Search Results - "O'Gara, Margaret"

Universal Catalytic Domain Structure of AdoMet-dependent Methyltransferases by Schluckebier, Gerd, O'Gara, Margaret, Saenger, Wolfram, Cheng, Xiaodong

“…The DNA methyltransferases, M.HhaI and M.TaqI, and catecholO-methyl-transferase (COMT) catalyze the transfer of a methyl group from the…”
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Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors by Dublanchet, Anne-Claude, Ducrot, Pierre, Andrianjara, Charles, O’Gara, Margaret, Morales, Renaud, Compère, Delphine, Denis, Alexis, Blais, Stéphane, Cluzeau, Philippe, Courté, Karine, Hamon, Jacques, Moreau, François, Prunet, Marie-Laure, Tertre, Anita

“…A new class of MMP-12 inhibitors was discovered and optimized using structure-based drug design methods. Optimization resulted in the discovery of a compound…”
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A Structural Basis for the Preferential Binding of Hemimethylated DNA byHhaI DNA Methyltransferase by O'Gara, Margaret, Roberts, Richard J., Cheng, Xiaodong

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SEEING IN A NEW LIGHT: FROM REMEMBERING TO REFORMING IN ECUMENICAL DIALOGUE : Conversion and Reform in View of the Unity of the Church by O'GARA, Margaret

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Toward the Day When we Will Keep the Feast Together by O'Gara, Margaret

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Selective Urokinase-Type Plasminogen Activator Inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines by Fish, Paul V, Barber, Christopher G, Brown, David G, Butt, Richard, Collis, Michael G, Dickinson, Roger P, Henry, Brian T, Horne, Valerie A, Huggins, John P, King, Elizabeth, O'Gara, Margaret, McCleverty, Dawn, McIntosh, Fraser, Phillips, Christopher, Webster, Robert

“…1-Isoquinolinylguanidines were previously disclosed as potent and selective inhibitors of urokinase-type plasminogen activator (uPA). Further investigation of…”
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Crystal Structures of Novel Non-peptidic, Non-zinc Chelating Inhibitors Bound to MMP-12 by Morales, Renaud, Perrier, Sophie, Florent, Jean-Michel, Beltra, Joel, Dufour, Sylvie, De Mendez, Isabelle, Manceau, Peggy, Tertre, Anita, Moreau, François, Compere, Delphine, Dublanchet, Anne-Claude, O'Gara, Margaret

“…Human macrophage elastase (MMP-12) plays an important role in inflammatory processes and has been implicated in diseases such as emphysema and chronic…”
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Structure of PvuII DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignment by Gong, Weimin, O'Gara, Margaret, Blumenthal, Robert M., Cheng, Xiaodong

“…We have determined the structure of PvuII methyltransferase (M.PvuII) complexed with S-adenosyl-l-methionine (AdoMet) by multiwavelength anomalous diffraction,…”
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Three successive steps toward understanding papal primacy in Vatican I: Collegiality in the church II: theology and canon law by O'GARA, Margaret

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Enzymatic C5-Cytosine Methylation of DNA: Mechanistic Implications of New Crystal Structures for HhaI Methyltransferase-DNA-AdoHcy Complexes by O'Gara, Margaret, Klimaŝauskas, Saulius, Roberts, Richard J., Cheng, Xiaodong

“…The refined crystal structures of HhaI methyltransferase complexed with cognate unmethylated or methylated DNA together with S-adenosyl- L-homocysteine, along…”
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Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide by O'Gara, M, Zhang, X, Roberts, R J, Cheng, X

“…We have determined a structure for a complex formed between HhaI methyltransferase (M.HhaI) and S-adenosyl-L-methionine (AdoMet) in the presence of a…”
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A structural basis for the preferential binding of hemimethylated DNA by HhaI DNA methyltransferase by O'Gara, M, Roberts, R J, Cheng, X

“…The crystal structure of HhaI methyltransferase complexed with non-palindromic duplex DNA, containing a hemimethylated recognition sequence, and with the…”
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Counter-evidence of infallibility's exercise by O'GARA, Margaret

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Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine by Sheikhnejad, G, Brank, A, Christman, J K, Goddard, A, Alvarez, E, Ford, Jr, H, Marquez, V E, Marasco, C J, Sufrin, J R, O'gara, M, Cheng, X

“…A key step in the predicted mechanism of enzymatic transfer of methyl groups from S-adenosyl-l-methionine (AdoMet) to cytosine residues in DNA is the transient…”
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“Seeing in A New Light”: From Remembering to Reforming in Ecumenical Dialogue by O’Gara, Margaret

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Corrigendum to “Crystal Structures of Novel Non-peptidic, Non-zinc Chelating Inhibitors Bound to MMP-12” [J. Mol. Biol. (2004) 341, 1063–1076] by Morales, Renaud, Perrier, Sophie, Florent, Jean-Michel, Beltra, Joel, Dufour, Sylvie, De Mendez, Isabelle, Manceau, Peggy, Tertre, Anita, Moreau, François, Compere, Delphine, Dublanchet, Anne-Claude, O'Gara, Margaret

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Transition-metal Schiff-base complexes as ligands in tin chemistry. Part 7. Reactions of organotin(IV) Lewis acids with [M(L)] 2 [M=Ni, Cu and Zn; H 2L= N,N′-bis(3-methoxysalicylidene)benzene-1,3-diamine and its -1,4-diamine analog] by Clarke, Brenda, Clarke, Nuala, Cunningham, Desmond, Higgins, Tim, McArdle, Patrick, Nı́ Cholchúin, Máire, O'Gara, Margaret

“…Dinuclear complexes [M(3MeO-sal- m-phen)(H 2O)] 2 [M=Cu, Ni and Zn; 3MeO–H 2sal- m-phen= N,N′-bis(3-methoxysalicylidene)benzene-1,3-diamine] and [M(3MeO-sal-…”
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Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors: G-protein-coupled receptors in drug discovery by DUBLANCHET, Anne-Claude, DUCROT, Pierre, HAMON, Jacques, MOREAU, Francois, PRUNET, Marie-Laure, TERTRE, Anita, ANDRIANJARA, Charles, O'GARA, Margaret, MORALES, Renaud, COMPERE, Delphine, DENIS, Alexis, BLAIS, Stéphane, CLUZEAU, Philippe, COURTE, Karine

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Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base by O'Gara, M, Horton, J R, Roberts, R J, Cheng, X

“…Three structures have been determined for complexes between HhaI methyltransferase (M.HhaI) and oligonucleotides containing a G:A, G:U or G:AP (AP = abasic or…”
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The Consensus of the Church and Papal Infallibility: A Study in the Background of Vatican I by Richard F. Costigan, S.J. (review) by O’Gara, Margaret

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