Search Results - "O'KANE, Cecilia M"

Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management by Gorman, Ellen A, O'Kane, Cecilia M, McAuley, Daniel F

“…Acute respiratory distress syndrome (ARDS) is characterised by acute hypoxaemic respiratory failure with bilateral infiltrates on chest imaging, which is not…”
Get full text

Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer by Morrison, Thomas J, Jackson, Megan V, Cunningham, Erin K, Kissenpfennig, Adrien, McAuley, Daniel F, O'Kane, Cecilia M, Krasnodembskaya, Anna D

“…Acute respiratory distress syndrome (ARDS) remains a major cause of respiratory failure in critically ill patients. Mesenchymal stromal cells (MSCs) are a…”
Get full text

Mesenchymal Stromal Cells in Acute Respiratory Distress Syndrome: More Questions Than Answers by Millar, Jonathan E, O'Kane, Cecilia M

“…Millar and O'Kane discuss the study by Batchinsky et al which uses a porcine model of smoke inhalation injury to compare the therapeutic efficacy of autologous…”
Get full text

Understanding the Role of Mesenchymal Stromal Cells in Treating COVID-19 Acute Respiratory Distress Syndrome by O'Kane, Cecilia M, Matthay, Michael A

“…O'Kane and Matthay discuss the study by M. E. Bowdish and colleagues on bone marrow-derived mesenchymal stromal cells (MSCs) for the treatment of moderate to…”
Get full text

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS by Jackson, Megan V., Morrison, Thomas J., Doherty, Declan F., McAuley, Daniel F., Matthay, Michael A., Kissenpfennig, Adrien, O'Kane, Cecilia M., Krasnodembskaya, Anna D.

“…Mesenchymal stromal cells (MSC) have been reported to improve bacterial clearance in preclinical models of Acute Respiratory Distress Syndrome (ARDS) and…”
Get full text

Cell-based Therapies for Acute Respiratory Distress Syndrome: Where Are We Now? by Curley, Gerard F, O'Kane, Cecilia M, McAuley, Daniel F, Matthay, Michael A, Laffey, John G

“…There is considerable interest in the potential for cell-based therapies, particularly mesenchymal stromal cells (MSCs) and their products, as a therapy for…”
Get full text

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury by Proudfoot, Alastair, Bayliffe, Andrew, O'Kane, Cecilia M, Wright, Tracey, Serone, Adrian, Bareille, Philippe Jean, Brown, Vanessa, Hamid, Umar I, Chen, Younan, Wilson, Robert, Cordy, Joanna, Morley, Peter, de Wildt, Ruud, Elborn, Stuart, Hind, Matthew, Chilvers, Edwin R, Griffiths, Mark, Summers, Charlotte, McAuley, Daniel Francis

“…Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its…”
Get more information

Simvastatin in the Acute Respiratory Distress Syndrome by McAuley, Daniel F, Laffey, John G, O'Kane, Cecilia M, Perkins, Gavin D, Mullan, Brian, Trinder, T. John, Johnston, Paul, Hopkins, Philip A, Johnston, Andrew J, McDowell, Cliona, McNally, Christine

“…In this study, patients with acute respiratory distress syndrome who were not receiving statins were assigned to receive simvastatin or placebo. At 28 days,…”
Get full text

Baseline plasma IL-18 may predict simvastatin treatment response in patients with ARDS: a secondary analysis of the HARP-2 randomised clinical trial by Boyle, Andrew James, Ferris, Peter, Bradbury, Ian, Conlon, John, Shankar-Hari, Manu, Rogers, Angela J, O'Kane, Cecilia M, McAuley, Daniel F

“…Interleukin (IL)-18 is a marker of inflammasome activation, and high baseline plasma IL-18 is associated with increased mortality in patients with…”
Get full text

Where next for cell-based therapy in ARDS by Boyle, Andrew James, O'Kane, Cecilia M, McAuley, Daniel Francis

Get more information

Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials by Pienkos, Shaun M, Moore, Andrew R, Guan, Jiazhen, Levitt, Joseph E, Matthay, Michael A, Baron, Rebecca M, Conlon, John, McAuley, Daniel F, O'Kane, Cecilia M, Rogers, Angela J

“…Two acute respiratory distress syndrome (ARDS) trials showed no benefit for statin therapy, though secondary analyses suggest inflammatory subphenotypes may…”
Get full text

Innate Lymphoid Cells Are the Predominant Source of IL-17A during the Early Pathogenesis of Acute Respiratory Distress Syndrome by Muir, Roshell, Osbourn, Megan, Dubois, Alice V, Doran, Emma, Small, Donna M, Monahan, Avril, O'Kane, Cecilia M, McAllister, Katherine, Fitzgerald, Denise C, Kissenpfennig, Adrien, McAuley, Daniel F, Ingram, Rebecca J

“…IL-17A is purported to help drive early pathogenesis in acute respiratory distress syndrome (ARDS) by enhancing neutrophil recruitment. Although IL-17A is the…”
Get full text

Emerging drugs for treating the acute respiratory distress syndrome by Shaw, Timothy D, McAuley, Daniel F, O'Kane, Cecilia M

“…The acute respiratory distress syndrome (ARDS) is a common and catastrophic condition, with a high mortality rate and economic burden on society. Despite…”
Get more information

Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis by Boyle, Andrew J, Di Gangi, Stefania, Hamid, Umar I, Mottram, Linda-Jayne, McNamee, Lia, White, Griania, Cross, L J Mark, McNamee, James J, O'Kane, Cecilia M, McAuley, Daniel F

“…Acute respiratory distress syndrome (ARDS) is a common clinical syndrome with high mortality and long-term morbidity. To date there is no effective…”
Get full text

Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation by Spence, Shaun, Greene, Michelle K, Fay, François, Hams, Emily, Saunders, Sean P, Hamid, Umar, Fitzgerald, Marianne, Beck, Jonathan, Bains, Baljinder K, Smyth, Peter, Themistou, Efrosyni, Small, Donna M, Schmid, Daniela, O'Kane, Cecilia M, Fitzgerald, Denise C, Abdelghany, Sharif M, Johnston, James A, Fallon, Padraic G, Burrows, James F, McAuley, Daniel F, Kissenpfennig, Adrien, Scott, Christopher J

“…Sepsis is the most frequent cause of death in hospitalized patients, and severe sepsis is a leading contributory factor to acute respiratory distress syndrome…”
Get more information

Human mesenchymal stromal cells inhibit Mycobacterium avium replication in clinically relevant models of lung infection by Shaw, Timothy D, Krasnodembskaya, Anna D, Schroeder, Gunnar N, Doherty, Declan F, Silva, Johnatas Dutra, Tandel, Shikha M, Su, Yue, Butler, David, Ingram, Rebecca J, O'Kane, Cecilia M

“…Novel therapeutic strategies are urgently needed for complex pulmonary disease (MAC-PD). Human mesenchymal stromal cells (MSCs) can directly inhibit MAC…”
Get more information

TRPV2 modulates mechanically Induced ATP Release from Human bronchial epithelial cells by Dunne, Orla M, Martin, S Lorraine, Sergeant, Gerard P, McAuley, Daniel F, O'Kane, Cecilia M, Button, Brian, McGarvey, Lorcan P, Lundy, Fionnuala T

“…Repetitive bouts of coughing expose the large airways to significant cycles of shear stress. This leads to the release of alarmins and the tussive agent…”
Get full text

Keratinocyte Growth Factor Promotes Epithelial Survival and Resolution in a Human Model of Lung Injury by SHYAMSUNDAR, Murali, MCAULEY, Daniel F, MATTHAY, Michael A, O'KANE, Cecilia M, INGRAM, Rebecca J, GIBSON, David S, O'KANE, Donal, MCKEOWN, Scott T, EDWARDS, Alex, TAGGART, Cliff, ELBORN, Joseph S, CALFEE, Carolyn S

“…Increasing epithelial repair and regeneration may hasten resolution of lung injury in patients with the acute respiratory distress syndrome (ARDS). In animal…”
Get full text

Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome by McKelvey, Michael C, Abladey, Anthony A, Small, Donna M, Doherty, Declan F, Williams, Richard, Scott, Aaron, Spek, C Arnold, Borensztajn, Keren S, Holsinger, Leslie, Booth, Robert, O'Kane, Cecilia M, McAuley, Daniel F, Taggart, Clifford C, Weldon, Sinéad

“…Although the cysteine protease cathepsin S has been implicated in the pathogenesis of several inflammatory lung diseases, its role has not been examined in the…”
Get full text

Elevated Plasma Interleukin-18 Identifies High-Risk Acute Respiratory Distress Syndrome Patients not Distinguished by Prior Latent Class Analyses Using Traditional Inflammatory Cytokines: A Retrospective Analysis of Two Randomized Clinical Trials by Moore, Andrew R, Pienkos, Shaun M, Sinha, Pratik, Guan, Jiazhen, O'Kane, Cecilia M, Levitt, Joseph E, Wilson, Jennifer G, Shankar-Hari, Manu, Matthay, Michael A, Calfee, Carolyn S, Baron, Rebecca M, McAuley, Daniel F, Rogers, Angela J

“…Interleukin-18 (IL-18) plasma level and latent class analysis (LCA) have separately been shown to predict prognosis and treatment response in acute respiratory…”
Get full text