Search Results - "O'Dea, Shirley"

Regulation of epithelial to mesenchymal transition by bone morphogenetic proteins by McCormack, Natasha, O'Dea, Shirley

“…Epithelial to mesenchymal transition (EMT) is a process in which fully differentiated epithelial cells lose many of their epithelial characteristics and adopt…”
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Vector-free intracellular delivery by reversible permeabilization by O'Dea, Shirley, Annibaldi, Valeria, Gallagher, Louise, Mulholland, Joanne, Molloy, Emer L, Breen, Conor J, Gilbert, Jennifer L, Martin, Darren S, Maguire, Michael, Curry, Fitz-Roy

“…Despite advances in intracellular delivery technologies, efficient methods are still required that are vector-free, can address a wide range of cargo types and…”
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SMAD Signaling in the Airways of Healthy Rhesus Macaques versus Rhesus Macaques with Asthma Highlights a Relationship Between Inflammation and Bone Morphogenetic Proteins by Lynn, Therese M, Molloy, Emer L, Masterson, Joanne C, Glynn, Senan F, Costello, Richard W, Avdalovic, Mark V, Schelegle, Edward S, Miller, Lisa A, Hyde, Dallas M, O'Dea, Shirley

“…Bone morphogenetic protein (BMP) signaling is important for correct lung morphogenesis, and there is evidence of BMP signaling reactivation in lung diseases…”
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Anatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine by Judge, Eoin P, Hughes, J M Lynne, Egan, Jim J, Maguire, Michael, Molloy, Emer L, O'Dea, Shirley

“…The porcine model has contributed significantly to biomedical research over many decades. The similar size and anatomy of pig and human organs make this model…”
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A Novel Methodology for Bio-electrospraying Mesenchymal Stem Cells that Maintains Differentiation, Immunomodulatory and Pro-reparative Functions by McCrea, Zita, Arnanthigo, Yonsuang, Cryan, Sally-Ann, O’Dea, Shirley

“…Mesenchymal stem cells (MSCs) are an important cell source for tissue engineering (TE) and cell therapies for several reasons including ease of isolation from…”
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Reducing the false positive rate in the non-parametric analysis of molecular coevolution by Codoñer, Francisco M, O'Dea, Shirley, Fares, Mario A

“…The strength of selective constraints operating on amino acid sites of proteins has a multifactorial nature. In fact, amino acid sites within proteins coevolve…”
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Bone morphogenetic proteins enhance an epithelial-mesenchymal transition in normal airway epithelial cells during restitution of a disrupted epithelium by McCormack, Natasha, Molloy, Emer L, O'Dea, Shirley

“…Mechanisms of airway repair are poorly understood. It has been proposed that, following injury, progenitor populations such as club cells (Clara) become…”
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IFN-γ stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro by Noone, Cariosa, Kihm, Anthony, English, Karen, O'Dea, Shirley, Mahon, Bernard P

“…Umbilical cord tissue represents a unique source of cells with potential for cell therapy applications for multiple diseases. Human umbilical tissue-derived…”
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Posttranslational truncation of E-cadherin and significance for tumour progression by Masterson, Joanne, O'Dea, Shirley

“…Stable intraepithelial adhesion complexes are essential for the maintenance of epithelial integrity. Alterations in these complexes are key events in the…”
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Delivery of nucleic acids to ex vivo porcine airways using electrospray by Riddell, Peter, Gilbert, Jennifer L., Molloy, Emer L., Finnegan, Shane, Egan, Jim J., O'Dea, Shirley

“…Aim of the Study: Nucleic acid-based therapies have the potential to provide clinically meaningful benefit across a wide spectrum of lung disease. However, in…”
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Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest by Armit, Christopher J, O'Dea, Shirley, Clarke, Alan R, Harrison, David J

“…The p53 oncosuppressor protein is a critical mediator of the response to injury in mammalian cells and is mutationally inactivated in the majority of lung…”
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The development of a tissue-engineered tracheobronchial epithelial model using a bilayered collagen-hyaluronate scaffold by O'Leary, Cian, Cavanagh, Brenton, Unger, Ronald E, Kirkpatrick, C. James, O'Dea, Shirley, O'Brien, Fergal J, Cryan, Sally-Ann

“…Abstract Today, chronic respiratory disease is one of the leading causes of mortality globally. Epithelial dysfunction can play a central role in its…”
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A novel non-viral delivery method that enables efficient engineering of primary human T cells for ex vivo cell therapy applications by Kavanagh, Heather, Dunne, Susan, Martin, Darren S., McFadden, Emily, Gallagher, Louise, Schwaber, Jessica, Leonard, Siobhán, O'Dea, Shirley

“…Next-generation immune cell therapy products will require complex modifications using engineering technologies that can maintain high levels of cell…”
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5-Bromo-2-deoxyuridine activates DNA damage signalling responses and induces a senescence-like phenotype in p16-null lung cancer cells by Masterson, Joanne C, OʼDea, Shirley

“…5-Bromo-2-deoxyuridine (BrdU) is a thymidine analogue that is incorporated into replicating DNA. Although originally designed as a chemotherapeutic agent,…”
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mRNA Delivery to T Cells with Retention of Cell Viability, Proliferation and Functionality Using a Novel Vector-Free Intracellular Delivery Method ‘Soluporation by O'Dea, Shirley, Darren, Martin, Kavanagh, Heather, Mulholland, Joanne, Dunne, Susan, Gallagher, Louise

“…Membrane-disruption-based methods that enable intracellular delivery of various cargo types for clinical applications have been proposed as attractive…”
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Efficient vector-free engineering of MSC with retention of cell viability and differentiation potential by Martin, Darren, Annibaldi, Valeria, Masterson, Joanne, Gallagher, Louise, O'Dea, Shirley

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LB50 - Efficient vector-free engineering of MSC with retention of cell viability and differentiation potential by Martin, Darren, Annibaldi, Valeria, Masterson, Joanne, Gallagher, Louise, O'Dea, Shirley

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Comparative evaluation of viral, nonviral and physical methods of gene delivery to normal and transformed lung epithelial cells by Gilbert, Jennifer L, Purcell, James, Strappe, Padraig, McCabe, Matthew, OʼBrien, Timothy, OʼDea, Shirley

“…Few studies have directly compared the efficiencies of gene delivery methods that target normal lung cells versus lung tumor cells. We report the first study…”
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Respiratory Tissue Engineering: Current Status and Opportunities for the Future by O'Leary, Cian, Gilbert, Jennifer L, O'Dea, Shirley, O'Brien, Fergal J, Cryan, Sally-Ann

“…Currently, lung disease and major airway trauma constitute a major global healthcare burden with limited treatment options. Airway diseases such as chronic…”
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Olfactomedin III expression contributes to anoikis-resistance in clonal variants of a human lung squamous carcinoma cell line by Keenan, Joanne, Joyce, Helena, Aherne, Sinead, O'Dea, Shirley, Doolan, Padraig, Lynch, Vincent, Clynes, Martin

“…Three clonal subpopulations of DLKP, a poorly differentiated squamous lung carcinoma cell line, display striking differences in ability to survive in…”
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