Search Results - "O'Callaghan, Grace"

MicroRNA-146a is upregulated by and negatively regulates TLR2 signaling by Quinn, Edel M, Wang, Jiang Huai, O'Callaghan, Grace, Redmond, H Paul

“…TLR signaling is a crucial component of the innate immune response to infection. MicroRNAs (miRNAs) have been shown to be upregulated during TLR signaling…”
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Interplay between microbial‐derived GABA and host GABA receptor signaling collectively influence the tumorigenic function of GABA in colon cancer by Keane, Jonathan M., Fernandes, Philana, Kratz, Florian, O'Callaghan, Grace, Gahan, Cormac G. M., Joyce, Susan A., Stanton, Catherine, Hyland, Niall P., Houston, Aileen

“…Although classically recognized as a neurotransmitter, gamma aminobutyric acid (GABA) has also been identified in colonic tumors. Moreover, the gut microbiome…”
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Targeting the EP1 receptor reduces Fas ligand expression and increases the antitumor immune response in an in vivo model of colon cancer by O'Callaghan, Grace, Ryan, Aideen, Neary, Peter, O'Mahony, Caitlin, Shanahan, Fergus, Houston, Aileen

“…Despite studies demonstrating that inhibition of cyclooxygenase‐2 (COX‐2)‐derived prostaglandin E2 (PGE2) has significant chemotherapeutic benefits in vitro…”
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The Role of Ivacaftor in Severe Cystic Fibrosis in a Patient With the R117H Mutation by Ronan, Nicola J., MBBCh, Fleming, Claire, BSc, O'Callaghan, Grace, PhD, Maher, Michael M., MBBCh, MD, Murphy, Desmond M., MBBCh, PhD, FCCP, Plant, Barry J., MBBCh, MD

“…Cystic fibrosis (CF) conductance transmembrane regulator functions as a chloride (Cl– ) channel in multiple organs, including the lungs. More than 1,800…”
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The effects of freezing on faecal microbiota as determined using MiSeq sequencing and culture-based investigations by Fouhy, Fiona, Deane, Jennifer, Rea, Mary C, O'Sullivan, Órla, Ross, R Paul, O'Callaghan, Grace, Plant, Barry J, Stanton, Catherine

“…High-throughput sequencing has enabled detailed insights into complex microbial environments, including the human gut microbiota. The accuracy of the…”
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Sa1681 Inhibition of the Prostaglandin EP1 Receptor Suppresses Colon Cancer Cell Invasion and Metastasis by O'Callaghan, Grace P, Reagan, Michaela, Flores, Ludmila M, Zhang, Yong, Roccaro, Aldo, Shanahan, Fergus, Ghobrial, Irene, Houston, Aileen

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Mo1615 Targeting Fasl Increases the Anti-Tumor Immune Response in an In Vivo Model of Colon Cancer by O'Callaghan, Grace P, Ryan, Aideen E, Neary, Peter, O'Mahony, Caitlin, Shanahan, Fergus, Houston, Aileen

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Targeting the EP1-FasL Signaling Pathway Reduces Colon Tumor Cell Growth In Vivo by O'Callaghan, Grace P, Neary, Peter, O'Mahony, Caitlin, Shanahan, Fergus, Houston, Aileen

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M1805 Synergy Between Fas and TLR4 in Promoting Pro-Inflammatory Cytokine Synthesis in Macrophages and Intestinal Epithelial Cells – Relevance to IBD by Brint, Elizabeth, O'Callaghan, Grace P, Regan, Tim, Shanahan, Fergus, Houston, Aileen

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Life in the Fas lane: differential outcomes of Fas signaling by Brint, Elizabeth, O’Callaghan, Grace, Houston, Aileen

“…Fas, also known as CD95 or APO-1, is a member of the tumor necrosis factor/nerve growth factor superfamily. Although best characterized in terms of its…”
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W1972 COX-Derived PGE2 Modulates Fasl Expression Via the Ep1 Receptor in Colon Cancer Cells by Houston, Aileen, O'Callaghan, Grace P, Shanahan, Fergus

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A Bifidobacterial pilus‐associated protein promotes colonic epithelial proliferation by O'Connell Motherway, Mary, Houston, Aileen, O’Callaghan, Grace, Reunanen, Justus, O’Brien, Frances, O’Driscoll, Tara, Casey, Patrick G., de Vos, Willem M., van Sinderen, Douwe, Shanahan, Fergus

“…Development of the human gut microbiota commences at birth, with certain bifidobacterial species representing dominant and early colonisers of the newborn…”
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Investigating the Characteristics, Uses, Perceptions, and Barriers of California School Farms by O'Callaghan, Grace

“…The need for agricultural education to be taught is rapidly increasing as the general public becomes less in touch with production agriculture. School farms…”
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CORK Study in Cystic Fibrosis: Sustained Improvements in Ultra-Low-Dose Chest CT Scores After CFTR Modulation With Ivacaftor by Ronan, Nicola J, Einarsson, Gisli G, Twomey, Maria, Mooney, Denver, Mullane, David, NiChroinin, Muireann, O'Callaghan, Grace, Shanahan, Fergus, Murphy, Desmond M, O'Connor, Owen J, Shortt, Cathy A, Tunney, Michael M, Eustace, Joseph A, Maher, Michael M, Elborn, J Stuart, Plant, Barry J

“…Ivacaftor produces significant clinical benefit in patients with cystic fibrosis (CF) with the G551D mutation. Prevalence of this mutation at the Cork CF…”
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Sa1925 Cross-Talk Between Gamma-Aminobutyric Acid and Prostaglandin E2 in Colon Carcinogenesis by O'Callaghan, Grace, Fernandes, Philana, Shanahan, Fergus, Hyland, Niall P, Houston, Aileen

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Tu1247 The Relationship Between Cystic Fibrosis Epithelial Cells and Intestinal Inflammation -Evolving Mechanisms of the Lung-Gut Axis by O'Callaghan, Grace, Houston, Aileen, Foley, Niamh, Shanahan, Fergus, Plant, Barry J

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Tu1677 Upregulation of Fas Ligand Expression Promotes Colon Cancer Cell Migration and Metastasis In Vitro and In Vivo by O'Callaghan, Grace, Reagan, Michaela R, Flores, Ludmila, Zhang, Yong, Azab, Abdel, Roccaro, Aldo, Shanahan, Fergus, Ghobrial, Irene, Houston, Aileen

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Multiple Myeloma-Derived Bone-Marrow Mesenchymal Stem Cells: Microrna-, Gene Expression-Profiling and Functional Characterization by Reagan, Michaela R, Roccaro, Aldo M, Azab, AbdelKareem, Zhang, Yong, O'Callaghan, Grace B, Maiso, Patricia, Manier, Salomon, Kaplan, David L., Ghobrial, Irene M.

“…Abstract 1837 Current research has demonstrated that cancer cells are not only influenced by their microenvironment, but are also able to drastically alter…”
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Nanoparticle Design For Bone-Specific Chemotherapy and Microenvironmental Targeting In Multiple Myeloma by Reagan, Michaela R, Swami, Archana, Basto, Pamela A, Mishima, Yuji, Liu, Jinhe, Glavey, Siobhan, O'Callaghan, Grace B, Moschetta, Michele, Nagano, Kenichi, Baron, Roland, Roccaro, Aldo M, Farokhzad, Omid, Ghobrial, Irene M.

“…The bone marrow (BM) niche is known to exert a protective effect on lymphoid tumors, such as multiple myeloma (MM), where mesenchymal stem cell interactions…”
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Fas ligand expression and tumour immune evasion; the role of prostaglandin E2 and the EP1 receptor by O'Callaghan, Grace

“…Background and Aim: During carcinogenesis, tumours develop multiple mechanisms to evade the immune system and suppress the anti-tumour immune response…”
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