Search Results - "O'Farrelly, Cliona"

Liver immunology and its role in inflammation and homeostasis by Robinson, Mark W, Harmon, Cathal, O’Farrelly, Cliona

“…The human liver is usually perceived as a non-immunological organ engaged primarily in metabolic, nutrient storage and detoxification activities. However, we…”
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β-Defensins: Farming the Microbiome for Homeostasis and Health by Meade, Kieran G, O'Farrelly, Cliona

“…Diverse commensal populations are now regarded as key to physiological homeostasis and protection against disease. Although bacteria are the most abundant…”
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Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection by Townsend, Liam, Dyer, Adam H, Jones, Karen, Dunne, Jean, Mooney, Aoife, Gaffney, Fiona, O'Connor, Laura, Leavy, Deirdre, O'Brien, Kate, Dowds, Joanne, Sugrue, Jamie A, Hopkins, David, Martin-Loeches, Ignacio, Ni Cheallaigh, Cliona, Nadarajan, Parthiban, McLaughlin, Anne Marie, Bourke, Nollaig M, Bergin, Colm, O'Farrelly, Cliona, Bannan, Ciaran, Conlon, Niall

“…Fatigue is a common symptom in those presenting with symptomatic COVID-19 infection. However, it is unknown if COVID-19 results in persistent fatigue in those…”
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Natural Killer Cells: Key Players in Endometriosis by Thiruchelvam, Uma, Wingfield, Mary, O'Farrelly, Cliona

“…Endometriosis affects more than 10% of women, causing significant pain and morbidity. It is also a significant cause of infertility. The aetiology of the…”
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Non-canonical Inflammasome-Mediated IL-1β Production by Primary Endometrial Epithelial and Stromal Fibroblast Cells Is NLRP3 and Caspase-4 Dependent by Kelly, Paul, Meade, Kieran G, O'Farrelly, Cliona

“…Inflammation of the post-partum uterus is a normal physiological event, crucial for tissue involution and repair. However, in the bovine, some cows fail to…”
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Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke by O'Shea, Donal, Cawood, Tom J, O'Farrelly, Cliona, Lynch, Lydia

“…Obese individuals who smoke have a 14 year reduction in life expectancy. Both obesity and smoking are independently associated with increased risk of…”
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Early Subretinal Allograft Rejection is Characterized by Innate Immune Activity by Kennelly, Kevin P., Holmes, Toby M., Wallace, Deborah M., O'farrelly, Cliona, Keegan, David J.

“…Successful subretinal transplantation is limited by considerable early graft loss despite pharmacological suppression of adaptive immunity. We postulated that…”
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Myeloid Engraftment in Humanized Mice: Impact of Granulocyte-Colony Stimulating Factor Treatment and Transgenic Mouse Strain by Coughlan, Alice M, Harmon, Cathal, Whelan, Sarah, O'Brien, Eóin C, O'Reilly, Vincent P, Crotty, Paul, Kelly, Pamela, Ryan, Michelle, Hickey, Fionnuala B, O'Farrelly, Cliona, Little, Mark A

“…Poor myeloid engraftment remains a barrier to experimental use of humanized mice. Focusing primarily on peripheral blood cells, we compared the engraftment…”
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The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity by O'Connell, Jean, Lynch, Lydia, Cawood, Tom J, Kwasnik, Anna, Nolan, Niamh, Geoghegan, Justin, McCormick, Aiden, O'Farrelly, Cliona, O'Shea, Donal

“…Several studies have reported the existence of a subgroup of obese individuals with normal metabolic profiles. It remains unclear what factors are responsible…”
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Receptor‐mediated recognition of mycobacterial pathogens by Killick, Kate E., Ní Cheallaigh, Clíona, O'Farrelly, Cliona, Hokamp, Karsten, MacHugh, David E., Harris, James

“…Summary Mycobacteria are a genus of bacteria that range from the non‐pathogenic Mycobacterium smegmatis to Mycobacterium tuberculosis, the causative agent of…”
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Toll-like receptor and antimicrobial peptide expression in the bovine endometrium by Davies, Darren, Meade, Kieran G, Herath, Shan, Eckersall, P David, Gonzalez, Deyarina, White, John O, Conlan, R Steven, O'Farrelly, Cliona, Sheldon, I Martin

“…The endometrium is commonly infected with bacteria leading to severe disease of the uterus in cattle and humans. The endometrial epithelium is the first line…”
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Reoxygenation‐specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia‐reperfusion injury by Leonard, Martin O., Kieran, Niamh E., Howell, Katherine, Burne, Melissa J., Varadarajan, Raghu, Dhakshinamoorthy, Saravanakumar, Porter, Alan G., O'Farrelly, Cliona, Rabb, Hamid, Taylor, Cormac T.

“…Tissue reoxygenation following hypoxia is associated with ischemia‐reperfusion injury (IRI) and may signal the development of ischemic preconditioning, an…”
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Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection by Dring, Megan M, Morrison, Maria H, McSharry, Brian P, Guinan, Kieran J, Hagan, Richard, O'Farrelly, Cliona, Gardiner, Clair M

“…Hepatitis C is a common infection with significant morbidity and mortality, and only a minority of patients successfully clear the infection. Identification of…”
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HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction by Gargan, Siobhan, Ahmed, Suaad, Mahony, Rebecca, Bannan, Ciaran, Napoletano, Silvia, O'Farrelly, Cliona, Borrow, Persephone, Bergin, Colm, Stevenson, Nigel J.

“…Anti-retroviral therapy successfully suppresses HIV-1 infection, but fails to provide a cure. During infection Type 1 IFNs normally play an essential role in…”
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Liver-Derived TGF-β Maintains the EomeshiTbetlo Phenotype of Liver Resident Natural Killer Cells by Harmon, Cathal, Jameson, Gráinne, Almuaili, Dalal, Houlihan, Diarmaid D., Hoti, Emir, Geoghegan, Justin, Robinson, Mark W., O'Farrelly, Cliona

“…The adult human liver hosts a complex repertoire of liver resident and transient natural killer (NK) cell populations with diverse phenotypes and functions…”
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Innate and adaptive lymphoid cells in the human liver by Doherty, Derek G., O'Farrelly, Cliona

“…Because of its location and function, the liver is continuously exposed to a large antigenic load that includes pathogens, toxins, tumor cells and harmless…”
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Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus by Sugrue, Jamie A., Smith, Megan, Posseme, Celine, Charbit, Bruno, Bourke, Nollaig M., Duffy, Darragh, O’Farrelly, Cliona

“…The Rhesus D antigen (RhD) has been associated with susceptibility to several viral infections. Reports suggest that RhD-negative individuals are better…”
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Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing by Connell, Sarah, Meade, Kieran G, Allan, Brenda, Lloyd, Andrew T, Kenny, Elaine, Cormican, Paul, Morris, Derek W, Bradley, Daniel G, O'Farrelly, Cliona

“…Campylobacter jejuni is the most common cause of human bacterial gastroenteritis and is associated with several post-infectious manifestations, including onset…”
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Induction of a Novel Chicken Toll-Like Receptor following Salmonella enterica Serovar Typhimurium Infection by Higgs, Rowan, Cormican, Paul, Cahalane, Sarah, Allan, Brenda, Lloyd, Andrew T, Meade, Kieran, James, Tharappel, Lynn, David J, Babiuk, Lorne A, O'Farrelly, Cliona

“…Toll-like receptors (TLRs) are a group of highly conserved molecules that initiate the innate immune response to pathogens by recognizing structural motifs…”
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Ribavirin enhances IFN-α signalling and MxA expression: a novel immune modulation mechanism during treatment of HCV by Stevenson, Nigel J, Murphy, Alison G, Bourke, Nollaig M, Keogh, Catherine A, Hegarty, John E, O'Farrelly, Cliona

“…The nucleoside analogue Ribavirin significantly increases patient response to IFN-α treatment of HCV, by directly inhibiting viral replication. Recent studies…”
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