Search Results - "O'CONNOR, S"

CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy by Rodriguez-Garcia, Alba, Lynn, Rachel C., Poussin, Mathilde, Eiva, Monika A., Shaw, Lauren C., O’Connor, Roddy S., Minutolo, Nicholas G., Casado-Medrano, Victoria, Lopez, Gonzalo, Matsuyama, Takami, Powell, Daniel J.

“…The immunosuppressive tumor microenvironment (TME) represents a major barrier for effective immunotherapy. Tumor-associated macrophages (TAMs) are highly…”
Get full text

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal by Liu, Mingen, O’Connor, Roddy S., Trefely, Sophie, Graham, Kathleen, Snyder, Nathaniel W., Beatty, Gregory L.

“…Macrophages enforce antitumor immunity by engulfing and killing tumor cells. Although these functions are determined by a balance of stimulatory and inhibitory…”
Get full text

CAR T cell immunotherapy for human cancer by June, Carl H, O'Connor, Roddy S, Kawalekar, Omkar U, Ghassemi, Saba, Milone, Michael C

“…Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or…”
Get full text

European recommendations and quality assurance for cytogenomic analysis of haematological neoplasms by Rack, K. A., van den Berg, E., Haferlach, C., Beverloo, H. B., Costa, D., Espinet, B., Foot, N., Jeffries, S., Martin, K., O’Connor, S., Schoumans, J., Talley, P., Telford, N., Stioui, S., Zemanova, Z., Hastings, R. J.

“…Cytogenomic investigations of haematological neoplasms, including chromosome banding analysis, fluorescence in situ hybridisation (FISH) and microarray…”
Get full text

Diode pumped yellow dysprosium lasers by Bowman, S R, O'Connor, S, Condon, N J

“…First operation of the 4F₉/₂ → 6H₁₃/₂ laser transition in dysprosium doped yttrium aluminum garnet is reported. Efficient room temperature operation at 583 nm…”
Get full text

Poly(a)morphic portrait of the electrical double layer in ionic liquids by Ivaništšev, V., O’Connor, S., Fedorov, M.V.

“…In this paper we present a unified view on charge-driven structural transitions in the electrical double layer in ionic liquids and summarise molecular-scale…”
Get full text

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis by Xiang, Yan, Stine, Zachary E, Xia, Jinsong, Lu, Yunqi, O'Connor, Roddy S, Altman, Brian J, Hsieh, Annie L, Gouw, Arvin M, Thomas, Ajit G, Gao, Ping, Sun, Linchong, Song, Libing, Yan, Benedict, Slusher, Barbara S, Zhuo, Jingli, Ooi, London L, Lee, Caroline G L, Mancuso, Anthony, McCallion, Andrew S, Le, Anne, Milone, Michael C, Rayport, Stephen, Felsher, Dean W, Dang, Chi V

“…Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation. GLS is being explored as a…”
Get full text

Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene by Sellmyer, Mark A., Richman, Sarah A., Lohith, Katheryn, Hou, Catherine, Weng, Chi-Chang, Mach, Robert H., O’Connor, Roddy S., Milone, Michael C., Farwell, Michael D.

“…Cell-based therapeutics have considerable promise across diverse medical specialties; however, reliable human imaging of the distribution and trafficking of…”
Get full text

Synthesis of Semicrystalline Polyolefin Materials: Precision Methyl Branching via Stereoretentive Chain Walking by Vaccarello, David N, O’Connor, Kyle S, Iacono, Pasquale, Rose, Jeffrey M, Cherian, Anna E, Coates, Geoffrey W

“…We report the discovery of C 2-symmetric nickel catalysts capable of the regio- and isoselective polymerization of 1-butene to produce isotactic…”
Get full text

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations by O’Connor, Roddy S., Guo, Lili, Ghassemi, Saba, Snyder, Nathaniel W., Worth, Andrew J., Weng, Liwei, Kam, Yoonseok, Philipson, Benjamin, Trefely, Sophie, Nunez-Cruz, Selene, Blair, Ian A., June, Carl H., Milone, Michael C.

“…Etomoxir (ETO) is a widely used small-molecule inhibitor of fatty acid oxidation (FAO) through its irreversible inhibitory effects on the carnitine…”
Get full text

Complex history of dog (Canis familiaris) origins and translocations in the Pacific revealed by ancient mitogenomes by Greig, K., Gosling, A., Collins, C. J., Boocock, J., McDonald, K., Addison, D. J., Allen, M. S., David, B., Gibbs, M., Higham, C. F. W., Liu, F., McNiven, I. J., O’Connor, S., Tsang, C. H., Walter, R., Matisoo-Smith, E.

“…Archaeological evidence suggests that dogs were introduced to the islands of Oceania via Island Southeast Asia around 3,300 years ago, and reached the eastern…”
Get full text

Current Status and Challenges of Vaccination Therapy for Glioblastoma by Hosseinalizadeh, Hamed, Rahmati, Mohammad, Ebrahimi, Ammar, O'Connor, Roddy S

“…Glioblastoma (GBM), also known as grade IV astrocytoma, is the most common and deadly type of central nervous system malignancy in adults. Despite significant…”
Get full text

Controlled Chain Walking for the Synthesis of Thermoplastic Polyolefin Elastomers: Synthesis, Structure, and Properties by O’Connor, Kyle S., Watts, Annabelle, Vaidya, Tulaza, LaPointe, Anne M., Hillmyer, Marc A., Coates, Geoffrey W.

“…Thermoplastic elastomers are attractive materials because of their ability to be melt-processed, reused, and recycled, unlike chemically cross-linked…”
Get full text

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells by Kawalekar, Omkar U., O’Connor, Roddy S., Fraietta, Joseph A., Guo, Lili, McGettigan, Shannon E., Posey, Avery D., Patel, Prachi R., Guedan, Sonia, Scholler, John, Keith, Brian, Snyder, Nathaniel W., Blair, Ian A., Milone, Michael C., June, Carl H.

“…Chimeric antigen receptors (CARs) redirect T cell cytotoxicity against cancer cells, providing a promising approach to cancer immunotherapy. Despite extensive…”
Get full text

Cardiac Tumors: Clinical Presentation, Diagnosis, and Management by Poterucha, Timothy J., Kochav, Jonathan, O’Connor, Daniel S., Rosner, Gregg F.

“…Opinion statement Cardiac masses and tumors are a heterogenous group of disorders and include primary tumors (both benign and malignant), metastatic disease,…”
Get full text

7-Ketocholesterol in disease and aging by Anderson, Amelia, Campo, Angielyn, Fulton, Elena, Corwin, Anne, Jerome, 3rd, W Gray, O'Connor, Matthew S

“…7-Ketocholesterol (7KC) is a toxic oxysterol that is associated with many diseases and disabilities of aging, as well as several orphan diseases. 7KC is the…”
Get full text

What Is Organizational History? Toward a Creative Synthesis of History and Organization Studies by GODFREY, PAUL C., HASSARD, JOHN, O'CONNOR, ELLEN S., ROWLINSON, MICHAEL, RUEF, MARTIN

“…As a synthesis of organization theory and historiography, the field of organizational history is mature enough to contribute to wider theoretical and…”
Get full text

An Efficient Path Classification Algorithm Based on Variational Autoencoder to Identify Metastable Path Channels for Complex Conformational Changes by Qiu, Yunrui, O’Connor, Michael S., Xue, Mingyi, Liu, Bojun, Huang, Xuhui

“…Conformational changes (i.e., dynamic transitions between pairs of conformational states) play important roles in many chemical and biological processes…”
Get full text

First record of Protemnodon (Macropodidae: Marsupialia) from Pleistocene lowland New Guinea by Koungoulos, Loukas G., Flannery, Timothy F., O'Connor, S.

“…An isolated molar from the archaeological deposit of Lachitu Cave (RIQ), on the north coast of Sandaun Province, Papua New Guinea represents the first…”
Get full text

Adjuvant Chemotherapy for Stage II Colon Cancer With Poor Prognostic Features by O'CONNOR, Erin S, YU GREENBLATT, David, LOCONTE, Noelle K, GANGNON, Ronald E, LIOU, Jinn-Ing, HEISE, Charles P, SMITH, Maureen A

“…Adjuvant chemotherapy is typically considered for patients with stage II colon cancer characterized by poor prognostic features, including obstruction,…”
Get full text