Search Results - "O'Donnell, Martin J."

Hypertension and Cognitive Impairment: A Review of Mechanisms and Key Concepts by Canavan, Michelle, O'Donnell, Martin J

“…Cognitive impairment, and dementia, are major contributors to global burden of death and disability, with projected increases in prevalence in all regions of…”
Get full text

Embolic strokes of undetermined source: the case for a new clinical construct by Hart, Robert G, Dr Prof, Diener, Hans-Christoph, Prof, Coutts, Shelagh B, MD, Easton, J Donald, Prof, Granger, Christopher B, Prof, O'Donnell, Martin J, PhD, Sacco, Ralph L, Prof, Connolly, Stuart J, Prof

“…Summary Cryptogenic (of unknown cause) ischaemic strokes are now thought to comprise about 25% of all ischaemic strokes. Advances in imaging techniques and…”
Get full text

Methotrexate and Lung Disease in Rheumatoid Arthritis: A Meta‐Analysis of Randomized Controlled Trials by Conway, Richard, Low, Candice, Coughlan, Robert J., O'Donnell, Martin J., Carey, John J.

“…Objective Methotrexate has shown efficacy for the treatment of several diseases, especially rheumatoid arthritis (RA). Methotrexate has also been implicated as…”
Get full text

Measuring sodium intake: research and clinical applications by Judge, Conor, Narula, Sukrit, Mente, Andrew, Smyth, Andrew, Yusuf, Salim, O’Donnell, Martin J.

“…Although most current guidelines recommend a daily sodium intake of less than 2.3 g/day, most people do not have a reliable estimate of their usual sodium…”
Get full text

Fine Particulate Air Pollution (PM2.5) and the Risk of Acute Ischemic Stroke by O'Donnell, Martin J., Fang, Jiming, Mittleman, Murray A., Kapral, Moira K., Wellenius, Gregory A.

“…Background: Short-term changes in levels of fine ambient particulate matter (PM 2.5 ) may increase the risk of acute ischemic stroke; however, results from…”
Get full text

Urinary Sodium and Potassium Excretion and Risk of Cardiovascular Events by O'Donnell, Martin J, Yusuf, Salim, Mente, Andrew, Gao, Peggy, Mann, Johannes F, Teo, Koon, McQueen, Matthew, Sleight, Peter, Sharma, Arya M, Dans, Antonio, Probstfield, Jeffrey, Schmieder, Roland E

“…CONTEXT The precise relationship between sodium and potassium intake and cardiovascular (CV) risk remains uncertain, especially in patients with CV disease…”
Get full text

The impact of hospital presentation time on stroke outcomes: A nationally representative Irish cohort study by Loughlin, Elaine, Gabr, Ahmed, Galvin, Rose, McCormack, Joan, Brych, Olga, O'Donnell, Martin J, Collins, Rónán, Thornton, John, Harbison, Joseph, O'Connor, Margaret

“…There is conflicting evidence regarding the outcomes of acute stroke patients who present to hospital within normal working hours ('in-hours') compared with…”
Get full text

Antithrombotic and thrombolytic therapy for ischemic stroke: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines by Lansberg, Maarten G, O'Donnell, Martin J, Khatri, Pooja, Lang, Eddy S, Nguyen-Huynh, Mai N, Schwartz, Neil E, Sonnenberg, Frank A, Schulman, Sam, Vandvik, Per Olav, Spencer, Frederick A, Alonso-Coello, Pablo, Guyatt, Gordon H, Akl, Elie A

“…This article provides recommendations on the use of antithrombotic therapy in patients with stroke or transient ischemic attack (TIA). We generated treatment…”
Get full text

Leflunomide Use and Risk of Lung Disease in Rheumatoid Arthritis: A Systematic Literature Review and Metaanalysis of Randomized Controlled Trials by Conway, Richard, Low, Candice, Coughlan, Robert J, O'Donnell, Martin J, Carey, John J

“…To evaluate the relative risk (RR) of pulmonary disease among patients with rheumatoid arthritis (RA) treated with leflunomide (LEF). We searched PubMed,…”
Get full text

Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study by O'Donnell, Martin J, Dr, Xavier, Denis, Prof, Liu, Lisheng, Prof, Zhang, Hongye, Prof, Chin, Siu Lim, Rao-Melacini, Purnima, MSc, Rangarajan, Sumathy, MSc, Islam, Shofiqul, MSc, Pais, Prem, Prof, McQueen, Matthew J, Prof, Mondo, Charles, MD, Damasceno, Albertino, Prof, Lopez-Jaramillo, Patricio, Prof, Hankey, Graeme J, Prof, Dans, Antonio L, Prof, Yusoff, Khalid, Prof, Truelsen, Thomas, DMSc, Diener, Hans-Christoph, Prof, Sacco, Ralph L, Prof, Ryglewicz, Danuta, Prof, Czlonkowska, Anna, Prof, Weimar, Christian, Prof, Wang, Xingyu, Prof, Yusuf, Salim, Prof

“…Summary Background The contribution of various risk factors to the burden of stroke worldwide is unknown, particularly in countries of low and middle income…”
Get full text

The relationship between estimated sodium and potassium excretion and subsequent renal outcomes by Smyth, Andrew, Dunkler, Daniela, Gao, Peggy, Teo, Koon K, Yusuf, Salim, O'Donnell, Martin J, Mann, Johannes F E, Clase, Catherine M

“…Patients are often advised to reduce sodium and potassium intake, but supporting evidence is limited. To help provide such evidence we estimated 24 h urinary…”
Get more information

Risk of liver injury among methotrexate users: A meta-analysis of randomised controlled trials by Conway, Richard, MB, Low, Candice, MB, Coughlan, Robert J., MD, O’Donnell, Martin J., PhD, Carey, John J., MS

“…Abstract Objective Methotrexate is an effective treatment for a variety of inflammatory diseases. Robust evidence on the risk of serious liver injury is…”
Get full text

Sleep to Lower Elevated Blood Pressure: A Randomized Controlled Trial (SLEPT) by McGrath, Emer R, Espie, Colin A, Power, Alice, Murphy, Andrew W, Newell, John, Kelly, Caroline, Duffy, Niamh, Gunning, Patricia, Gibson, Irene, Bostock, Sophie, O'Donnell, Martin J

“…Impaired sleep quality is common and associated with an increased risk of cardiovascular disease (CVD), thought to be mediated through adverse effects on…”
Get full text

Association of Oral Anticoagulation With Stroke in Atrial Fibrillation or Heart Failure: A Comparative Meta-Analysis by Reddin, Catriona, Judge, Conor, Loughlin, Elaine, Murphy, Robert, Costello, Maria, Alvarez, Alberto, Ferguson, John, Smyth, Andrew, Canavan, Michelle, O’Donnell, Martin J.

“…Atrial fibrillation and heart failure with reduced ejection fraction (HFrEF) are common sources of cardioembolism. While oral anticoagulation is strongly…”
Get full text

Association of atrial fibrillation with mortality and disability after ischemic stroke by McGrath, Emer R., Kapral, Moira K., Fang, Jiming, Eikelboom, John W., O’Conghaile, Aengus, Canavan, Michelle, O’Donnell, Martin J.

“…OBJECTIVE:We determined whether patient characteristics (age, sex, comorbidities), stroke severity, and quality of care explained a proportion of the…”
Get full text

Sodium Intake and Renal Outcomes: A Systematic Review by Smyth, Andrew, O'Donnell, Martin J., Yusuf, Salim, Clase, Catherine M., Teo, Koon K., Canavan, Michelle, Reddan, Donal N., Mann, Johannes F. E.

“…BACKGROUND Sodium intake is an important determinant of blood pressure; therefore, reduction of intake may be an attractive population-based target for chronic…”
Get full text

How Robust Is the Evidence for Recommending Very Low Salt Intake in Entire Populations? by Mente, Andrew, PhD, O’Donnell, Martin J., MD, PhD, Yusuf, Salim, DPhil

“…The very low mean sodium intake (<1 g/day) reported in some of these primitive societies is often cited as evidence to support the safety of very low sodium…”
Get full text

Chronic Pain Syndromes After Ischemic Stroke PRoFESS Trial by O'DONNELL, Martin J, DIENER, Hans-Christoph, SACCO, Ralph L, PANJU, Akbar A, VINISKO, Richard, YUSUF, Salim

“…Chronic pain syndromes are reported to be common after stroke, but most previous epidemiological studies have generally included small cohorts of patients with…”
Get full text

Measuring Sodium Intake in Populations: Simple Is Best? by Mente, Andrew, O’Donnell, Martin J., Yusuf, Salim

Get full text

Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis by Raman, Kripa, O'Donnell, Martin J, Czlonkowska, Anna, Duarte, Yan Carlos, Lopez-Jaramillo, Patricio, Peñaherrera, Ernesto, Sharma, Mike, Shoamanesh, Ashkan, Skowronska, Marta, Yusuf, Salim, Paré, Guillaume

“…A limitation when making early decisions on stroke management is the lack of rapid diagnostic and prognostic testing. Our study sought to identify peripheral…”
Get full text