Search Results - "O'DONNELL, H"

Using high-resolution variant frequencies to empower clinical genome interpretation by Whiffin, Nicola, Minikel, Eric, Walsh, Roddy, O’Donnell-Luria, Anne H, Karczewski, Konrad, Ing, Alexander Y, Barton, Paul J R, Funke, Birgit, Cook, Stuart A, MacArthur, Daniel, Ware, James S

“…Purpose Whole-exome and whole-genome sequencing have transformed the discovery of genetic variants that cause human Mendelian disease, but discriminating…”
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Adjuvant atezolizumab versus observation in muscle-invasive urothelial carcinoma (IMvigor010): a multicentre, open-label, randomised, phase 3 trial by Bellmunt, Joaquim, Hussain, Maha, Gschwend, Jürgen E, Albers, Peter, Oudard, Stephane, Castellano, Daniel, Daneshmand, Siamak, Nishiyama, Hiroyuki, Majchrowicz, Martin, Degaonkar, Viraj, Shi, Yi, Mariathasan, Sanjeev, Grivas, Petros, Drakaki, Alexandra, O'Donnell, Peter H, Rosenberg, Jonathan E, Geynisman, Daniel M, Petrylak, Daniel P, Hoffman-Censits, Jean, Bedke, Jens, Kalebasty, Arash Rezazadeh, Zakharia, Yousef, van der Heijden, Michiel S, Sternberg, Cora N, Davarpanah, Nicole N, Powles, Thomas

“…Despite standard curative-intent treatment with neoadjuvant cisplatin-based chemotherapy, followed by radical surgery in eligible patients, muscle-invasive…”
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One Psychology Profession, Many Standards: A Narrative Review of Training, Licensing, and Practice Standards and Their Implications for International Mobility by Hosoda-Urban, Tamaki, Watanabe, Makiko, O'Donnell, Ellen H

“…This narrative review paper contrasts the professional prospects of psychologists in Japan and the U.S., discussing how divergent training, licensing, and…”
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Safety and activity of pembrolizumab in patients with locally advanced or metastatic urothelial cancer (KEYNOTE-012): a non-randomised, open-label, phase 1b study by Plimack, Elizabeth R, Dr, Bellmunt, Joaquim, MD, Gupta, Shilpa, MD, Berger, Raanan, MD, Chow, Laura Q M, MD, Juco, Jonathan, MD, Lunceford, Jared, PhD, Saraf, Sanatan, PhD, Perini, Rodolfo F, MD, O'Donnell, Peter H, MD

“…Summary Background PD-1 and its ligands are expressed in urothelial cancer, and findings have shown that inhibition of the PD-1 pathway has clinical benefit…”
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matchbox: An open‐source tool for patient matching via the Matchmaker Exchange by Arachchi, Harindra, Wojcik, Monica H, Weisburd, Benjamin, Jacobsen, Julius O. B., Valkanas, Elise, Baxter, Samantha, Byrne, Alicia B., O'Donnell‐Luria, Anne H., Haendel, Melissa, Smedley, Damian, MacArthur, Daniel G., Philippakis, Anthony A., Rehm, Heidi L.

“…Rare disease investigators constantly face challenges in identifying additional cases to build evidence for gene‐disease causality. The Matchmaker Exchange…”
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Unique bioinformatic approach and comprehensive reanalysis improve diagnostic yield of clinical exomes by Schmitz-Abe, Klaus, Li, Qifei, Rosen, Samantha M, Nori, Neeharika, Madden, Jill A, Genetti, Casie A, Wojcik, Monica H, Ponnaluri, Sadhana, Gubbels, Cynthia S, Picker, Jonathan D, O'Donnell-Luria, Anne H, Yu, Timothy W, Bodamer, Olaf, Brownstein, Catherine A, Beggs, Alan H, Agrawal, Pankaj B

“…Clinical exome sequencing (CES) is increasingly being utilized; however, a large proportion of patients remain undiagnosed, creating a need for a systematic…”
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Health Motivation in the Influencer Era: Analyzing Entertainment, Personal, and Social Media Role Models by O'Donnell, Nicole H, Erlichman, Sara, Nickerson, Christina G

“…This research explored how personal and entertainment role models motivate an individual's health goals, and how following a role model on social media affects…”
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What drives support for self-driving car technology in the United States? by Dixon, Graham, Hart, P. Sol, Clarke, Christopher, O'Donnell, Nicole H., Hmielowski, Jay

“…Recent advances in automotive technology have made fully automated self-driving cars technologically feasible. Despite offering many benefits such as increased…”
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BeTheMatch: Assessing How Testimonials on Reddit Promote the Importance of Donating Bone Marrow by O'Donnell, Nicole H., Guidry, Jeanine P. D.

“…This study explores how sharing testimonials on the social media network Reddit may encourage individuals to donate bone marrow. The theory of planned behavior…”
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Characterization of Prevalence and Health Consequences of Uniparental Disomy in Four Million Individuals from the General Population by Nakka, Priyanka, Pattillo Smith, Samuel, O’Donnell-Luria, Anne H., McManus, Kimberly F., Agee, Michelle, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Furlotte, Nicholas A., Hicks, Barry, Hinds, David A., Jewett, Ethan M., Jiang, Yunxuan, Lin, Keng-Han, McCreight, Jennifer C., Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McIntyre, Matthew H., Noblin, Elizabeth S., Northover, Carrie A.M., Pitts, Steven J., Poznik, G. David, Shelton, Janie F., Shringarpure, Suyash, Tian, Chao, Tung, Joyce Y., Vacic, Vladimir, Wang, Xin, Mountain, Joanna L., Ramachandran, Sohini, Sathirapongsasuti, J. Fah

“…Meiotic nondisjunction and resulting aneuploidy can lead to severe health consequences in humans. Aneuploidy rescue can restore euploidy but may result in…”
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Prenatal smoking and age at menarche: influence of the prenatal environment on the timing of puberty by Behie, A.M., O'Donnell, M.H.

“…STUDY QUESTION Do prenatal exposure to cigarette smoking and birthweight influence age at menarche (AAM) in a cohort of Australian girls? SUMMARY ANSWER We…”
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A scripting interface for GSAS‐II by O'Donnell, Jackson H., Von Dreele, Robert B., Chan, Maria K. Y., Toby, Brian H.

“…The GSAS‐II suite is a complete crystallographic analysis package for all types of X‐ray and neutron diffraction data, suited for fitting models ranging from…”
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Hyperconserved CpG domains underlie Polycomb-binding sites by Tanay, Amos, O'Donnell, Anne H, Damelin, Marc, Bestor, Timothy H

“…Comparative genomics of CpG dinucleotides, which are targets of DNA methyltransferases in vertebrate genomes, has been constrained by their evolutionary…”
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Pathogenic ASXL1 somatic variants in reference databases complicate germline variant interpretation for Bohring–Opitz Syndrome by Carlston, Colleen M., O'Donnell‐Luria, Anne H., Underhill, Hunter R., Cummings, Beryl B., Weisburd, Ben, Minikel, Eric V., Birnbaum, Daniel P., Tvrdik, Tatiana, MacArthur, Daniel G., Mao, Rong

“…The clinical interpretation of genetic variants has come to rely heavily on reference population databases such as the Exome Aggregation Consortium (ExAC)…”
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Cardiac Tumors: Optimal Cardiac MR Sequences and Spectrum of Imaging Appearances by O'Donnell, David H, Abbara, Suhny, Chaithiraphan, Vithaya, Yared, Kibar, Killeen, Ronan P, Cury, Ricardo C, Dodd, Jonathan D

“…This article reviews the optimal cardiac MRI sequences for and the spectrum of imaging appearances of cardiac tumors. Recent technologic advances in cardiac…”
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Image Gallery: Symmetrical bilateral acrometastases of the great toes in metastatic renal cell carcinoma by O'Driscoll, D., Palial, K., O'Donnell, H., Pratsou, P.

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MethylomeDB: a database of DNA methylation profiles of the brain by Xin, Yurong, Chanrion, Benjamin, O'Donnell, Anne H., Milekic, Maria, Costa, Ramiro, Ge, Yongchao, Haghighi, Fatemeh G.

“…MethylomeDB (http://epigenomics.columbia.edu/methylomedb/index.html) is a new database containing genome-wide brain DNA methylation profiles. DNA methylation…”
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Retrospective evaluation of adjuvant capecitabine dosing patterns in triple negative breast cancer by Lin, Kun, Michaels, Elena, Polley, Eric, O'Donnell, Peter H, Howard, Frederick M, Hahn, Olwen, Fleming, Gini F, Nanda, Rita, Chen, Nan, Yang, Heng

“…The CREATE-X trial demonstrated that adjuvant capecitabine was effective in prolonging survival in high-risk triple-negative breast cancer (TNBC) patients…”
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The ImPreSS Trial: Implementation of Point‐of‐Care Pharmacogenomic Decision Support in Perioperative Care by Truong, Tien M., Apfelbaum, Jeffrey, Shahul, Sajid, Anitescu, Magdalena, Danahey, Keith, Knoebel, Randall W., Liebovitz, David, Karrison, Theodore, Wijk, Xander M.R., Yeo, Kiang‐Teck J., Meltzer, David, Ratain, Mark J., O'Donnell, Peter H.

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Increased DNA methylation in the suicide brain by HAGHIGHI, Fatemeh, YURONG XIN, CHANRION, Benjamin, O'DONNELL, Anne H, YONGCHAO GE, DWORK, Andrew J, ARANGO, Victoria, MANN, J. John

“…Clinical studies find that childhood adversity and stressful life events in adulthood increase the risk for major depression and for suicide. The…”
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