Search Results - "O'Hara, Laura"

Androgen receptor roles in spermatogenesis and infertility by O'Hara, Laura, Ph.D, Smith, Lee B., Ph.D

“…Androgens such as testosterone are steroid hormones essential for normal male reproductive development and function. Mutations of androgen receptors (AR) are…”
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Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells by Kilcoyne, Karen R, Smith, Lee B, Atanassova, Nina, Macpherson, Sheila, McKinnell, Chris, van den Driesche, Sander, Jobling, Matthew S, Chambers, Thomas J G, De Gendt, Karel, Verhoeven, Guido, O'Hara, Laura, Platts, Sophie, Renato de Franca, Luiz, Lara, Nathália L M, Anderson, Richard A, Sharpe, Richard M

“…Fetal growth plays a role in programming of adult cardiometabolic disorders, which in men, are associated with lowered testosterone levels. Fetal growth and…”
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Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late‐onset Leydig cell apoptosis in both mice and men by O'Hara, Laura, McInnes, Kerry, Simitsidellis, Ioannis, Morgan, Stephanie, Atanassova, Nina, Slowikowska‐Hilczer, Jolanta, Kula, Krzysztof, Szarras‐Czapnik, Maria, Milne, Laura, Mitchell, Rod T., Smith, Lee B.

“…Leydig cell number and function decline as men age, and low testosterone is associated with all “Western” cardio‐metabolic disorders. However, whether…”
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Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing by Gannon, Anne-Louise, O’Hara, Laura, Mason, J. Ian, Jørgensen, Anne, Frederiksen, Hanne, Milne, Laura, Smith, Sarah, Mitchell, Rod T., Smith, Lee B.

“…Androgens are known to be an essential regulator of male health. Androgen receptor (AR) is widely expressed throughout the adrenal cortex, yet the wider role…”
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Pituitary androgen receptor signalling regulates prolactin but not gonadotrophins in the male mouse by O'Hara, Laura, Curley, Michael, Tedim Ferreira, Maria, Cruickshanks, Lyndsey, Milne, Laura, Smith, Lee B

“…Production of the androgen testosterone is controlled by a negative feedback loop within the hypothalamic-pituitary-gonadal (HPG) axis. Stimulation of…”
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Testosterone regulation on quiescin sulfhydryl oxidase 2 synthesis in the epididymis by Wang, Tse-En, Minabe, Shiori, Matsuda, Fuko, Li, Sheng-Hsiang, Tsukamura, Hiroko, Maeda, Kei-Ichiro, Smith, Lee, O’Hara, Laura, Gadella, Bart M, Tsai, Pei-Shiue

“…The epididymis is an androgen-responsive organ, whose structure and functions are modulated by the coordination between androgen and epididymal cues. Highly…”
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Control of Phospholipid Synthesis by Phosphorylation of the Yeast Lipin Pah1p/Smp2p Mg2+-dependent Phosphatidate Phosphatase by O'Hara, Laura, Han, Gil-Soo, Peak-Chew, Sew, Grimsey, Neil, Carman, George M., Siniossoglou, Symeon

“…Phosphorylation of the conserved lipin Pah1p/Smp2p in Saccharomyces cerevisiae was previously shown to control transcription of phospholipid biosynthetic genes…”
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Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders by Gannon, Anne-Louise, O’Hara, Laura, Mason, J. Ian, Rebourcet, Diane, Smith, Sarah, Traveres, Adriana, Alcaide-Corral, Carlos Jose, Frederiksen, Hanne, Jørgensen, Anne, Milne, Laura, Mitchell, Rod T., Smith, Lee B.

“…The hypothalamic-pituitary-adrenal (HPA) axis regulates responses to internal and external stressors. Many patients diagnosed with conditions such as…”
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An Unconventional Diacylglycerol Kinase That Regulates Phospholipid Synthesis and Nuclear Membrane Growth by Han, Gil-Soo, O'Hara, Laura, Carman, George M., Siniossoglou, Symeon

“…Changes in nuclear size and shape during the cell cycle or during development require coordinated nuclear membrane remodeling, but the underlying molecular…”
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Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis by Rebourcet, Diane, O'Shaughnessy, Peter J, Pitetti, Jean-Luc, Monteiro, Ana, O'Hara, Laura, Milne, Laura, Tsai, Yi Ting, Cruickshanks, Lyndsey, Riethmacher, Dieter, Guillou, Florian, Mitchell, Rod T, van't Hof, Rob, Freeman, Tom C, Nef, Serge, Smith, Lee B

“…Sertoli cells (SCs) regulate testicular fate in the differentiating gonad and are the main regulators of spermatogenesis in the adult testis; however, their…”
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Development and Characterization of Cell-Specific Androgen Receptor Knockout Mice by O'Hara, Laura, Smith, Lee B

“…Conditional gene targeting has revolutionized molecular genetic analysis of nuclear receptor proteins, however development and analysis of such conditional…”
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Modelling the Structure and Dynamics of Biological Pathways by O'Hara, Laura, Livigni, Alessandra, Theo, Thanos, Boyer, Benjamin, Angus, Tim, Wright, Derek, Chen, Sz-Hau, Raza, Sobia, Barnett, Mark W, Digard, Paul, Smith, Lee B, Freeman, Tom C

“…There is a need for formalised diagrams that both summarise current biological pathway knowledge and support modelling approaches that explain and predict…”
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Hyperprolactinemia in a male pituitary androgen receptor knockout mouse is associated with female‐like lactotroph development by O’Hara, Laura, Christian, Helen C., Le Tissier, Paul, Smith, Lee B.

“…Background Circulating prolactin concentration in rodents and humans is sexually dimorphic. Oestrogens are a well‐characterised stimulator of prolactin…”
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Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity by Gannon, Anne-Louise, O'Hara, Laura, Mason, Ian J, Jørgensen, Anne, Frederiksen, Hanne, Curley, Michael, Milne, Laura, Smith, Sarah, Mitchell, Rod T, Smith, Lee B

“…Adrenal androgens are fundamental mediators of ovarian folliculogenesis, embryonic implantation, and breast development. Although adrenal androgen function in…”
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Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse testis by O'Shaughnessy, Peter J, Mitchell, Rod T, Monteiro, Ana, O'Hara, Laura, Cruickshanks, Lyndsey, der Grinten, Hedi Claahsen-van, Brown, Pamela, Abel, Margaret, Smith, Lee B

“…The interstitium of the mouse testis contains Leydig cells and a small number of steroidogenic cells with adrenal characteristics which may be derived from the…”
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Discourses of Diabetes Management in Patient-Physician Interactions by O'Hara, Laura L, Shue, Carolyn K

“…Discussions of diabetes management are challenging for patients and physicians during treatment plan appointments—in large part because “diabetes management”…”
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Androgen Receptor Expression in the Caput Epididymal Epithelium Is Essential for Development of the Initial Segment and Epididymal Spermatozoa Transit by O'Hara, Laura, Welsh, Michelle, Saunders, Philippa T.K, Smith, Lee B

“…Ablation of androgen receptor in caput epididymal epithelium impairs normal epithelial differentiation and causes obstructive azoospermia. The epididymis plays…”
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Targeting of GFP-Cre to the mouse Cyp11a1 locus both drives cre recombinase expression in steroidogenic cells and permits generation of Cyp11a1 knock out mice by O'Hara, Laura, York, Jean Philippe, Zhang, Pumin, Smith, Lee B

“…To permit conditional gene targeting of floxed alleles in steroidogenic cell-types we have generated a transgenic mouse line that expresses Cre Recombinase…”
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Temporal and Spatial Regulation of the Phosphatidate Phosphatases Lipin 1 and 2 by Grimsey, Neil, Han, Gil-Soo, O'Hara, Laura, Rochford, Justin J., Carman, George M., Siniossoglou, Symeon

“…Lipins are the founding members of a novel family of Mg2+-dependent phosphatidate phosphatases (PAP1 enzymes) that play key roles in fat metabolism and lipid…”
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Characterization of the Yeast DGK1-encoded CTP-dependent Diacylglycerol Kinase by Han, Gil-Soo, O'Hara, Laura, Siniossoglou, Symeon, Carman, George M.

“…The Saccharomyces cerevisiae DGK1 gene encodes a diacylglycerol kinase enzyme that catalyzes the formation of phosphatidate from diacylglycerol. Unlike the…”
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