Search Results - "O'Halloran, Thomas V."

Christopher T. Walsh (1944-2023) by O'Halloran, Thomas V

“…A luminous scholar and mentor at the interface of chemistry, biology, and medicine…”
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Arsenoplatin‑1 Is a Dual Pharmacophore Anticancer Agent by Miodragović, Đenana, Merlino, Antonello, Swindell, Elden P, Bogachkov, Abraham, Ahn, Richard W, Abuhadba, Sara, Ferraro, Giarita, Marzo, Tiziano, Mazar, Andrew P, Messori, Luigi, O’Halloran, Thomas V

“…Arsenoplatins are adducts of two chemically important anticancer drugs, cisplatin and arsenic trioxide, that have a Pt­(II) bond to an As­(III) hydroxide…”
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Allosteric transcriptional regulation via changes in the overall topology of the core promoter by Philips, Steven J., Canalizo-Hernandez, Monica, Yildirim, Ilyas, Schatz, George C., Mondragón, Alfonso, O'Halloran, Thomas V.

“…Many transcriptional activators act at a distance from core promoter elements and work by recruiting RNA polymerase through protein-protein interactions. We…”
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CueR activates transcription through a DNA distortion mechanism by Fang, Chengli, Philips, Steven J., Wu, Xiaoxian, Chen, Kui, Shi, Jing, Shen, Liqiang, Xu, Juncao, Feng, Yu, O’Halloran, Thomas V., Zhang, Yu

“…The MerR-family transcription factors (TFs) are a large group of bacterial proteins responding to cellular metal ions and multiple antibiotics by binding…”
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Dynamic zinc fluxes regulate meiotic progression in Caenorhabditis elegans by Mendoza, Adelita D., Sue, Aaron, Antipova, Olga, Vogt, Stefan, Woodruff, Teresa K., Wignall, Sarah M., O'Halloran, Thomas V.

“…Zinc influx and efflux events are essential for meiotic progression in oocytes of several mammalian and amphibian species, but it is less clear whether this…”
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Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks by Que, Emily L., Bleher, Reiner, Duncan, Francesca E., Kong, Betty Y., Gleber, Sophie C., Vogt, Stefan, Chen, Si, Garwin, Seth A., Bayer, Amanda R., Dravid, Vinayak P., Woodruff, Teresa K., O'Halloran, Thomas V.

“…Fertilization of a mammalian egg initiates a series of ‘zinc sparks’ that are necessary to induce the egg-to-embryo transition. Despite the importance of these…”
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Molecular Pathways: Revisiting Glycogen Synthase Kinase-3β as a Target for the Treatment of Cancer by Walz, Amy, Ugolkov, Andrey, Chandra, Sunandana, Kozikowski, Alan, Carneiro, Benedito A, O'Halloran, Thomas V, Giles, Francis J, Billadeau, Daniel D, Mazar, Andrew P

“…Glycogen synthase kinase-3β (GSK-3β), a serine/threonine protein kinase, is a complex regulator of numerous cellular functions. GSK-3β is a unique kinase which…”
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Activation of superoxide dismutases: Putting the metal to the pedal by Culotta, Valeria Cizewski, Yang, Mei, O'Halloran, Thomas V.

“…Superoxide dismutases (SOD) are important anti-oxidant enzymes that guard against superoxide toxicity. Various SOD enzymes have been characterized that employ…”
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A new role for Zinc limitation in bacterial pathogenicity: modulation of α-hemolysin from uropathogenic Escherichia coli by Velasco, Elsa, Wang, Suning, Sanet, Marianna, Fernández-Vázquez, Jorge, Jové, Daniel, Glaría, Estibaliz, Valledor, Annabel F., O’Halloran, Thomas V., Balsalobre, Carlos

“…Metal limitation is a common situation during infection and can have profound effects on the pathogen’s success. In this report, we examine the role of zinc…”
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The zinc spark is an inorganic signature of human egg activation by Duncan, Francesca E., Que, Emily L., Zhang, Nan, Feinberg, Eve C., O’Halloran, Thomas V., Woodruff, Teresa K.

“…Egg activation refers to events required for transition of a gamete into an embryo, including establishment of the polyspermy block, completion of meiosis,…”
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A place for thioether chemistry in cellular copper ion recognition and trafficking by Davis, Anna V, O'Halloran, Thomas V

“…Over the last decade, cysteine thiolate ligands have been shown to be critical to the Cu( I ) (cuprous) binding chemistry of many cytosolic metallochaperone…”
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The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription by Fang, Chengli, Li, Linyu, Zhao, Yihan, Wu, Xiaoxian, Philips, Steven J., You, Linlin, Zhong, Mingkang, Shi, Xiaojin, O’Halloran, Thomas V., Li, Qunyi, Zhang, Yu

“…The MerR-family proteins represent a unique family of bacteria transcription factors (TFs), which activate transcription in a manner distinct from canonical…”
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Quantitative imaging approaches to understanding biological processing of metal ions by Zee, David Z., MacRenaris, Keith W., O'Halloran, Thomas V.

“…Faster, more sensitive, and higher resolution quantitative instrumentation are aiding a deeper understanding of how inorganic chemistry regulates key…”
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Iron drives anabolic metabolism through active histone demethylation and mTORC1 by Shapiro, Jason S., Chang, Hsiang-Chun, Tatekoshi, Yuki, Zhao, Zibo, Waxali, Zohra Sattar, Hong, Bong Jin, Chen, Haimei, Geier, Justin A., Bartom, Elizabeth T., De Jesus, Adam, Nejad, Farnaz K., Mahmoodzadeh, Amir, Sato, Tatsuya, Ramos-Alonso, Lucia, Romero, Antonia Maria, Martinez-Pastor, Maria Teresa, Jiang, Shang-Chuan, Sah-Teli, Shiv K., Li, Liming, Bentrem, David, Lopaschuk, Gary, Ben-Sahra, Issam, O’Halloran, Thomas V., Shilatifard, Ali, Puig, Sergi, Bergelson, Joy, Koivunen, Peppi, Ardehali, Hossein

“…All eukaryotic cells require a minimal iron threshold to sustain anabolic metabolism. However, the mechanisms by which cells sense iron to regulate anabolic…”
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Zinc availability regulates exit from meiosis in maturing mammalian oocytes by O'Halloran, Thomas V, Woodruff, Teresa K, Kim, Alison M, Vogt, Stefan

“…Probing the biological location and function of transition metals has proven difficult. X-ray fluorescence microscopy in combination with an array of metal…”
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Interrogating Intracellular Zinc Chemistry with a Long Stokes Shift Zinc Probe ZincBY‑4 by Garwin, Seth A, Kelley, Matthew S, Sue, Aaron C, Que, Emily L, Schatz, George C, Woodruff, Teresa K, O’Halloran, Thomas V

“…Previous work has shown that fluctuations in zinc content and subcellular localization play key roles in regulating cell cycle progression; however, a deep…”
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Structural and mechanistic basis of zinc regulation across the E. coli Zur regulon by Gilston, Benjamin A, Wang, Suning, Marcus, Mason D, Canalizo-Hernández, Mónica A, Swindell, Elden P, Xue, Yi, Mondragón, Alfonso, O'Halloran, Thomas V

“…Commensal microbes, whether they are beneficial or pathogenic, are sensitive to host processes that starve or swamp the prokaryote with large fluctuations in…”
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Zinc Sparks Are Triggered by Fertilization and Facilitate Cell Cycle Resumption in Mammalian Eggs by Kim, Alison M, Bernhardt, Miranda L, Kong, Betty Y, Ahn, Richard W, Vogt, Stefan, Woodruff, Teresa K, O’Halloran, Thomas V

“…In last few hours of maturation, the mouse oocyte takes up over twenty billion zinc atoms and arrests after the first meiotic division, until fertilization or…”
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Folate-mediated intracellular drug delivery increases the anticancer efficacy of nanoparticulate formulation of arsenic trioxide by Chen, Haimei, Ahn, Richard, Van den Bossche, Jeroen, Thompson, David H., O'Halloran, Thomas V.

“…Arsenic trioxide (As 2 O 3 ) is a frontline drug for treatment of acute promyelocytic leukemia and is in clinical trials for treatment of other malignancies,…”
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Anticancer Activity of Small-Molecule and Nanoparticulate Arsenic(III) Complexes by Swindell, Elden P., Hankins, Patrick L., Chen, Haimei, Miodragović, Đenana U., O’Halloran, Thomas V.

“…Starting in ancient China and Greece, arsenic-containing compounds have been used in the treatment of disease for over 3000 years. They were used for a variety…”
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