Search Results - "O'Donnell, JM"

Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4) by O'Donnell, James M, Zhang, Han-Ting

“…Despite initial promise, the development of type 4 phosphodiesterase (PDE4) inhibitors as antidepressants has not advanced significantly. This is due to an…”
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Inhibition of the Phosphodiesterase 4 (PDE4) Enzyme Reverses Memory Deficits Produced by Infusion of the MEK Inhibitor U0126 into the CA1 Subregion of the Rat Hippocampus by Zhang, Han-Ting, Zhao, Yu, Huang, Ying, Dorairaj, Nandakumar R, Chandler, L Judson, O'Donnell, James M

“…Cyclic AMP-specific phosphodiesterase 4 (PDE4), which is an integral component of NMDA receptor-mediated cAMP signaling, is involved in the mediation of memory…”
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Antidepressant-like Profile and Reduced Sensitivity to Rolipram in Mice Deficient in the PDE4D Phosphodiesterase Enzyme by Zhang, Han-Ting, Huang, Ying, Jin, S.-L.Catherine, Frith, Sandra A, Suvarna, Neesha, Conti, Marco, O'Donnell, James M

“…Pharmacological inhibition of type 4 cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase (PDE4) produces antidepressant-like effects in animals;…”
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Background identification and suppression for the measurement of (n,γ) reactions with the DANCE array at LANSCE by Reifarth, R., Bredeweg, T.A., Alpizar-Vicente, A., Browne, J.C., Esch, E.-I., Greife, U., Haight, R.C., Hatarik, R., Kronenberg, A., O'Donnell, J.M., Rundberg, R.S., Ullmann, J.L., Vieira, D.J., Wilhelmy, J.B., Wouters, J.M.

“…In the commissioning phase of the DANCE project (Detector for Advanced Neutron Capture Experiments) measurements have been performed with special emphasis on…”
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Effects of rolipram on scopolamine-induced impairment of working and reference memory in the radial-arm maze tests in rats by ZHANG, H.-T, O'DONNELL, J. M

“…Rolipram, a selective inhibitor of cyclic AMP-specific phosphodiesterase (PDE4), has been shown to enhance scopolamine-induced impairment of working memory…”
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Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats by ZHANG, Han-Ting, YING HUANG, SUVARNA, Neesha U, DENG, Chengjun, CRISSMAN, Alicia M, HOPPER, Allen T, DE VIVO, Michael, ROSE, Gregory M, O'DONNELL, James M

“…Inhibition of cyclic AMP (cAMP)-specific phosphodiesterase (PDE4) enhances memory in rodents. MEM1018 and MEM1091 are newly developed PDE4 inhibitors that had…”
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Hydrolysis of N-methyl-D-aspartate receptor-stimulated cAMP and cGMP by PDE4 and PDE2 phosphodiesterases in primary neuronal cultures of rat cerebral cortex and hippocampus by Suvarna, Neesha U, O'Donnell, James M

“…Stimulation of N-methyl-D-aspartate (NMDA) receptors on neurons activates both cAMP and cGMP signaling pathways. Experiments were carried out to determine…”
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Antidepressant effects assessed using behavior maintained under a differential-reinforcement-of-low-rate (DRL) operant schedule by O'Donnell, James M., Marek, Gerard J., Seiden, Lewis S.

“…Behavior maintained under a differential-reinforcement-of-low-rate (DRL) 72-s operant schedule, which reinforces responses with interresponse times greater…”
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Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats by ZHANG, Han-Ting, YU ZHAO, YING HUANG, CHENGJUN DENG, HOPPER, Allen T, DE VIVO, Michael, ROSE, Gregory M, O'DONNELL, James M

“…Phosphodiesterase-4 (PDE4) has two conformation states based on rolipram binding, the high-affinity rolipram binding state (HARBS) and the low-affinity…”
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Accelerated triacylglycerol turnover kinetics in hearts of diabetic rats include evidence for compartmented lipid storage by O'Donnell, J Michael, Zampino, Manuela, Alpert, Nathaniel M, Fasano, Matthew J, Geenen, David L, Lewandowski, E Douglas

“…Triacylglycerol (TAG) storage and turnover rates in the intact, beating rat heart were determined for the first time using dynamic mode (13)C- NMR spectroscopy…”
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Neutron Multiplicity in the Fission of U 238 and U 235 with Neutrons up to 200 MeV by Ethvignot, T., Devlin, M., Duarte, H., Granier, T., Haight, R. C., Morillon, B., Nelson, R. O., O'Donnell, J. M., Rochman, D.

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Limited transfer of cytosolic NADH into mitochondria at high cardiac workload by O'Donnell, J Michael, Kudej, Raymond K, LaNoue, Kathyrn F, Vatner, Stephen F, Lewandowski, E Douglas

“…Glycolysis supplements energy synthesis at high cardiac workloads, producing not only ATP but also cytosolic NADH and pyruvate for oxidative ATP synthesis…”
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Acquisition-analysis system for the DANCE (detector for advanced neutron capture experiments) BaF2 gamma-ray calorimeter by Wouters, J.M, Vicente, A.A, Bredeweg, T.A, Esch, E, Haight, R.C, Hatarik, R, O'Donnell, J.M, Reifarth, R, Rundberg, R.S, Schwantes, J.M, Sheets, S.A, Ullmann, J.L, Vieira, D.J, Wilhelmy, J.B

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Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism by ZHANG, H.-T, CRISSMAN, A. M, DORAIRAJ, N. R, CHANDLER, L. J, O'DONNELL, J. M

“…Rolipram, a selective inhibitor of type 4 cyclic AMP phosphodiesterase (PDE4), completely reversed the amnesic effects of MK-801 on working and reference…”
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Fathers in Child Welfare: Caseworkers' Perspectives by O'Donnell, John M., Johnson, Waldo E., D'Aunno, Lisa Easley, Thornton, Helen L.

“…Five focus groups substantially agreeed about the lack of paternal participation in child welfare services and the reasons for low paternal involvement. The…”
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A study of VitalView™ for behavioural and physiological monitoring in laboratory rats by Harkin, Andrew, O'Donnell, James M., Kelly, John P.

“…We describe the use of a commercially available telemetry and data acquisition system to record heart rate, body temperature and activity of freely behaving…”
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Efficient, cardiac-specific adenoviral gene transfer in rat heart by isolated retrograde perfusion in vivo by O'DONNELL, J. Michael, LEWANDOWSKI, E. Douglas

“…While a number of virus-based delivery schemes have been developed for myocardial gene transfer, no technique has proven capable of modifying a majority of…”
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Interaction between the antidepressant-like behavioral effects of beta adrenergic agonists and the cyclic AMP PDE inhibitor rolipram in rats by ZHANG, Han-Ting, YING HUANG, MISHLER, Kathleen, ROERIG, Sandra C, O'DONNELL, James M

“…Type 4 phosphodiesterase (PDE4) is critical for hydrolysis of cAMP formed by stimulation of beta adrenergic receptors. However, it is not known if PDE4 is…”
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Effects of Repeated Antidepressant Treatment on Type 4A Phosphodiesterase (PDE4A) in Rat Brain by Ye, Ying, Jackson, Keasha, O'Donnell, James M.

“…In a previous study, an up‐regulation of rolipram‐sensitive, low‐Km, cyclic AMP phosphodiesterase (PDE4) subtype PDE4A in rat cerebral cortex following…”
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Antidepressant-induced increase in high-affinity rolipram binding sites in rat brain: dependence on noradrenergic and serotonergic function by Zhao, Yu, Zhang, Han-Ting, O'Donnell, James M

“…The effects of antidepressant treatment on the high- and low-affinity rolipram binding sites on type 4 phosphodiesterase (PDE4) were determined; previous work…”
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