Search Results - "O'KEEFE, JOHN"
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Do hippocampal pyramidal cells respond to nonspatial stimuli?
Published in Physiological reviews (01-07-2021)“…There are currently a number of theories of rodent hippocampal function. They fall into two major groups that differ in the role they impute to space in…”
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2
Hippocampal place cells have goal-oriented vector fields during navigation
Published in Nature (London) (28-07-2022)“…The hippocampal cognitive map supports navigation towards, or away from, salient locations in familiar environments 1 . Although much is known about how the…”
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3
Fully integrated silicon probes for high-density recording of neural activity
Published in Nature (London) (09-11-2017)“…New silicon probes known as Neuropixels are shown to record from hundreds of neurons simultaneously in awake and freely moving rodents. High-density neural…”
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4
Models of place and grid cell firing and theta rhythmicity
Published in Current opinion in neurobiology (01-10-2011)“…Graphical abstract Highlights ► Intracellular insights into theta phase precession and spiking in place cells. ► Verification of quantitative predictions from…”
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5
Local transformations of the hippocampal cognitive map
Published in Science (American Association for the Advancement of Science) (09-03-2018)“…Grid cells are neurons active in multiple fields arranged in a hexagonal lattice and are thought to represent the "universal metric for space." However, they…”
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Two Distinct Types of Eye-Head Coupling in Freely Moving Mice
Published in Current biology (08-06-2020)“…Animals actively interact with their environment to gather sensory information. There is conflicting evidence about how mice use vision to sample their…”
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7
Space in the brain: how the hippocampal formation supports spatial cognition
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (05-02-2014)“…Over the past four decades, research has revealed that cells in the hippocampal formation provide an exquisitely detailed representation of an animal's current…”
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A Head-Mounted Camera System Integrates Detailed Behavioral Monitoring with Multichannel Electrophysiology in Freely Moving Mice
Published in Neuron (Cambridge, Mass.) (10-10-2018)“…Breakthroughs in understanding the neural basis of natural behavior require neural recording and intervention to be paired with high-fidelity multimodal…”
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9
Grid cell symmetry is shaped by environmental geometry
Published in Nature (London) (12-02-2015)“…Neuronal grid cells fire in a spatial grid pattern laid out across the surface of a familiar environment, however the role of environmental boundaries in the…”
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10
Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings
Published in Science (American Association for the Advancement of Science) (16-04-2021)“…Measuring the dynamics of neural processing across time scales requires following the spiking of thousands of individual neurons over milliseconds and months…”
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11
Neural Representations of Location Composed of Spatially Periodic Bands
Published in Science (American Association for the Advancement of Science) (17-08-2012)“…The mammalian hippocampal formation provides neuronal representations of environmental location, but the underlying mechanisms are poorly understood. Here, we…”
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12
Representation of ethological events by basolateral amygdala neurons
Published in Cell reports (Cambridge) (07-06-2022)“…The accurate interpretation of ethologically relevant stimuli is crucial for survival. While basolateral amygdala (BLA) neuronal responses during fear…”
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13
Grid cell firing patterns signal environmental novelty by expansion
Published in Proceedings of the National Academy of Sciences - PNAS (23-10-2012)“…The hippocampal formation plays key roles in representing an animal’s location and in detecting environmental novelty to create or update those…”
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14
Reassessing Irish and Trans-Atlantic Immigration in the Age of Steam and Rail
Published in Journal of urban history (01-07-2021)Get full text
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15
Boundary Vector Cells in the Subiculum of the Hippocampal Formation
Published in The Journal of neuroscience (05-08-2009)“…"Boundary vector cells" were predicted to exist by computational models of the environmental inputs underlying the spatial firing patterns of hippocampal place…”
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16
Dual phase and rate coding in hippocampal place cells: Theoretical significance and relationship to entorhinal grid cells
Published in Hippocampus (2005)“…We review the ideas and data behind the hypothesis that hippocampal pyramidal cells encode information by their phase of firing relative to the theta rhythm of…”
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The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation
Published in Nature (London) (01-02-2018)“…A newly designed honeycomb maze presents several advantages over current spatial navigation assays that include greater control over the rat’s choices…”
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18
How vision and movement combine in the hippocampal place code
Published in Proceedings of the National Academy of Sciences - PNAS (02-01-2013)“…How do external environmental and internal movement-related information combine to tell us where we are? We examined the neural representation of environmental…”
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19
Development of the Hippocampal Cognitive Map in Preweanling Rats
Published in Science (American Association for the Advancement of Science) (18-06-2010)“…Orienting in large-scale space depends on the interaction of environmental experience and preconfigured, possibly innate, constructs. Place, head-direction,…”
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20
An oscillatory interference model of grid cell firing
Published in Hippocampus (01-01-2007)“…We expand upon our proposal that the oscillatory interference mechanism proposed for the phase precession effect in place cells underlies the grid‐like firing…”
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