Search Results - "O'Farrell, Patrick"

Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition by Seller, Charles A, O'Farrell, Patrick H

“…In preparation for dramatic morphogenetic events of gastrulation, rapid embryonic cell cycles slow at the mid-blastula transition (MBT). In Drosophila…”
Get full text

Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription by Cho, Chun-Yi, O’Farrell, Patrick H.

“…Binding of transcription factors (TFs) promotes the subsequent recruitment of coactivators and preinitiation complexes to initiate eukaryotic transcription,…”
Get full text

TALE-light imaging reveals maternally guided, H3K9me2/3-independent emergence of functional heterochromatin in Drosophila embryos by Yuan, Kai, O'Farrell, Patrick H

“…Metazoans start embryogenesis with a relatively naïve genome. The transcriptionally inert, late-replicating heterochromatic regions, including the constitutive…”
Get full text

From Egg to Gastrula: How the Cell Cycle Is Remodeled During the Drosophila Mid-Blastula Transition by Farrell, Jeffrey A, O'Farrell, Patrick H

“…Many, if not most, embryos begin development with extremely short cell cycles that exhibit unusually rapid DNA replication and no gap phases. The commitment to…”
Get full text

Selfish drive can trump function when animal mitochondrial genomes compete by Ma, Hansong, O'Farrell, Patrick H

“…Patrick H O'Farrell and Hansong Ma simultaneously introduce mitochondrial genomes from distantly related strains or other species into Drosophila melanogaster…”
Get full text

Growing an Embryo from a Single Cell: A Hurdle in Animal Life by O'Farrell, Patrick H

“…A requirement that an animal be able to feed to grow constrains how a cell can grow into an animal, and it forces an alternation between growth (increase in…”
Get full text

Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila by Seller, Charles A, Cho, Chun-Yi, O'Farrell, Patrick H

“…Acquisition of chromatin modifications during embryogenesis distinguishes different regions of an initially naïve genome. In many organisms, repetitive DNA is…”
Get full text

Navigating complexity through knowledge coproduction: Mainstreaming ecosystem services into disaster risk reduction by Reyers, Belinda, Jeanne L. Nel, Patrick J. O’Farrell, Nadia Sitas, Deon C. Nel

“…Achieving the policy and practice shifts needed to secure ecosystem services is hampered by the inherent complexities of ecosystem services and their…”
Get full text

Perceptions of impact: Invasive alien plants in the urban environment by Potgieter, Luke J., Gaertner, Mirijam, O'Farrell, Patrick J., Richardson, David M.

“…Many alien plant species are introduced to urban areas to create, augment or restore ecosystem services (ES). However, many of these species spread beyond…”
Get full text

Barriers to Male Transmission of Mitochondrial DNA in Sperm Development by DeLuca, Steven Z., O'Farrell, Patrick H.

“…Across the eukaryotic phylogeny, offspring usually inherit their mitochondrial genome from only one of two parents: in animals, the female. Although mechanisms…”
Get full text

Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio by Strong, Isaac J T, Lei, Xiaoyun, Chen, Fang, Yuan, Kai, O'Farrell, Patrick H

“…Externally deposited eggs begin development with an immense cytoplasm and a single overwhelmed nucleus. Rapid mitotic cycles restore normality as the ratio of…”
Get full text

Mitigation of age-dependent accumulation of defective mitochondrial genomes by Tsai, Pei-I, Korotkevich, Ekaterina, O’Farrell, Patrick H.

“…Unknown processes promote the accumulation of mitochondrial DNA (mtDNA) mutations during aging. Accumulation of defective mitochondrial genomes is thought to…”
Get full text

Impact of repeated hospital accreditation surveys on quality and reliability, an 8-year interrupted time series analysis by Devkaran, Subashnie, O’Farrell, Patrick N, Ellahham, Samer, Arcangel, Randy

“…ObjectiveTo evaluate whether hospital re-accreditation improves quality, patient safety and reliability over three accreditation cycles by testing the…”
Get full text

Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster by Ma, Hansong, Xu, Hong, O'Farrell, Patrick H

“…Patrick H O'Farrell and colleagues show not only that deleterious variants are selected against but that complementing mutant mitochondria are selected at…”
Get full text

Temporal control of late replication and coordination of origin firing by self-stabilizing Rif1-PP1 hubs in Drosophila by Cho, Chun-Yi, Seller, Charles A, O'Farrell, Patrick H

“…In the metazoan S phase, coordinated firing of clusters of origins replicates different parts of the genome in a temporal program. Despite advances, neither…”
Get full text

Quiescence: early evolutionary origins and universality do not imply uniformity by O'Farrell, Patrick H.

“…Cell cycle investigations have focused on relentless exponential proliferation of cells, an unsustainable situation in nature. Proliferation of cells, whether…”
Get full text

Selections that isolate recombinant mitochondrial genomes in animals by Ma, Hansong, O'Farrell, Patrick H

“…Homologous recombination is widespread and catalyzes evolution. Nonetheless, its existence in animal mitochondrial DNA is questioned. We designed selections…”
Get full text

The Mitochondrial DNA Polymerase Promotes Elimination of Paternal Mitochondrial Genomes by Yu, Zhongsheng, O’Farrell, Patrick H., Yakubovich, Nikita, DeLuca, Steven Z.

“…Mitochondrial DNA (mtDNA) is typically inherited from only one parent [1–3]. In animals, this is usually the mother. Maternal inheritance is often presented as…”
Get full text

Mechanism and Regulation of Cdc25/Twine Protein Destruction in Embryonic Cell-Cycle Remodeling by Farrell, Jeffrey A., O’Farrell, Patrick H.

“…In Drosophila embryos, the midblastula transition (MBT) dramatically remodels the cell cycle during the 14th interphase. Before the MBT, each cycle is composed…”
Get full text

The impact of hospital accreditation on quality measures: an interrupted time series analysis by Devkaran, Subashnie, O'Farrell, Patrick N

“…Developing countries frequently use hospital accreditation to guarantee quality and patient safety. However, implementation of accreditation standards is…”
Get full text