Search Results - "O'Duibhir, Eoghan"

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration by Raven, Alexander, Lu, Wei-Yu, Man, Tak Yung, Ferreira-Gonzalez, Sofia, O’Duibhir, Eoghan, Dwyer, Benjamin J., Thomson, John P., Meehan, Richard R., Bogorad, Roman, Koteliansky, Victor, Kotelevtsev, Yuri, ffrench-Constant, Charles, Boulter, Luke, Forbes, Stuart J.

“…Two independent systems impairing hepatocyte proliferation during liver injury cause physiologically significant levels of functional hepatocyte regeneration…”
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Sequence-Directed Action of RSC Remodeler and General Regulatory Factors Modulates +1 Nucleosome Position to Facilitate Transcription by Kubik, Slawomir, O’Duibhir, Eoghan, de Jonge, Wim J., Mattarocci, Stefano, Albert, Benjamin, Falcone, Jean-Luc, Bruzzone, Maria Jessica, Holstege, Frank C.P., Shore, David

“…Accessible chromatin is important for RNA polymerase II recruitment and transcription initiation at eukaryotic promoters. We investigated the mechanistic links…”
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The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury by Campana, Lara, Starkey Lewis, Philip J, Pellicoro, Antonella, Aucott, Rebecca L, Man, Janet, O'Duibhir, Eoghan, Mok, Sarah E, Ferreira-Gonzalez, Sofia, Livingstone, Eilidh, Greenhalgh, Stephen N, Hull, Katherine L, Kendall, Timothy J, Vernimmen, Douglas, Henderson, Neil C, Boulter, Luke, Gregory, Christopher D, Feng, Yi, Anderton, Stephen M, Forbes, Stuart J, Iredale, John P

“…The disposal of apoptotic bodies by professional phagocytes is crucial to effective inflammation resolution. Our ability to improve the disposal of apoptotic…”
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Paracrine cellular senescence exacerbates biliary injury and impairs regeneration by Ferreira-Gonzalez, Sofia, Lu, Wei-Yu, Raven, Alexander, Dwyer, Benjamin, Man, Tak Yung, O’Duibhir, Eoghan, Lewis, Philip J. Starkey, Campana, Lara, Kendall, Tim J., Bird, Thomas G., Tarrats, Nuria, Acosta, Juan-Carlos, Boulter, Luke, Forbes, Stuart J.

“…Cellular senescence is a mechanism that provides an irreversible barrier to cell cycle progression to prevent undesired proliferation. However, under…”
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Alternatively activated macrophages promote resolution of necrosis following acute liver injury by Starkey Lewis, Philip, Campana, Lara, Aleksieva, Niya, Cartwright, Jennifer Ann, Mackinnon, Alison, O'Duibhir, Eoghan, Kendall, Timothy, Vermeren, Matthieu, Thomson, Adrian, Gadd, Victoria, Dwyer, Benjamin, Aird, Rhona, Man, Tak-Yung, Rossi, Adriano Giorgio, Forrester, Lesley, Park, B. Kevin, Forbes, Stuart John

“…Following acetaminophen (APAP) overdose, acute liver injury (ALI) can occur in patients that present too late for N-acetylcysteine treatment, potentially…”
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An Image-Based miRNA Screen Identifies miRNA-135s As Regulators of CNS Axon Growth and Regeneration by Targeting Krüppel-like Factor 4 by van Battum, Eljo Y, Verhagen, Marieke G, Vangoor, Vamshidhar R, Fujita, Yuki, Derijck, Alwin A H A, O'Duibhir, Eoghan, Giuliani, Giuliano, de Gunst, Thijs, Adolfs, Youri, Lelieveld, Daphne, Egan, David, Schaapveld, Roel Q J, Yamashita, Toshihide, Pasterkamp, R Jeroen

“…During embryonic development, axons extend over long distances to establish functional connections. In contrast, axon regeneration in the adult mammalian CNS…”
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Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response by Kan, Anne A., van Erp, Susan, Derijck, Alwin A. H. A., de Wit, Marina, Hessel, Ellen V. S., O’Duibhir, Eoghan, de Jager, Wilco, Van Rijen, Peter C., Gosselaar, Peter H., de Graan, Pierre N. E., Pasterkamp, R. Jeroen

“…Mesial temporal lobe epilepsy (mTLE) is a chronic neurological disorder characterized by recurrent seizures. The pathogenic mechanisms underlying mTLE may…”
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Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells by Lyall, Marcus J., Cartier, Jessy, Thomson, John P., Cameron, Kate, Meseguer-Ripolles, Jose, O'Duibhir, Eoghan, Szkolnicka, Dagmara, Villarin, Baltasar Lucendo, Wang, Yu, Blanco, Giovanny Rodriguez, Dunn, Warwick B., Meehan, Richard R., Hay, David C., Drake, Amanda J.

“…Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in developed countries. An in vitro NAFLD model would permit mechanistic…”
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An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein by Dewari, Pooran Singh, Southgate, Benjamin, Mccarten, Katrina, Monogarov, German, O'Duibhir, Eoghan, Quinn, Niall, Tyrer, Ashley, Leitner, Marie-Christin, Plumb, Colin, Kalantzaki, Maria, Blin, Carla, Finch, Rebecca, Bressan, Raul Bardini, Morrison, Gillian, Jacobi, Ashley M, Behlke, Mark A, von Kriegsheim, Alex, Tomlinson, Simon, Krijgsveld, Jeroen, Pollard, Steven M

“…CRISPR/Cas9 can be used for precise genetic knock-in of epitope tags into endogenous genes, simplifying experimental analysis of protein function. However,…”
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Large-Scale Genetic Perturbations Reveal Regulatory Networks and an Abundance of Gene-Specific Repressors by Kemmeren, Patrick, Sameith, Katrin, van de Pasch, Loes A.L., Benschop, Joris J., Lenstra, Tineke L., Margaritis, Thanasis, O’Duibhir, Eoghan, Apweiler, Eva, van Wageningen, Sake, Ko, Cheuk W., van Heesch, Sebastiaan, Kashani, Mehdi M., Ampatziadis-Michailidis, Giannis, Brok, Mariel O., Brabers, Nathalie A.C.H., Miles, Anthony J., Bouwmeester, Diane, van Hooff, Sander R., van Bakel, Harm, Sluiters, Erik, Bakker, Linda V., Snel, Berend, Lijnzaad, Philip, van Leenen, Dik, Groot Koerkamp, Marian J.A., Holstege, Frank C.P.

“…To understand regulatory systems, it would be useful to uniformly determine how different components contribute to the expression of all other genes. We…”
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TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression by Dwyer, Benjamin J., Jarman, Edward J., Gogoi-Tiwari, Jully, Ferreira-Gonzalez, Sofia, Boulter, Luke, Guest, Rachel V., Kendall, Timothy J., Kurian, Dominic, Kilpatrick, Alastair M., Robson, Andrew J., O’Duibhir, Eoghan, Man, Tak Yung, Campana, Lara, Starkey Lewis, Philip J., Wigmore, Stephen J., Olynyk, John K., Ramm, Grant A., Tirnitz-Parker, Janina E.E., Forbes, Stuart J.

“…Cholangiocarcinoma (CCA) is a cancer of the hepatic bile ducts that is rarely resectable and is associated with poor prognosis. Tumour necrosis factor-like…”
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Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease by Hallett, John M., Ferreira-Gonzalez, Sofia, Man, Tak Yung, Kilpatrick, Alastair M., Esser, Hannah, Thirlwell, Kayleigh, Macmillan, Mark T., Rodrigo-Torres, Daniel, Dwyer, Benjamin J., Gadd, Victoria L., Ashmore-Harris, Candice, Lu, Wei-Yu, Thomson, John P., Jansen, Maurits A., O’Duibhir, Eoghan, Starkey Lewis, Philip J., Campana, Lara, Aird, Rhona E., Bate, Thomas S.R., Fraser, Alasdair R., Campbell, John D.M., Oniscu, Gabriel C., Hay, David C., Callanan, Anthony, Forbes, Stuart J.

“…Biliary diseases can cause inflammation, fibrosis, bile duct destruction, and eventually liver failure. There are no curative treatments for biliary disease…”
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Elevated FOXG1 in glioblastoma stem cells cooperates with Wnt/β-catenin to induce exit from quiescence by Robertson, Faye L., O’Duibhir, Eoghan, Gangoso, Ester, Bressan, Raul Bardini, Bulstrode, Harry, Marqués-Torrejón, Maria-Ángeles, Ferguson, Kirsty M., Blin, Carla, Grant, Vivien, Alfazema, Neza, Morrison, Gillian M., Pollard, Steven M.

“…Glioblastoma (GBM) stem cells (GSCs) display phenotypic and molecular features reminiscent of normal neural stem cells and exhibit a spectrum of cell cycle…”
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Cell cycle population effects in perturbation studies by O'Duibhir, Eoghan, Lijnzaad, Philip, Benschop, Joris J, Lenstra, Tineke L, van Leenen, Dik, Groot Koerkamp, Marian JA, Margaritis, Thanasis, Brok, Mariel O, Kemmeren, Patrick, Holstege, Frank CP

“…Growth condition perturbation or gene function disruption are commonly used strategies to study cellular systems. Although it is widely appreciated that such…”
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Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells by Oosthuyzen, Wilna, Scullion, Kathleen M, Ivy, Jessica R, Morrison, Emma E, Hunter, Robert W, Starkey Lewis, Philip J, O'Duibhir, Eoghan, Street, Jonathan M, Caporali, Andrea, Gregory, Christopher D, Forbes, Stuart J, Webb, David J, Bailey, Matthew A, Dear, James W

“…Extracellular vesicles (ECVs) facilitate intercellular communication along the nephron, with the potential to change the function of the recipient cell…”
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Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II by Meinel, Dominik M, Burkert-Kautzsch, Cornelia, Kieser, Anja, O'Duibhir, Eoghan, Siebert, Matthias, Mayer, Andreas, Cramer, Patrick, Söding, Johannes, Holstege, Frank C P, Sträßer, Katja

“…Messenger RNA (mRNA) synthesis and export are tightly linked, but the molecular mechanisms of this coupling are largely unknown. In Saccharomyces cerevisiae,…”
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Corrigendum: Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration by Raven, Alexander, Lu, Wei-Yu, Man, Tak Yung, Ferreira-Gonzalez, Sofia, O'Duibhir, Eoghan, Dwyer, Benjamin J, Thomson, John P, Meehan, Richard R, Bogorad, Roman, Koteliansky, Victor, Kotelevtsev, Yuri, Ffrench-Constant, Charles, Boulter, Luke, Forbes, Stuart J

“…This corrects the article DOI: 10.1038/nature23015…”
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Pmch-deficiency in rats is associated with normal adipocyte differentiation and lower sympathetic adipose drive by Mul, Joram D, O'Duibhir, Eoghan, Shrestha, Yogendra B, Koppen, Arjen, Vargoviç, Peter, Toonen, Pim W, Zarebidaki, Eleen, Kvetnansky, Richard, Kalkhoven, Eric, Cuppen, Edwin, Bartness, Timothy J

“…The orexigenic neuropeptide melanin-concentrating hormone (MCH), a product of Pmch, is an important mediator of energy homeostasis. Pmch-deficient rodents are…”
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Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury by Haideri, Sharmin S., McKinnon, Alison C., Taylor, A. Helen, Kirkwood, Phoebe, Starkey Lewis, Philip J., O’Duibhir, Eoghan, Vernay, Bertrand, Forbes, Stuart, Forrester, Lesley M.

“…Chronic liver injury can be caused by viral hepatitis, alcohol, obesity, and metabolic disorders resulting in fibrosis, hepatic scarring, and cirrhosis. Novel…”
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Accelerating glioblastoma drug discovery: Convergence of patient-derived models, genome editing and phenotypic screening by O'Duibhir, Eoghan, Carragher, Neil O., Pollard, Steven M.

“…Patients diagnosed with glioblastoma (GBM) continue to face a bleak prognosis. It is critical that new effective therapeutic strategies are developed. GBM stem…”
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