Search Results - "O'Connor, B. J."

Superiority of "triple" therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD by Singh, D, Brooks, J, Hagan, G, Cahn, A, O'Connor, B J

“…The combination of salmeterol and fluticasone propionate (SFC) and tiotropium bromide (TIO) are commonly used treatments in chronic obstructive pulmonary…”
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DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents by O'CONNOR, J. P. B, JACKSON, A, PARKER, G. J. M, JAYSON, G. C

“…Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is now frequently used in early clinical trial assessment of antiangiogenic and vascular…”
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Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics by Diamant, Z., Sidharta, P. N., Singh, D., O'Connor, B. J., Zuiker, R., Leaker, B. R., Silkey, M., Dingemanse, J.

“…Summary Background CRTH2 is a G‐protein‐coupled receptor on T helper2 cells that mediates pro‐inflammatory effects of prostaglandin D2 in allergic responses…”
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The effects of the novel SHIP1 activator AQX-1125 on allergen-induced responses in mild-to-moderate asthma by Leaker, B. R., Barnes, P. J., O'Connor, B. J., Ali, F. Y., Tam, P., Neville, J., Mackenzie, L. F., MacRury, T.

“…Summary Background SH2‐containing inositol‐5′‐phosphatase 1 (SHIP1) is an endogenous inhibitor of the phosphoinositide‐3‐kinase pathway that is involved in the…”
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Bronchoabsorption; a novel bronchoscopic technique to improve biomarker sampling of the airway by Leaker, B R, Nicholson, G C, Ali, F Y, Daudi, N, O'Connor, B J, Barnes, P J

“…Current techniques used to obtain lung samples have significant limitations and do not provide reproducible biomarkers of inflammation. We have developed a…”
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The 5-lipoxygenase-activating protein inhibitor, GSK2190915, attenuates the early and late responses to inhaled allergen in mild asthma by Kent, S. E., Boyce, M., Diamant, Z., Singh, D., O'Connor, B. J., Saggu, P. S., Norris, V.

“…Summary Background GSK2190915, a potent 5‐lipoxygenase‐activating protein inhibitor, prevents the synthesis of leukotrienes and…”
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The incidence of adenocarcinoma and dysplasia in Barrett’s esophagus: Report on the cleveland clinic barrett’s esophagus registry by O’Connor, J.Barry, Falk, Gary W, Richter, Joel E

“…OBJECTIVE: The reported incidence of adenocarcinoma in Barrett’s esophagus is variable. The aim of this study was to determine the incidence of dysplasia and…”
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A two-part Phase II study of cediranib in patients with advanced solid tumours: the effect of food on single-dose pharmacokinetics and an evaluation of safety, efficacy and imaging pharmacodynamics by Mitchell, Claire L., O’Connor, J. P. B., Roberts, C., Watson, Y., Jackson, A., Cheung, S., Evans, J., Spicer, J., Harris, A., Kelly, C., Rudman, S., Middleton, M., Fielding, A., Tessier, J., Young, H., Parker, G. J. M., Jayson, G. C.

“…Background Cediranib (RECENTIN™) is an oral, highly potent VEGF inhibitor. This study evaluated the effect of food on the pharmacokinetics of cediranib and…”
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Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects by Brown, R. A, Clarke, G. W, Ledbetter, C. L, Hurle, M. J, Denyer, J. C, Simcock, D. E, Coote, J. E, Savage, T. J, Murdoch, R. D, Page, C. P, Spina, D, O'Connor, B. J

“…Asthmatics, unlike healthy subjects, experience bronchoconstriction in response to inhaled adenosine, and extracellular adenosine concentrations are elevated…”
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A reformulation of pLSA for uncertainty estimation and hypothesis testing in bio-imaging by Tar, P D, Thacker, N A, Deepaisarn, S, O’Connor, J P B, McMahon, A W

“…Abstract Motivation Probabilistic latent semantic analysis (pLSA) is commonly applied to describe mass spectra (MS) images. However, the method does not…”
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Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract by Kharitonov, S A, Chung, K F, Evans, D, O'Connor, B J, Barnes, P J

“…Nitric oxide (NO) is detectable in the exhaled air of human subjects, and its concentration is increased in patients with asthma. We have investigated the…”
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DCE-MRI biomarkers of tumour heterogeneity predict CRC liver metastasis shrinkage following bevacizumab and FOLFOX-6 by O'Connor, J P B, Rose, C J, Jackson, A, Watson, Y, Cheung, S, Maders, F, Whitcher, B J, Roberts, C, Buonaccorsi, G A, Thompson, G, Clamp, A R, Jayson, G C, Parker, G J M

“…Background: There is limited evidence that imaging biomarkers can predict subsequent response to therapy. Such prognostic and/or predictive biomarkers would…”
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Cellular profiles in asthmatic airways: a comparison of induced sputum, bronchial washings, and bronchoalveolar lavage fluid by Keatings, V M, Evans, D J, O'Connor, B J, Barnes, P J

“…BACKGROUND: Analysis of bronchoalveolar lavage fluid has improved our understanding of the pathogenesis of asthma. Safety issues and access to expert resources…”
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novel technique to explore the functions of bronchial mucosal T cells in chronic obstructive pulmonary disease: application to cytotoxicity and cytokine immunoreactivity by Lethbridge, M.W, Kemeny, D.M, Ratoff, J.C, O'Connor, B.J, Hawrylowicz, C.M, Corrigan, C.J

“…Bronchial mucosal CD8⁺ cells are implicated in chronic obstructive pulmonary disease (COPD) pathogenesis, but there are few data on their functional…”
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A new method for the high-precision assessment of tumor changes in response to treatment by Tar, P D, Thacker, N A, Babur, M, Watson, Y, Cheung, S, Little, R A, Gieling, R G, Williams, K J, O'Connor, J P B

“…Abstract Motivation Imaging demonstrates that preclinical and human tumors are heterogeneous, i.e. a single tumor can exhibit multiple regions that behave…”
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Heparin and structurally related polymers attenuate eotaxin‐1 (CCL11) release from human airway smooth muscle by Kanabar, V, Page, C P, Simcock, D E, Karner, C, Mahn, K, O'Connor, B J, Hirst, S J

“…Background and purpose: The glycosaminoglycan heparin has anti‐inflammatory activity and is exclusively found in mast cells, which are localized within airway…”
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A Comparison of Low-Dose Inhaled Budesonide plus Theophylline and High-Dose Inhaled Budesonide for Moderate Asthma by Evans, David J, Taylor, David A, Zetterstrom, Olle, Chung, K. Fan, O'Connor, Brian J, Barnes, Peter J

“…Inhaled glucocorticoids have become the mainstay of therapy in asthma, with dose titration until control is achieved. 1 Although it is effective, the long-term…”
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Inhaled endotoxin in healthy human subjects: A dose-related study on systemic effects and peripheral CD4+ and CD8+ T cells by Loh, L.C., Vyas, B., Kanabar, V., Kemeny, D.M., O’Connor, B.J.

“…Inhaled endotoxin or lipopolysaccharide (LPS) is implicated in the pathogenesis of pulmonary diseases. We investigated the inhalation effects of two different…”
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Hydrofluoroalkane-134a beclomethasone dipropionate extrafine aerosol provides equivalent asthma control to chlorofluorocarbon beclomethasone dipropionate at approximately half the total daily dose by Davies, R.J., Stampone, P., O'Connor, B.J.

“…The mandatory requirement to eliminate chlorofluorocarbons (CFCs) as propellants in pharmaceutical aerosols has provided the opportunity to enhance…”
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Effect of inhaled budesonide on lung function and airway inflammation : Assessment by various inflammatory markers in mild asthma by LIM, S, JATAKANON, A, JOHN, M, GILBEY, T, O'CONNOR, B. J, KIAN FAN CHUNG, BARNES, P. J

“…In a double-blind, cross-over study, we examined the effect of inhaled budesonide (800 microgram twice daily via Turbohaler) on lung function and various…”
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