Search Results - "O'Donnell, VB"

Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far? by Schebb, Nils Helge, Kühn, Hartmut, Kahnt, Astrid S, Rund, Katharina M, O'Donnell, Valerie B, Flamand, Nicolas, Peters-Golden, Marc, Jakobsson, Per-Johan, Weylandt, Karsten H, Rohwer, Nadine, Murphy, Robert C, Geisslinger, Gerd, FitzGerald, Garret A, Hanson, Julien, Dahlgren, Claes, Alnouri, Mohamad Wessam, Offermanns, Stefan, Steinhilber, Dieter

“…Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and…”
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Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples by O’Donnell, Valerie B., Schebb, Nils H., Milne, Ginger L., Murphy, Michael P., Thomas, Christopher P., Steinhilber, Dieter, Gelhaus, Stacy L., Kühn, Hartmut, Gelb, Michael H., Jakobsson, Per-Johan, Blair, Ian A., Murphy, Robert C., Freeman, Bruce A., Brash, Alan R., FitzGerald, Garret A.

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Antagonistic Roles of Human Platelet Integrin αIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow by Schönichen, Claudia, Montague, Samantha J., Brouns, Sanne L.N., Burston, James J., Cosemans, Judith M.E.M., Jurk, Kerstin, Kehrel, Beate E., Koenen, Rory R., Ní Áinle, Fionnuala, O’Donnell, Valerie B., Soehnlein, Oliver, Watson, Steve P., Kuijpers, Marijke J.E., Heemskerk, Johan W.M., Nagy, Magdolna

“…Platelets and neutrophils are the first blood cells accumulating at sites of arterial thrombus formation, and both cell types contribute to the pathology of…”
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Interactions Between Nitric Oxide and Lipid Oxidation Pathways: Implications for Vascular Disease by O’Donnell, Valerie B, Freeman, Bruce A

“…ABSTRACT—Nitric oxide (NO) signaling pathways and lipid oxidation reactions are of central importance in both the maintenance of vascular homeostasis and the…”
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Contractile, but not endothelial, dysfunction in early inflammatory arthritis: a possible role for matrix metalloproteinase‐9 by Reynolds, SL, Williams, AS, Williams, H, Smale, S, Stephenson, HJ, Amos, N, George, SJ, O'Donnell, VB, Lang, D

“…BACKGROUND AND PURPOSE Excess morbidity/mortality in rheumatoid arthritis (RA) is associated with increased incidence of cardiovascular disease. In this…”
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Nitrolinoleate Inhibits Superoxide Generation, Degranulation, and Integrin Expression by Human Neutrophils: Novel Antiinflammatory Properties of Nitric Oxide-Derived Reactive Species in Vascular Cells by Coles, Barbara, Bloodsworth, Allison, Clark, Stephen R, Lewis, Malcolm J, Cross, Andrew R, Freeman, Bruce A, O’Donnell, Valerie B

“…ABSTRACT—Nitration of unsaturated fatty acids such as linoleate by NO-derived reactive species forms novel derivatives (including nitrolinoleate [LNO2]) that…”
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Free radicals and lipid signaling in endothelial cells by O'Donnell, Valerie B

“…Lipid mediators generated by oxidative pathways play essential roles in vascular homeostasis and disease through activating signal transduction pathways that…”
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Nitrolinoleate, a Nitric Oxide-Derived Mediator of Cell Function: Synthesis, Characterization, and Vasomotor Activity by Lim, Dong Gun, Sweeney, Scott, Bloodsworth, Allison, White, C. Roger, Chumley, Phillip H., Krishna, N. Rama, Schopfer, Francisco, O'Donnell, Valerie B., Eiserich, Jason P., Freeman, Bruce A.

“…Nitric oxide ($^\bullet NO$) and$^\bullet NO$-derived reactive species rapidly react with lipids during both autocatalytic and enzymatic oxidation reactions to…”
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Nitric Oxide Regulation of Free Radical- and Enzyme-Mediated Lipid and Lipoprotein Oxidation by Bloodsworth, Allison, O’Donnell, Valerie B, Freeman, Bruce A

“…The regulation of nonenzymatic and enzymatic lipid oxidation reactions by nitric oxide (·NO) is potent and pervasive and reveals novel non–cGMP-dependent…”
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The Effect Of The 15-Lipoxygenase 1 (15lo1) Inhibitor Blx2477 On Il-13-Induced Periostin Mrna Expression In Human Airway Epithelial Cells (haecs) by Minami, Y, Etling, EB, O'Donnell, VB, Yecies, EB, Trudeau, JB, Claesson, H, Zhao, J, Wenzel, SE

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Nitration of Unsaturated Fatty Acids by Nitric Oxide-Derived Reactive Nitrogen Species Peroxynitrite, Nitrous Acid, Nitrogen Dioxide, and Nitronium Ion by O'Donnell, Valerie B, Eiserich, Jason P, Chumley, Phillip H, Jablonsky, Michael J, Krishna, N. Rama, Kirk, Marion, Barnes, Stephen, Darley-Usmar, Victor M, Freeman, Bruce A

“…Reactive nitrogen species derived from nitric oxide are potent oxidants formed during inflammation that can oxidize membrane and lipoprotein lipids in vivo…”
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Nitrolinoleate Inhibits Platelet Activation by Attenuating Calcium Mobilization and Inducing Phosphorylation of Vasodilator-stimulated Phosphoprotein through Elevation of cAMP by Coles, Barbara, Bloodsworth, Allison, Eiserich, Jason P., Coffey, Marcus J., McLoughlin, Rachel M., Giddings, John C., Lewis, Malcolm J., Haslam, Richard J., Freeman, Bruce A., O'Donnell, Valerie B.

“…Reactive species formed from nitric oxide (NO) nitrate unsaturated fatty acids such as linoleate (LA) to nitrated derivatives including nitrolinoleate (LNO2)…”
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Lipoxygenase Metabolite Profile In Human Airway Epithelial Cells (haecs) by Etling, EB, Tyrrell, V, Yecies, EB, Trudeau, JB, Claesson, HE, O'Donnell, VB, Zhao, J, Wenzel, SE

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Elevated Endothelial Nitric Oxide Bioactivity and Resistance to Angiotensin-Dependent Hypertension in 12/15-Lipoxygenase Knockout Mice by Anning, Peter B., Coles, Barbara, Bermudez-Fajardo, Alexandra, Martin, Patricia E.M., Levison, Bruce S., Hazen, Stanley L., Funk, Colin D., Kühn, Hartmut, O'Donnell, Valerie B.

“…12/15-Lipoxygenase (12/15-LOX) plays a pathogenic role in atherosclerosis. To characterize whether 12/15-LOX also contributes to endothelial dysfunction and…”
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Platelet 12-Lipoxygenase Activation via Glycoprotein VI: Involvement of Multiple Signaling Pathways in Agonist Control of H(P)ETE Synthesis by Coffey, Marcus J, Jarvis, Gavin E, Gibbins, Jonathan M, Coles, Barbara, Barrett, Natasha E, Wylie, Oliver R.E, O’Donnell, Valerie B

“…Lipoxygenases (LOX) contribute to vascular disease and inflammation through generation of bioactive lipids, including 12-hydro(pero)xyeicosatetraenoic acid…”
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In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets by Williams, P. Claire, Coffey, Marcus J., Coles, Barbara, Sanchez, Stephanie, Morrow, Jason D., Cockcroft, John R., Lewis, Malcolm J., O'Donnell, Valerie B.

“…Antiplatelet therapies improve endothelial function in atherosclerosis, suggesting that platelets regulate vascular nitric oxide (NO) bioactivity in vivo…”
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Catalytic Consumption of Nitric Oxide by Prostaglandin H Synthase-1 Regulates Platelet Function by O'Donnell, V B, Coles, B, Lewis, M J, Crews, B C, Marnett, L J, Freeman, B A

“…Nitric oxide ( ⋅ NO) plays a central role in vascular homeostasis via regulation of smooth muscle relaxation and platelet aggregation. Although mechanisms…”
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Catalytic Consumption of Nitric Oxide by 12/15-Lipoxygenase: Inhibition of Monocyte Soluble Guanylate Cyclase Activation by Coffey, Marcus J., Natarajan, Rama, Chumley, Phillip H., Coles, Barbara, Thimmalapura, Pushpa-Rekha, Nowell, Mari, Kühn, Hartmut, Lewis, Malcolm J., Freeman, Bruce A., O'Donnell, Valerie B.

“…12/15-Lipoxygenase (LOX) activity is elevated in vascular diseases associated with impaired nitric oxide (·NO) bioactivity, such as hypertension and…”
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15-Lipoxygenase Catalytically Consumes Nitric Oxide and Impairs Activation of Guanylate Cyclase by O'Donnell, V B, Taylor, K B, Parthasarathy, S, Kühn, H, Koesling, D, Friebe, A, Bloodsworth, A, Darley-Usmar, V M, Freeman, B A

“…Analysis of purified soybean and rabbit reticulocyte 15-lipoxygenase (15-LOX) and PA317 cells transfected with human 15-LOX revealed a rapid rate of…”
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Nitration of unsaturated fatty acids by nitric oxide-derived reactive species by O'Donnell, V B, Eiserich, J P, Bloodsworth, A, Chumley, P H, Kirk, M, Barnes, S, Darley-Usmar, V M, Freeman, B A

“…Reactions of linoleate (and presumably other unsaturated fatty acids) with reactive nitrogen species that form in biological systems from secondary reactions…”
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