Search Results - "O'Connell, Matthew J"

Initiation of DNA damage responses through XPG-related nucleases by Kuntz, Karen, O'Connell, Matthew J

“…Lesion‐specific enzymes repair different forms of DNA damage, yet all lesions elicit the same checkpoint response. The common intermediate required to mount a…”
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An acetyltransferase-independent function of Eso1 regulates centromere cohesion by Lin, Su-Jiun, Tapia-Alveal, Claudia, Jabado, Omar J, Germain, Doris, O'Connell, Matthew J

“…Eukaryotes contain three essential Structural Maintenance of Chromosomes (SMC) complexes: cohesin, condensin, and Smc5/6. Cohesin forms a ring-shaped structure…”
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Smc5/6 Is Required for Repair at Collapsed Replication Forks by Ampatzidou, Eleni, Irmisch, Anja, O'Connell, Matthew J, Murray, Johanne M

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The G2 DNA damage checkpoint: Could this ancient regulator be the Achilles heel of cancer? by Kuntz, Karen, O'Connell, Matthew J.

“…The maintenance of genomic integrity is important in normal cell growth and organism development, as well as in the prevention of cancer.  Cell cycle…”
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Smc5/6 maintains stalled replication forks in a recombination-competent conformation by Irmisch, Anja, Ampatzidou, Eleni, Mizuno, Ken'ichi, O'Connell, Matthew J, Murray, Johanne M

“…The Smc5/6 structural maintenance of chromosomes complex is required for efficient homologous recombination (HR). Defects in Smc5/6 result in chromosome…”
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Regulatory motifs in Chk1 by Caparelli, Michael L., O'Connell, Matthew J.

“…Chk1 is the effector kinase of the G 2 DNA damage checkpoint. Chk1 homologs possess a highly conserved N-terminal kinase domain and a less conserved C-terminal…”
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Histone H3 Lysine 14 Acetylation Is Required for Activation of a DNA Damage Checkpoint in Fission Yeast by Wang, Yu, Kallgren, Scott P., Reddy, Bharat D., Kuntz, Karen, López-Maury, Luis, Thompson, James, Watt, Stephen, Ma, Chun, Hou, Haitong, Shi, Yang, Yates, John R., Bähler, Jürg, O'Connell, Matthew J., Jia, Songtao

“…Histone lysine acetylation has emerged as a key regulator of genome organization. However, with a few exceptions, the contribution of each acetylated lysine to…”
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Regulation of TIP60 by ATF2 Modulates ATM Activation by Bhoumik, Anindita, Singha, Netai, O'Connell, Matthew J., Ronai, Ze'ev A.

“…TIP60 (HTATIP) is a histone acetyltransferase (HAT) whose function is critical in regulating ataxia-telangiectasia mutated (ATM) activation, gene expression,…”
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Regulation of Chk1 by its C-terminal domain by Kosoy, Ana, O'Connell, Matthew J

“…Chk1 is a protein kinase that is the effector molecule in the G2 DNA damage checkpoint. Chk1 homologues have an N-terminal kinase domain, and a C-terminal…”
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Regulation of chk1 by Tapia-Alveal, Claudia, Calonge, Teresa M, O'Connell, Matthew J

“…Chk1 is a serine/threonine protein kinase that is the effector of the G2 DNA damage checkpoint. Chk1 homologs have a highly conserved N-terminal kinase domain,…”
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Smc5-Smc6-Dependent Removal of Cohesin from Mitotic Chromosomes by Outwin, Emily A., Irmisch, Anja, Murray, Johanne M., O'Connell, Matthew J.

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Fission Yeast Rnf4 Homologs Are Required for DNA Repair by Kosoy, Ana, Calonge, Teresa M., Outwin, Emily A., O'Connell, Matthew J.

“…We describe two RING finger proteins in the fission yeast Schizosaccharomyces pombe, Rfp1 and Rfp2. We show that these proteins function redundantly in DNA…”
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G2 damage checkpoints: what is the turn-on? by O'Connell, Matthew J, Cimprich, Karlene A

“…Cells mount a coordinated response to DNA damage, activating DNA repair pathways and cell-cycle checkpoint pathways to allow time for DNA repair to occur. In…”
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The G2 DNA damage checkpoint targets both Wee1 and Cdc25 by Raleigh, Jeanette M., O’Connell, Matthew J.

“…ABSTRACT The onset of mitosis is controlled by the cyclin dependent kinase Cdc2p. Cdc2p activity is controlled through the balance of phosphorylation and…”
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Phytochelatin Synthase Genes from Arabidopsis and the Yeast Schizosaccharomyces pombe by Ha, Suk-Bong, Smith, Aaron P., Howden, Ross, Dietrich, Wendy M., Bugg, Sarah, O'Connell, Matthew J., Goldsbrough, Peter B., Cobbett, Christopher S.

“…Phytochelatins (PCs), a family of heavy metal-inducible peptides important in the detoxification of heavy metals, have been identified in plants and some…”
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SMC complexes and topoisomerase II work together so that sister chromatids can work apart by Tapia-Alveal, Claudia, Outwin, Emily A., Trempolec, Natalia, Dziadkowiec, Dorota, Murray, Johanne M., O'Connell, Matthew J.

“…The pairing of sister chromatids in interphase facilitates error-free homologous recombination (HR). Sister chromatids are held together by cohesin, one of…”
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Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1 by den Elzen, Nicole R, O'Connell, Matthew J

“…The G2 DNA damage checkpoint delays mitotic entry via the upregulation of Wee1 kinase and the downregulation of Cdc25 phosphatase by Chk1 kinase, and resultant…”
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Molecular mechanisms involved in initiation of the DNA damage response by Barnum, Kevin J, O'Connell, Matthew J

“…DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle…”
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Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest by Capasso, Holly, Palermo, Carmela, Wan, Shanhong, Rao, Hui, John, Ulrik P, O'Connell, Matthew J, Walworth, Nancy C

“…In the fission yeast Schizosaccharomyces pombe, the protein kinase Chk1 has an essential role in transducing a delay signal to the cell cycle machinery in the…”
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Cell cycle regulation by checkpoints by Barnum, Kevin J, O'Connell, Matthew J

“…Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth…”
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