Search Results - "O'Donnell, Charles"

Differentiated human stem cells resemble fetal, not adult, β cells by Hrvatin, Siniša, O'Donnell, Charles W., Deng, Francis, Millman, Jeffrey R., Pagliuca, Felicia Walton, Dilorio, Philip, Rezania, Alireza, Gifford, David K., Melton, Douglas A.

“…Human pluripotent stem cells (hPSCs) have the potential to generate any human cell type, and one widely recognized goal is to make pancreatic β cells. To this…”
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Opposing Effects of Glutamine and Asparagine Govern Prion Formation by Intrinsically Disordered Proteins by Halfmann, Randal, Alberti, Simon, Krishnan, Rajaraman, Lyle, Nicholas, O'Donnell, Charles W., King, Oliver D., Berger, Bonnie, Pappu, Rohit V., Lindquist, Susan

“…Sequences rich in glutamine (Q) and asparagine (N) residues often fail to fold at the monomer level. This, coupled to their unusual hydrogen-bonding abilities,…”
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Targeted transcriptional downregulation of MYC using epigenomic controllers demonstrates antitumor activity in hepatocellular carcinoma models by Senapedis, William, Gallagher, Kayleigh M., Figueroa, Elmer, Farelli, Jeremiah D., Lyng, Robert, Hodgson, J. Graeme, O’Donnell, Charles W., Newman, Joseph V., Pacaro, Madison, Siecinski, Stephen K., Chen, Justin, McCauley, Thomas G.

“…Dysregulation of master regulator c - MYC (MYC) plays a central role in hepatocellular carcinoma (HCC) and other cancers but remains an elusive target for…”
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MARIS: method for analyzing RNA following intracellular sorting by Hrvatin, Siniša, Deng, Francis, O'Donnell, Charles W, Gifford, David K, Melton, Douglas A

“…Transcriptional profiling is a key technique in the study of cell biology that is limited by the availability of reagents to uniquely identify specific cell…”
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Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape by Sherwood, Richard I, Hashimoto, Tatsunori, O'Donnell, Charles W, Lewis, Sophia, Barkal, Amira A, van Hoff, John Peter, Karun, Vivek, Jaakkola, Tommi, Gifford, David K

“…A new algorithm learns features of chromatin profiles left by transcription factors, shedding light on when DNA sequence motifs are bound. We describe protein…”
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A distant trophoblast-specific enhancer controls HLA-G expression at the maternal–fetal interface by Ferreira, Leonardo M. R., Meissner, Torsten B., Mikkelsen, Tarjei S., Mallard, William, O’Donnell, Charles W., Tilburgs, Tamara, Gomes, Hannah A. B., Camahort, Raymond, Sherwood, Richard I., Gifford, David K., Rinn, John L., Cowan, Chad A., Strominger, Jack L.

“…HLA-G, a nonclassical HLA molecule uniquely expressed in the placenta, is a central component of fetus-induced immune tolerance during pregnancy. The…”
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A global sampling approach to designing and reengineering RNA secondary structures by Levin, Alex, Lis, Mieszko, Ponty, Yann, O'Donnell, Charles W, Devadas, Srinivas, Berger, Bonnie, Waldispühl, Jérôme

“…The development of algorithms for designing artificial RNA sequences that fold into specific secondary structures has many potential biomedical and synthetic…”
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Enhancing Repo Market Transparency: The EU Securities Financing Transactions Regulation by Bassi, Claudio, Grill, Michael, Hermes, Felix, Mirza, Harun, O’Donnell, Charles, Wedow, Michael

“…The introduction of the Securities Financing Transactions Regulation into EU law provides a unique opportunity to obtain an in-depth understanding of repo…”
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A method for probing the mutational landscape of amyloid structure by O'Donnell, Charles W., Waldispühl, Jérôme, Lis, Mieszko, Halfmann, Randal, Devadas, Srinivas, Lindquist, Susan, Berger, Bonnie

“…Motivation: Proteins of all kinds can self-assemble into highly ordered β-sheet aggregates known as amyloid fibrils, important both biologically and…”
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Design and Optimization of Pyrazinecarboxamide-Based Inhibitors of Diacylglycerol Acyltransferase 1 (DGAT1) Leading to a Clinical Candidate Dimethylpyrazinecarboxamide Phenylcyclohexylacetic Acid (AZD7687) by Barlind, Jonas G., Bauer, Udo A., Birch, Alan M., Birtles, Susan, Buckett, Linda K., Butlin, Roger J., Davies, Robert D. M., Eriksson, Jan W., Hammond, Clare D., Hovland, Ragnar, Johannesson, Petra, Johansson, Magnus J., Kemmitt, Paul D., Lindmark, Bo T., Morentin Gutierrez, Pablo, Noeske, Tobias A., Nordin, Andreas, O’Donnell, Charles J., Petersson, Annika U., Redzic, Alma, Turnbull, Andrew V., Vinblad, Johanna

“…A new series of pyrazinecarboxamide DGAT1 inhibitors was designed to address the need for a candidate drug with good potency, selectivity, and physical and…”
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Feasibility, Acceptability, and Adoption of an Inpatient Tobacco Treatment Service at a Safety-Net Hospital: A Mixed-Methods Study by Seth, Bhavna, Herbst, Nicole, Oleinik, Katia, Clark, Kristopher, Helm, Eric D, O'Donnell, Charles, Fitzgerald, Carmel, Wong, Carolina, Wiener, Renda Soylemez, Kathuria, Hasmeena

“…Hospitalization is an opportunity to engage smokers who may not seek tobacco treatment. Our safety-net hospital developed and implemented an inpatient…”
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STITCHER: Dynamic assembly of likely amyloid and prion β-structures from secondary structure predictions by Bryan Jr, Allen W., O'Donnell, Charles W., Menke, Matthew, Cowen, Lenore J., Lindquist, Susan, Berger, Bonnie

“…The supersecondary structure of amyloids and prions, proteins of intense clinical and biological interest, are difficult to determine by standard experimental…”
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Design and Implementation of the AEGIS Single-Chip Secure Processor Using Physical Random Functions by Suh, G Edward, O'Donnell, Charles W, Sachdev, Ishan, Devadas, Srinivas

“…Secure processors enable new applications by ensuring private and authentic program execution even in the face of physical attack. In this paper we present the…”
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A Financial Incentives Program to Promote Smoking Cessation Among Recently Hospitalized Individuals: Feasibility and Acceptability Study by Shusterman, Sara, Villarreal-Calderon, Rodolfo, Gunawan, Adrian, Gallardo Foreman, Alexis, O'Donnell, Charles, Wakeman, Cornelia, Javeed, Hadi, Keteyian, Jacob, Howard, Jinesa, Bulekova, Katia, de Silva, Shalen, Campbell, Trevor, Lasser, Karen, Kathuria, Hasmeena

“…Hospitalization is an opportunity to engage underserved individuals in tobacco treatment who may not otherwise have access to it. Tobacco treatment…”
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Modeling ensembles of transmembrane β-barrel proteins by Waldispühl, Jérôme, O'Donnell, Charles W., Devadas, Srinivas, Clote, Peter, Berger, Bonnie

“…Transmembrane β‐barrel (TMB) proteins are embedded in the outer membrane of Gram‐negative bacteria, mitochondria, and chloroplasts. Despite their importance,…”
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Experimental and mathematical analysis of in vitro Pitavastatin hepatic uptake across species by Grandjean, Thomas R. B., Chappell, Mike J., Lench, Alex M., Yates, James W. T., O'Donnell, Charles J.

“…Abstract 1. To investigate the non-linear kinetics of in vitro hepatocyte uptake across species, the OATP substrate Pitavastatin was used as a probe. 2…”
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Simultaneous alignment and folding of protein sequences by Waldispühl, Jérôme, O'Donnell, Charles W, Will, Sebastian, Devadas, Srinivas, Backofen, Rolf, Berger, Bonnie

“…Accurate comparative analysis tools for low-homology proteins remains a difficult challenge in computational biology, especially sequence alignment and…”
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Drugging the epigenome in the age of precision medicine by Feehley, Taylor, O'Donnell, Charles W, Mendlein, John, Karande, Mahesh, McCauley, Thomas

“…Modulating the epigenome has long been considered a potential opportunity for therapeutic intervention in numerous disease areas with several approved…”
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3-Chlorotyrosine in sputum of COPD patients: relationship with airway inflammation by O'Donnell, Charles, Newbold, Paul, White, Peter, Thong, Bob, Stone, Helen, Stockley, Robert A

“…The airways of patients with chronic obstructive pulmonary disease (COPD) are associated with increased numbers of inflammatory cells, in particular…”
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The development of a cocktail CYP2B6, CYP2C8, and CYP3A5 inhibition assay and a preliminary assessment of utility in a drug discovery setting by O'DONNELL, Charles J, GRIME, Ken, COURTNEY, Paul, SLEE, Dean, RILEY, Robert J

“…Tools for studying the roles of CYP2B6, CYP2C8, and CYP3A5 in drug metabolism have recently become available. The level of interest in these enzymes has been…”
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