Search Results - "O'FLAHERTY, Linda"

Clinical applications of the CellSearch platform in cancer patients by Riethdorf, Sabine, O'Flaherty, Linda, Hille, Claudia, Pantel, Klaus

“…The CellSearch® system (CS) enables standardized enrichment and enumeration of circulating tumor cells (CTCs) that are repeatedly assessable via non-invasive…”
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Determination of PD-L1 Expression in Circulating Tumor Cells of NSCLC Patients and Correlation with Response to PD-1/PD-L1 Inhibitors by Janning, Melanie, Kobus, Franca, Babayan, Anna, Wikman, Harriet, Velthaus, Janna-Lisa, Bergmann, Sonja, Schatz, Stefanie, Falk, Markus, Berger, Lars-Arne, Böttcher, Lisa-Marie, Päsler, Sarina, Gorges, Tobias M, O'Flaherty, Linda, Hille, Claudia, Joosse, Simon A, Simon, Ronald, Tiemann, Markus, Bokemeyer, Carsten, Reck, Martin, Riethdorf, Sabine, Pantel, Klaus, Loges, Sonja

“…Circulating tumor cells (CTCs) hold great potential to answer key questions of how non-small cell lung cancer (NSCLC) evolves and develops resistance upon…”
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Biology and clinical significance of circulating tumor cell subpopulations in lung cancer by O’Flaherty, Linda, Wikman, Harriet, Pantel, Klaus

“…By identifying and tracking genetic changes in primary tumors and metastases, patients can be stratified for the most efficient therapeutic regimen by…”
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Massage has no observable effect on distress in children with burns: A randomized, observer-blinded trial by van Dijk, Monique, O’Flaherty, Linda Anne, Hoedemaker, Tessa, van Rosmalen, Joost, Rode, Heinz

“…•Massage with or without essential oils in children did not affect distress compared to controls as assessed by blinded observers.•It proved impossible to…”
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Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status by Bardella, Chiara, El-Bahrawy, Mona, Frizzell, Norma, Adam, Julie, Ternette, Nicola, Hatipoglu, Emine, Howarth, Kimberley, O'Flaherty, Linda, Roberts, Ian, Turner, Gareth, Taylor, Jennifer, Giaslakiotis, Konstantinos, Macaulay, Valentine M, Harris, Adrian L, Chandra, Ashish, Lehtonen, Heli J, Launonen, Virpi, Aaltonen, Lauri A, Pugh, Christopher W, Mihai, Radu, Trudgian, David, Kessler, Benedikt, Baynes, John W, Ratcliffe, Peter J, Tomlinson, Ian P, Pollard, Patrick J

“…Germline mutations in the FH gene encoding the Krebs cycle enzyme fumarate hydratase predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC)…”
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Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α) by Thalhammer, Armin, Bencokova, Zuzana, Poole, Rachel, Loenarz, Christoph, Adam, Julie, O'Flaherty, Linda, Schödel, Johannes, Mole, David, Giaslakiotis, Konstantinos, Schofield, Christopher J, Hammond, Ester M, Ratcliffe, Peter J, Pollard, Patrick J

“…Human 2-oxoglutarate oxygenases catalyse a range of biological oxidations including the demethylation of histone and nucleic acid substrates and the…”
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Aromatherapy massage seems to enhance relaxation in children with burns: An observational pilot study by O’Flaherty, Linda-Anne, van Dijk, Monique, Albertyn, Rene, Millar, Alastair, Rode, Heinz

“…Abstract Objective This observational pilot study investigated effects of aromatherapy massage in paediatric burn patients. Methods The setting was a 17 beds…”
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Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism by O'Flaherty, Linda, Adam, Julie, Heather, Lisa C., Zhdanov, Alexander V., Chung, Yuen-Li, Miranda, Melroy X., Croft, Joanne, Olpin, Simon, Clarke, Kieran, Pugh, Christopher W., Griffiths, John, Papkovsky, Dmitri, Ashrafian, Houman, Ratcliffe, Peter J., Pollard, Patrick J.

“…Mutations in the gene encoding the Krebs cycle enzyme fumarate hydratase (FH) predispose to hereditary leiomyomatosis and renal cell cancer in affected…”
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Cells Lacking the Fumarase Tumor Suppressor Are Protected from Apoptosis through a Hypoxia-Inducible Factor-Independent, AMPK-Dependent Mechanism by Bardella, Chiara, Olivero, Martina, Lorenzato, Annalisa, Geuna, Massimo, Adam, Julie, O'Flaherty, Linda, Rustin, Pierre, Tomlinson, Ian, Pollard, Patrick J., Di Renzo, Maria Flavia

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Glycogen synthase kinase 3 protein kinase activity is frequently elevated in human non-small cell lung carcinoma and supports tumour cell proliferation by Vincent, Emma E, Elder, Douglas J E, O'Flaherty, Linda, Pardo, Olivier E, Dzien, Piotr, Phillips, Lois, Morgan, Carys, Pawade, Joya, May, Margaret T, Sohail, Muhammad, Hetzel, Martin R, Seckl, Michael J, Tavaré, Jeremy M

“…Glycogen synthase kinase 3 (GSK3) is a central regulator of cellular metabolism, development and growth. GSK3 activity was thought to oppose tumourigenesis,…”
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Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis by ASHRAFIAN, Houman, O'FLAHERTY, Linda, MIRANDA, Melroy, HOWARTH, Kimberley, SHUKLA, Deepa, TROY, Helen, GRIFFITHS, John, SPENCER-DENE, Bradley, YUSUF, Mohammed, VOLPI, Emanuela, MAXWELL, Patrick H, STAMP, Gordon, ADAM, Julie, POULSOM, Richard, PUGH, Christopher W, COSTA, Barbara, BARDELLA, Chiara, FLAVIA DI RENZO, Maria, KOTLIKOFF, Michael I, LAUNONEN, Virpi, AALTONEN, Lauri, EL-BAHRAWY, Mona, TOMLINSON, Ian, STEEPLES, Violetta, POLLARD, Patrick J, CHUNG, Yuen-Li, EAST, Phil, VANHARANTA, Sakari, LEHTONEN, Heli, NYE, Emma, HATIPOGLU, Emine

“…Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is caused by mutations in the Krebs cycle enzyme fumarate hydratase (FH). It has been proposed that…”
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Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer by O'Flaherty, Linda, Shnyder, Steven D, Cooper, Patricia A, Cross, Stephen J, Wakefield, James G, Pardo, Olivier E, Seckl, Michael J, Tavaré, Jeremy M

“…Glycogen synthase kinase-3 (GSK3) is over-expressed and hyperactivated in non-small cell lung carcinoma (NSCLC) and plays a role in ensuring the correct…”
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Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency by Ternette, Nicola, Yang, Ming, Laroyia, Mahima, Kitagawa, Mitsuhiro, O’Flaherty, Linda, Wolhulter, Kathryn, Igarashi, Kaori, Saito, Kaori, Kato, Keiko, Fischer, Roman, Berquand, Alexandre, Kessler, Benedikt M., Lappin, Terry, Frizzell, Norma, Soga, Tomoyoshi, Adam, Julie, Pollard, Patrick J.

“…The gene encoding the Krebs cycle enzyme fumarate hydratase (FH) is mutated in hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity…”
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A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia by Adam, Julie, Yang, Ming, Bauerschmidt, Christina, Kitagawa, Mitsuhiro, O’Flaherty, Linda, Maheswaran, Pratheesh, Özkan, Gizem, Sahgal, Natasha, Baban, Dilair, Kato, Keiko, Saito, Kaori, Iino, Keiko, Igarashi, Kaori, Stratford, Michael, Pugh, Christopher, Tennant, Daniel A., Ludwig, Christian, Davies, Benjamin, Ratcliffe, Peter J., El-Bahrawy, Mona, Ashrafian, Houman, Soga, Tomoyoshi, Pollard, Patrick J.

“…The identification of mutated metabolic enzymes in hereditary cancer syndromes has established a direct link between metabolic dysregulation and cancer…”
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Aromatherapy massage seems effective in critically ill children: an observational before‐after study by Heijden, Marianne J. E., O’Flaherty, Linda‐Anne, Rosmalen, Joost, Vos, Simone, McCulloch, Mignon, Dijk, Monique

“…Children treated in a pediatric intensive care unit (PICU) are at risk of distress and pain. This study investigated if aromatherapy massage can reduce…”
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Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling by Adam, Julie, Hatipoglu, Emine, O'Flaherty, Linda, Ternette, Nicola, Sahgal, Natasha, Lockstone, Helen, Baban, Dilair, Nye, Emma, Stamp, Gordon W., Wolhuter, Kathryn, Stevens, Marcus, Fischer, Roman, Carmeliet, Peter, Maxwell, Patrick H., Pugh, Chris W., Frizzell, Norma, Soga, Tomoyoshi, Kessler, Benedikt M., El-Bahrawy, Mona, Ratcliffe, Peter J., Pollard, Patrick J.

“…The Krebs cycle enzyme fumarate hydratase (FH) is a human tumor suppressor whose inactivation is associated with the development of leiomyomata, renal cysts,…”
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Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1[alpha] by Thalhammer, Armin, Bencokova, Zuzana, Poole, Rachel, Loenarz, Christoph, Adam, Julie, O'Flaherty, Linda, Schödel, Johannes, Mole, David, Giaslakiotis, Konstantinos, Schofield, Christopher J, Hammond, Ester M, Ratcliffe, Peter J, Pollard, Patrick J

“…Human 2-oxoglutarate oxygenases catalyse a range of biological oxidations including the demethylation of histone and nucleic acid substrates and the…”
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Development of novel in vitro and in vivo models for determining primary events in HLRCC tumourigenesis by O'Flaherty, Linda H

“…Germline mutations of fumarate hydratase (FH), encoding an enzyme of the tricarboxylic acid (TCA) cycle, predispose affected individuals to hereditary…”
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