosphate Phosphatase In Vivo by Chi, Hongbo, Yang, Xiaonian, Kingsley, Paul D., O'Keefe, Regis J., Puzas, J. Edward, Rosier, Randy N., Shears, Stephen B., Reynolds, Paul R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Periosteal Progenitor Cell Fate in Segmental Cortical Bone Graft Transplantations: Implications for Functional Tissue Engineering by Zhang, Xinping, Xie, Chao, Lin, Angela SP, Ito, Hiromu, Awad, Hani, Lieberman, Jay R, Rubery, Paul T, Schwarz, Edward M, O'Keefe, Regis J, Guldberg, Robert E

“…A murine segmental femoral bone graft model was used to show the essential role of donor periosteal progenitor cells in bone graft healing. Transplantation of…”
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Mycobacterium bovis Osteomyelitis Involving a Hip Arthroplasty After Intravesicular Bacille Calmette-Guérin for Bladder Cancer by Guerra, Carmen E., Betts, Robert F., O'Keefe, Regis J., Shilling, Jack W.

“…Bacille Calmette-Guérin (BCG), an attenuated strain of Mycobacterium bovis, is one of the most effective agents in the treatment of superficial bladder cancer…”
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Functional outcome after soft-tissue reconstruction for limb salvage after sarcoma surgery by SERLETTI, J. M, CARRAS, A. J, O'KEEFE, R. J, ROSIER, R. N

“…Limb salvage has been achieved for patients with sarcoma by means of compartmental resection, soft-tissue reconstruction, and adjuvant therapy without…”
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Late recurrence of giant-cell tumor of bone. A report of four cases by Scully, S P, Mott, M P, Temple, H T, OʼKeefe, R J, OʼDonnell, R J, Mankin, H J

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Effects of transforming growth factor-beta 1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin-like growth factor-I by O'Keefe, R J, Crabb, I D, Puzas, J E, Rosier, R N

“…The local tissue metabolism is controlled through the complex interaction between systemic and local growth factors. In recent years, an increasing number of…”
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