Search Results - "O'Driscoll, Cliona"

Hydroquinone Increases 5-Hydroxymethylcytosine Formation through Ten Eleven Translocation 1 (TET1) 5-Methylcytosine Dioxygenase by Coulter, Jonathan B., O'Driscoll, Cliona M., Bressler, Joseph P.

“…Hydroquinone is a benzene metabolite shown to lead to decreased DNA methylation. Results: Hydroquinone exposure increases Ten Eleven Translocation 1…”
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Methyl CpG binding protein 2 deficiency enhances expression of inflammatory cytokines by sustaining NF-κB signaling in myeloid derived cells by O'Driscoll, Cliona M, Lima, Marina Palma, Kaufmann, Walter E, Bressler, Joseph P

“…Abstract Knocking down methyl CpG binding protein 2 (MeCP2) enhances NF-κB activation in human peripheral blood mononuclear cells (PBMC). In this study, we…”
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Neuronal pentraxin 1 induction in hypoxic–ischemic neuronal death is regulated via a glycogen synthase kinase-3α/β dependent mechanism by Russell, Juliet C., Kishimoto, Koji, O'Driscoll, Cliona, Hossain, Mir Ahamed

“…Intracellular signaling pathways that regulate the production of lethal proteins in central neurons are not fully characterized. Previously, we reported…”
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Temporal and Regional Alterations in NMDA Receptor Expression in Mecp2‐Null Mice by Blue, Mary E., Kaufmann, Walter E., Bressler, Joseph, Eyring, Charlotte, O'driscoll, Cliona, Naidu, Sakkubai, Johnston, Michael V.

“…Our previous postmortem study of girls with Rett Syndrome (RTT), a development disorder caused by MECP2 mutations, found increases in the density of…”
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Twenty-four hour quantitative-EEG and in-vivo glutamate biosensor detects activity and circadian rhythm dependent biomarkers of pathogenesis in Mecp2 null mice by Johnston, Michael V, Ammanuel, Simon, O'Driscoll, Cliona, Wozniak, Amy, Naidu, Sakkubai, Kadam, Shilpa D

“…Mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (Mecp2) cause most cases of Rett syndrome (RTT). Currently there is no cure for RTT…”
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Toward a 3D model of human brain development for studying gene/environment interactions by Hogberg, Helena T, Bressler, Joseph, Christian, Kimberly M, Harris, Georgina, Makri, Georgia, O'Driscoll, Cliona, Pamies, David, Smirnova, Lena, Wen, Zhexing, Hartung, Thomas

“…This project aims to establish and characterize an in vitro model of the developing human brain for the purpose of testing drugs and chemicals. To accurately…”
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Hairless expression attenuates apoptosis in a mouse model and the COS cell line; involvement of p53 by O'Driscoll, Cliona, Bressler, Joseph P

“…Neurons are more likely to die through apoptosis in the immature brain after injury whereas adult neurons in the mature brain die by necrosis. Several studies…”
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Truncated TrkB.T1-Mediated Astrocyte Dysfunction Contributes to Impaired Motor Function and Neuropathic Pain after Spinal Cord Injury by Matyas, Jessica J, O'Driscoll, Cliona M, Yu, Laina, Coll-Miro, Marina, Daugherty, Sean, Renn, Cynthia L, Faden, Alan I, Dorsey, Susan G, Wu, Junfang

“…Following spinal cord injury (SCI), astrocytes demonstrate long-lasting reactive changes, which are associated with the persistence of neuropathic pain and…”
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Maternal Antibody Reactivity to Lymphocytes of Offspring With Autism by Bressler, Joseph P., PhD, Gillin, Pam K., MS, O'Driscoll, Cliona, PhD, Kiihl, Samara, PhD, Solomon, Megan, BS, Zimmerman, Andrew W., MD

“…Abstract The study examined whether maternal serum antibodies from mothers of autistic children preferentially bind to lymphocytes of their autistic children…”
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Small molecule glutaminase inhibitors block glutamate release from stimulated microglia by Thomas, Ajit G., O’Driscoll, Cliona M., Bressler, Joseph, Kaufmann, Walter E., Rojas, Camilo J., Slusher, Barbara S.

“…•Glutamate release in microglia was induced by TNF-α, TLR agonists and PMA.•Glutamate release was blocked by active, small molecule glutaminase…”
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MeCP2 deficiency enhances glutamate release through NF-κB signaling in myeloid derived cells by O’Driscoll, Cliona M, Kaufmann, Walter E, Bressler, Joseph P

“…Abstract The signaling pathway involved in regulating glutamate release was investigated. Glutaminase mRNA levels were higher in microglia isolated from mice…”
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Assessing blood-brain barrier function using in vitro assays by Bressler, Joseph, Clark, Katherine, O'Driscoll, Cliona

“…The impermeability of the blood-brain barrier (BBB) is due to a number of properties including tight junctions on adjoining endothelial cells, absence of…”
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Induction of a trophoblast-like phenotype by hydralazine in the p19 embryonic carcinoma cell line by O'Driscoll, Cliona M., Coulter, Jonathan B., Bressler, Joseph P.

“…Chemicals that affect cellular differentiation through epigenetic mechanisms have potential utility in treating a wide range of diseases. Hydralazine decreases…”
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Relationship between Mecp2 and NFκb signaling during neural differentiation of P19 cells by O'Driscoll, Cliona, Kaufmann, Walter E, Bressler, Joseph

“…Abstract The pluripotent P19 embryo carcinoma cell line was studied to determine a signaling pathway regulating MeCP2 expression. P19 cells were induced to…”
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Evaluation of the Interactions Between Multiwalled Carbon Nanotubes and Caco-2 Cells by Clark, Katherine A., O'Driscoll, Cliona, Cooke, Carol A., Smith, Bill A., Wepasnick, Kevin, Fairbrother, D. Howard, Lees, Peter S. J., Bressler, Joseph P.

“…The aim of this study was to determine whether multiwalled carbon nanotubes (MWNCT) are taken up by and are toxic to human intestinal enterocytes using the…”
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