Search Results - "O'Hara, Connor"

Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity by Morla, Shravan, Ravikumar, Ongolu, O’Hara, Connor, Boothello, Rio, Vera, Alberto, Abdelfadiel, Elsamani I., Fayyad, Rawan, Afosah, Daniel K., Sharon, Chetna, Fernandez, Leopoldo, Shah, Syed Ammer, Patel, Bhaumik B., Desai, Umesh R.

“…Sulfated glycosaminoglycans (GAGs), or synthetic mimetics thereof, are not favorably viewed as orally bioavailable drugs owing to their high number of anionic…”
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Glycan Modulation of Insulin‐like Growth Factor‐1 Receptor by Boothello, Rio S., Sankaranarayanan, Nehru Viji, Sistla, Jyothi C., Nagarajan, Balaji, Sharon, Chetna, Chittum, John E., Niyaz, Rabiya Y., Roy, Swarnali, Nandi, Aditi, O'Hara, Connor P., Gangji, Rahaman Navaz, Afosah, Daniel K., Ongolu, Ravikumar, Patel, Bhaumik B., Desai, Umesh R.

“…The insulin‐like growth factor‐1 receptor (IGF‐1R) is a receptor tyrosine kinase (RTK) that plays critical roles in cancer. Microarray, computational,…”
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Glycan Modulation of Insulin‐like Growth Factor‐1 Receptor by Boothello, Rio S., Sankaranarayanan, Nehru Viji, Sistla, Jyothi C., Nagarajan, Balaji, Sharon, Chetna, Chittum, John E., Niyaz, Rabiya Y., Roy, Swarnali, Nandi, Aditi, O'Hara, Connor P., Gangji, Rahaman Navaz, Afosah, Daniel K., Ongolu, Ravikumar, Patel, Bhaumik B., Desai, Umesh R.

“…The insulin‐like growth factor‐1 receptor (IGF‐1R) is a receptor tyrosine kinase (RTK) that plays critical roles in cancer. Microarray, computational,…”
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On the Selectivity of Heparan Sulfate Recognition by SARS-CoV‑2 Spike Glycoprotein by Chittum, John E, Sankaranarayanan, Nehru Viji, O’Hara, Connor P, Desai, Umesh R

“…SARS-CoV-2 infects human cells through its surface spike glycoprotein (SgP), which relies on host cell surface heparan sulfate (HS) proteoglycans that…”
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Heparan Sulfate Microarray Lends Insight into Selective Binding of SARS‐CoV‐2 Spike Glycoprotein by Chittum, John, Sankaranarayanan, Nehru, O'Hara, Connor, Desai, Umesh

“…SARS‐CoV‐2 remains a prominent threat to human lives despite the recent approval of vaccines and antibodies across the world. There is also a growing concern…”
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Abstract 1166: Structurally defined glycosaminoglycan mimetics exhibit preference for proteins of the growth factor family by O'Hara, Connor P., Sankaranarayanan, Nehru V., Boothello, Rio S., Patel, Bhaumik B., Desai, Umesh R.

“…Heparan sulfate (HS), a glycosaminoglycans of considerable structural diversity, has been implicated in a wide-variety of complex roles including regulation of…”
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Selective Inhibition of a Panel of Cancer Stem Cell Lines by Novel Glycosaminoglycan Mimetics by O'Hara, Connor Patrick, Morla, Shravan, Afosah, Daniel, Sharon, Chetna, Boothello, Rio, Patel, Bhaumik, Desai, Umesh

“…Purpose To characterize the anti‐cancer stem cell (CSC) properties of non‐saccharide glycosaminoglycan mimetics (NSGMs) and their lipid‐modified analogs in a…”
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Abstract 6353: Cholesterol modification enhances potency and pharmacokinetic properties of a selective cancer stem cell targeting agent by O'Hara, Connor P., Boothello, Rio S., Morla, Shravan, Vera, Alberto, Afosah, Daniel K., Sankaranarayanan, Nehru V., Nagarajan, Balaji, Sharon, Chetna, Patel, Bhaumik B., Desai, Umesh R.

“…Increasing evidence supports the concept that tumor-initiating cancer stem cells (CSCs) are responsible for the relapse and reconstitution of formerly treated…”
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Lipophilic Modification of an Anti‐Cancer Stem Cell Agent Improves Pharmacokinetic and Anti‐Cancer Properties by Morla, Shravan, Afosah, Daniel K., O'Hara, Connor, Boothello, Rio, Patel, Bhaumik B., Sakagami, Masahiro, Desai, Umesh R.

“…Current anti‐cancer agents target bulk tumor cells but do not eradicate the rare, quiescent, cancer stem cells (CSCs). CSCs are being increasingly recognized…”
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Abstract 2653: Synthetic, small molecule glycosaminoglycan mimetics induce novel anti-cancer activity through preferential targeting of a growth factor receptor by O'Hara, Connor, Morla, Shravan, Ongolu, Ravikumar, Patel, Nirmita, Boothello, Rio, Patel, Bhaumik, Desai, Umesh

“…Glycosaminoglycans (GAGs), such as heparan sulfate (HS), have been implicated in tumor initiation, progression and metastasis. Earlier we have shown that a…”
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Abstract 2334: Non-Saccharide Glycosaminoglycan Mimetics Selectively Target Certain Receptor Tyrosine Kinases to Induce Anti-Cancer Stem Cell Activity by O’Hara, Connor, Morla, Shravan, Ongolu, Ravi Kumar, Sankaranarayanan, Nehru Viji, Patel, Nirmita, Boothello, Rio, Patel, Bhaumik, Desai, Umesh

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Arbitration, the law market, and the law of lawyering by O’Connor, Erin O’Hara, Rutledge, Peter B.

“…•Arbitration caseloads are positively correlated with a state's UPL rules.•Most other legal changes lack a statistically significant correlation with…”
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