Search Results - "O'Connell, Kara E"

Pro-inflammatory cytokine levels are raised in female schizophrenia patients treated with clozapine by O'Connell, Kara E, Thakore, Jogin, Dev, Kumlesh K

“…Abstract Background We have previously shown that the neurotrophic factor, S100B, is raised in serum samples of female patients with schizophrenia, but not…”
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The premium of a big pharma license deal by O'Connell, Kara E, Frei, Patrik, Dev, Kumlesh K

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In vitro and ex vivo models of multiple sclerosis by Madill, Martin, Fitzgerald, Denise, O’Connell, Kara E., Dev, Kumlesh K., Shen, Sanbing, FitzGerald, Una

“…•Boosting remyelination and nerve repair should be a property of novel MS therapies.•Primary oligodendrocyte and brain slice cultures could accelerate MS drug…”
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A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson’s disease by Dutta, Priyanka, Dargahi, Leila, O’Connell, Kara E., Bolia, Ashini, Ozkan, Banu, Sailer, Andreas W., Dev, Kumlesh K.

“…[Display omitted] •PAEL receptor interacts with GABARAPL2.•GABARAPL2 modulates levels of PAEL receptor.•In silico modelling supports PAEL receptor interaction…”
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The protein interacting with C‐kinase (PICK1) interacts with and attenuates parkin‐associated endothelial‐like (PAEL) receptor‐mediated cell death by Dutta, Priyanka, O'Connell, Kara E., Ozkan, Sefika B., Sailer, Andreas W., Dev, Kumlesh K.

“…The parkin‐associated endothelial‐like receptor (PAELR, GPR37) is an orphan G protein‐coupled receptor that interacts with and is degraded by parkin‐mediated…”
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Inhibition of the Interaction Between Group I Metabotropic Glutamate Receptors and PDZ-Domain Proteins Prevents Hippocampal Long-Term Depression, but Not Long-Term Potentiation by Neyman, Sergey, Braunewell, Karl-Heinz, O'Connell, Kara E, Dev, Kumlesh K, Manahan-Vaughan, Denise

“…The group I metabotropic glutamate (mGlu) receptor subtypes, mGlu1 and mGlu5, strongly regulate hippocampal synaptic plasticity. Both harbor…”
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Increased interleukin 23 (IL23) levels in schizophrenia patients treated with depot antipsychotic medication by O’Connell, Kara E., Thakore, Jogin, Dev, Kumlesh K.

“…•We examine IL23 levels in patients with schizophrenia compared to controls.•These levels were correlated with treatment time, age and illness severity.•IL23…”
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The use of cytokine signature patterns: separating drug naïve, interferon and natalizumab-treated multiple sclerosis patients by O'Connell, Kara E., Mok, Tzehow, Sweeney, Brian, Ryan, Aisling M., Dev, Kumlesh K.

“…Abstract Multiple sclerosis (MS) is an inflammatory illness characterized by demyelination and axonal neurodegeneration. Here, we used serum samples from MS…”
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The spectrum of psychosis in multiple sclerosis: a clinical case series by Gilberthorpe, Thomas G, O'Connell, Kara E, Carolan, Alison, Silber, Eli, Brex, Peter A, Sibtain, Naomi A, David, Anthony S

“…Psychosis in the context of multiple sclerosis (MS) has previously been reported as a rare occurrence. However, recent epidemiological studies have found…”
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