Search Results - "O'Donnell, Janis"

Innate immune responses to paraquat exposure in a Drosophila model of Parkinson’s disease by Maitra, Urmila, Scaglione, Michael N., Chtarbanova, Stanislava, O’Donnell, Janis M.

“…Parkinson’s disease (PD) is a progressive, neurodegenerative movement disorder characterized by the loss of dopaminergic (DA) neurons. Limited understanding of…”
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The Glycolytic Enzyme, GPI, Is a Functionally Conserved Modifier of Dopaminergic Neurodegeneration in Parkinson’s Models by Knight, Adam L., Yan, Xiaohui, Hamamichi, Shusei, Ajjuri, Rami R., Mazzulli, Joseph R., Zhang, Mike W., Daigle, J. Gavin, Zhang, Siyuan, Borom, Akeem R., Roberts, Lindsay R., Lee, S. Kyle, DeLeon, Susan M., Viollet-Djelassi, Coralie, Krainc, Dimitri, O’Donnell, Janis M., Caldwell, Kim A., Caldwell, Guy A.

“…Neurodegenerative diseases represent an increasing burden in our aging society, yet the underlying metabolic factors influencing onset and progression remain…”
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Modulation of social space by dopamine in Drosophila melanogaster, but no effect on the avoidance of the Drosophila stress odorant by Fernandez, Robert W., Akinleye, Adesanya A., Nurilov, Marat, Feliciano, Omar, Lollar, Matthew, Aijuri, Rami R., O'Donnell, Janis M., Simon, Anne F.

“…Appropriate response to others is necessary for social interactions. Yet little is known about how neurotransmitters regulate attractive and repulsive social…”
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Interaction of Genetic and Environmental Factors in a Drosophila Parkinsonism Model by Chaudhuri, Anathbandhu, Bowling, Kevin, Funderburk, Christopher, Lawal, Hakeem, Inamdar, Arati, Wang, Zhe, O'Donnell, Janis M

“…Catastrophic loss of dopaminergic neurons is a hallmark of Parkinson's disease. Despite the recent identification of genes associated with familial…”
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Disruption of dopamine homeostasis has sexually dimorphic effects on senescence characteristics of Drosophila melanogaster by Bednářová, Andrea, Hanna, Marley E., Rakshit, Kuntol, O'Donnell, Janis M., Krishnan, Natraj, Galizia, C. Giovanni

“…The neurotransmitter dopamine (DA) is known to be involved in a multitude of physiological processes. We investigated sexually dimorphic effects of disruptions…”
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The Drosophila Gene Sulfateless Modulates Autism-Like Behaviors by Hope, Kevin A, Flatten, Daniel, Cavitch, Peter, May, Ben, Sutcliffe, James S, O'Donnell, Janis, Reiter, Lawrence T

“…Major challenges to identifying genes that contribute to autism spectrum disorder (ASD) risk include the availability of large ASD cohorts, the contribution of…”
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Dtorsin, the Drosophila ortholog of the early-onset dystonia TOR1A (DYT1), plays a novel role in dopamine metabolism by Wakabayashi-Ito, Noriko, Doherty, Olugbenga M, Moriyama, Hideaki, Breakefield, Xandra O, Gusella, James F, O'Donnell, Janis M, Ito, Naoto

“…Dystonia represents the third most common movement disorder in humans. At least 15 genetic loci (DYT1-15) have been identified and some of these genes have…”
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The Protective Effect of Minocycline in a Paraquat-Induced Parkinson's Disease Model in Drosophila is Modified in Altered Genetic Backgrounds by Inamdar, Arati A., O’Donnell, Janis, Chaudhuri, Anathbandhu

“…Epidemiological studies link the herbicide paraquat to increased incidence of Parkinson's disease (PD). We previously reported that Drosophila exposed to…”
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Novel whole-tissue quantitative assay of nitric oxide levels in Drosophila neuroinflammatory response by Ajjuri, Rami R, O'Donnell, Janis M

“…Neuroinflammation is a complex innate immune response vital to the healthy function of the central nervous system (CNS). Under normal conditions, an intricate…”
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Drosophila Ube3a regulates monoamine synthesis by increasing GTP cyclohydrolase I activity via a non-ubiquitin ligase mechanism by Ferdousy, Faiza, Bodeen, William, Summers, Kyle, Doherty, Olugbenga, Wright, O'Neil, Elsisi, Nahed, Hilliard, George, O'Donnell, Janis M, Reiter, Lawrence T

“…Abstract The underlying defects in Angelman syndrome (AS) and autism spectrum disorder (ASD) may be in part due to basic defects in synaptic plasticity and…”
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Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis by Bowling, Kevin M, Huang, Zhinong, Xu, Dong, Ferdousy, Faiza, Funderburk, Christopher D, Karnik, Nirmala, Neckameyer, Wendi, O'Donnell, Janis M

“…The signaling functions of dopamine require a finely tuned regulatory network for rapid induction and suppression of output. A key target of regulation is the…”
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Drosophila dopamine synthesis pathway genes regulate tracheal morphogenesis by Hsouna, Anita, Lawal, Hakeem O., Izevbaye, Iyare, Hsu, Tien, O'Donnell, Janis M.

“…While studying the developmental functions of the Drosophila dopamine synthesis pathway genes, we noted interesting and unexpected mutant phenotypes in the…”
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Mutant human torsinA, responsible for early-onset dystonia, dominantly suppresses GTPCH expression, dopamine levels and locomotion in Drosophila melanogaster by Wakabayashi-Ito, Noriko, Ajjuri, Rami R, Henderson, Benjamin W, Doherty, Olugbenga M, Breakefield, Xandra O, O'Donnell, Janis M, Ito, Naoto

“…Dystonia represents the third most common movement disorder in humans with over 20 genetic loci identified. TOR1A (DYT1), the gene responsible for the most…”
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Cytotoxicity of Plasticizers and Ionic Liquids Using Drosophila melanogaster S2 Cell Culture by Rahman, M., O'Donnell, J. M., Brazel, C. S.

“…One successfully demonstrated application of ionic liquids (ILs) is to produce flexible polymeric materials, i.e., as plasticizers. However, the use of ILs as…”
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Nutritional supplement chromium picolinate generates chromosomal aberrations and impedes progeny development in Drosophila melanogaster by Stallings, Dontarie M., Hepburn, Dion D.D., Hannah, Meredith, Vincent, John B., O’Donnell, Janis

“…Chromium picolinate, [Cr(pic) 3], is a popular nutritional supplement found in a variety of consumer products. Despite its popularity, safety concerns over its…”
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Perturbations in dopamine synthesis lead to discrete physiological effects and impact oxidative stress response in Drosophila by Hanna, Marley E., Bednářová, Andrea, Rakshit, Kuntol, Chaudhuri, Anathbandhu, O’Donnell, Janis M., Krishnan, Natraj

“…•Decreased synthesis of dopamine (DA) results in shortened lifespan in Drosophila.•Circadian locomotor activity rhythm is unaffected by DA levels.•Decreased DA…”
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Catecholamines up (Catsup) protein of Drosophila melanogaster functions as a negative regulator of tyrosine hydroxylase activity by Stathakis, D.G. i, Burton, D.Y, McIvor, W.E, Krishnakumar, S, Wright, T.R.F, O'Donnell, J.M

“…We report the genetic, phenotypic, and biochemical analyses of Catecholamines up (Catsup), a gene that encodes a negative regulator of tyrosine hydroxylase…”
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A typical N-terminal Extensions Confer Novel Regulatory Properties on GTP Cyclohydrolase Isoforms in Drosophila melanogaster by Funderburk, Christopher D., Bowling, Kevin M., Xu, Dong, Huang, Zhinong, O'Donnell, Janis M.

“…The cofactor tetrahydrobiopterin plays critical roles in the modulation of the signaling molecules dopamine, serotonin, and nitric oxide. Deficits in cofactor…”
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Catecholamines up integrates dopamine synthesis and synaptic trafficking by Wang, Zhe, Ferdousy, Faiza, Lawal, Hakeem, Huang, Zhinong, Daigle, J. Gavin, Izevbaye, Iyare, Doherty, Olugbenga, Thomas, Jerrad, Stathakis, Dean G, O’Donnell, Janis M.

“…J. Neurochem. (2011) 10.1111/j.1471‐4159.2011.07517.x The highly reactive nature of dopamine renders dopaminergic neurons vulnerable to oxidative damage. We…”
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Protein Expression Profiling of the Fragile X Mutant Brain Reveals Up-regulation of Monoamine Synthesis by Zhang, Yong Q., Friedman, David B., Wang, Zhe, Woodruff, Elvin, Pan, Luyuan, O'Donnell, Janis, Broadie, Kendal

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