Search Results - "O'Driscoll, Cliona M"

Hydroquinone Increases 5-Hydroxymethylcytosine Formation through Ten Eleven Translocation 1 (TET1) 5-Methylcytosine Dioxygenase by Coulter, Jonathan B., O'Driscoll, Cliona M., Bressler, Joseph P.

“…Hydroquinone is a benzene metabolite shown to lead to decreased DNA methylation. Results: Hydroquinone exposure increases Ten Eleven Translocation 1…”
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Truncated TrkB.T1-Mediated Astrocyte Dysfunction Contributes to Impaired Motor Function and Neuropathic Pain after Spinal Cord Injury by Matyas, Jessica J, O'Driscoll, Cliona M, Yu, Laina, Coll-Miro, Marina, Daugherty, Sean, Renn, Cynthia L, Faden, Alan I, Dorsey, Susan G, Wu, Junfang

“…Following spinal cord injury (SCI), astrocytes demonstrate long-lasting reactive changes, which are associated with the persistence of neuropathic pain and…”
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Methyl CpG binding protein 2 deficiency enhances expression of inflammatory cytokines by sustaining NF-κB signaling in myeloid derived cells by O'Driscoll, Cliona M, Lima, Marina Palma, Kaufmann, Walter E, Bressler, Joseph P

“…Abstract Knocking down methyl CpG binding protein 2 (MeCP2) enhances NF-κB activation in human peripheral blood mononuclear cells (PBMC). In this study, we…”
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Small molecule glutaminase inhibitors block glutamate release from stimulated microglia by Thomas, Ajit G., O’Driscoll, Cliona M., Bressler, Joseph, Kaufmann, Walter E., Rojas, Camilo J., Slusher, Barbara S.

“…•Glutamate release in microglia was induced by TNF-α, TLR agonists and PMA.•Glutamate release was blocked by active, small molecule glutaminase…”
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MeCP2 deficiency enhances glutamate release through NF-κB signaling in myeloid derived cells by O’Driscoll, Cliona M, Kaufmann, Walter E, Bressler, Joseph P

“…Abstract The signaling pathway involved in regulating glutamate release was investigated. Glutaminase mRNA levels were higher in microglia isolated from mice…”
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Induction of a trophoblast-like phenotype by hydralazine in the p19 embryonic carcinoma cell line by O'Driscoll, Cliona M., Coulter, Jonathan B., Bressler, Joseph P.

“…Chemicals that affect cellular differentiation through epigenetic mechanisms have potential utility in treating a wide range of diseases. Hydralazine decreases…”
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