Search Results - "O'CONNOR, Jacqueline M"

Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models by SHOEMAKER, Alex R, MITTEN, Michael J, BAUCH, Joy, MARSH, Kennan, TAHIR, Steven K, XIUFENYANG, TSE, Christin, FESIK, Stephen W, ROSENBERG, Saul H, ELMORE, Steven W, ADICKES, Jessica, ACKLER, Scott, REFICI, Marion, FERGUSON, Debra, OLEKSIJEW, Anatol, O'CONNOR, Jacqueline M, BAOLE WANG, FROST, David J

“…Purpose: The purpose of this study was to characterize the activity of the Bcl-2 protein family inhibitor ABT-263 in a panel of small cell lung cancer (SCLC)…”
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Predictors of taste acuity in healthy older Europeans by Simpson, Ellen E.A., Rae, Gordon, Parr, Heather, O’Connor, Jacqueline M., Bonham, Maxine, Polito, Angela, Meunier, Nathalie, Andriollo-Sanchez, Maud, Intorre, Federica, Coudray, Charles, Strain, J.J., Stewart-Knox, Barbara

“…► Factors associated with taste acuity in older European adults aged 55–87 years. ► A signal detection approach was used to look the four basic tastes. ►…”
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Preliminary evidence of immune function modulation by thyroid hormones in healthy men and women aged 55–70 years by Hodkinson, Clare F, Simpson, Ellen E A, Beattie, John H, O'Connor, Jacqueline M, Campbell, David J, Strain, J J, Wallace, Julie M W

“…A reciprocal relationship between the endocrine and immune system has been demonstrated under pathophysiological conditions. However, few studies have assessed…”
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The immune system as a physiological indicator of marginal copper status? by Bonham, Maxine, O'Connor, Jacqueline M., Hannigan, Bernadette M., Strain, J. J.

“…Cu appears to have many important functional roles in the body that apparently relate, among others, to the maintenance of immune function, bone health and…”
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Salivary cortisol, stress and mood in healthy older adults: The Zenith study by Simpson, Ellen E.A., McConville, Chris, Rae, Gordon, O’Connor, Jacqueline M., Stewart-Knox, Barbara J., Coudray, Charles, Strain, J.J.

“…The aims of this study were to investigate the relationship between salivary cortisol, stress and mood and to look at the circadian rhythms of positive (PA)…”
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Taste acuity in response to zinc supplementation in older Europeans by Stewart-Knox, Barbara J., Simpson, Ellen E.A., Parr, Heather, Rae, Gordon, Polito, Angela, Intorre, Federica, Andriollo Sanchez, Maud, Meunier, Natalie, O'Connor, Jacqueline M., Maiani, Giuseppe, Coudray, Charles, Strain, J. J.

“…Taste acuity declines with age and may be dependent upon Zn status. The aim of the present double-blind, randomised controlled intervention trial has been to…”
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Effect of copper supplementation on indices of copper status and certain CVD risk markers in young healthy women by Bügel, Susanne, Harper, Angela, Rock, Edmond, O'Connor, Jacqueline M., Bonham, Maxine P., Strain, J. J.

“…Western diets containing suboptimal Cu concentrations could be widespread. A link between marginal Cu deficiency and CVD has been suggested. The objective of…”
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A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo by SHOEMAKER, Alex R, OLEKSIJEW, Anatol, MARSH, Kennan, MCCLELLAN, William, NELLANS, Hugh, NG, Shichung, NIMMER, Paul, O'CONNOR, Jacqueline M, OLTERSDORF, Tilman, WEIGUO QING, WANG SHEN, STAVROPOULOS, Jason, BAUCH, Joy, TAHIR, Stephen K, BAOLE WANG, WARNER, Robert, HAICHAO ZHANG, FESIK, Stephen W, ROSENBERG, Saul H, ELMORE, Steven W, BELLI, Barbara A, BORRE, Tony, BRUNCKO, Milan, DECKWIRTH, Thomas, FROST, David J, JARVIS, Ken, JOSEPH, Mary K

“…Inhibition of the prosurvival members of the Bcl-2 family of proteins represents an attractive strategy for the treatment of cancer. We have previously…”
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Effects of zinc supplementation on cognitive function in healthy middle-aged and older adults: the ZENITH study by Maylor, Elizabeth A., Simpson, Ellen E. A., Secker, David L., Meunier, Nathalie, Andriollo-Sanchez, Maud, Polito, Angela, Stewart-Knox, Barbara, McConville, Chris, O'Connor, Jacqueline M., Coudray, Charles

“…A randomised double-blind placebo-controlled design was employed to investigate the effects of Zn supplementation on cognitive function in 387 healthy adults…”
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Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study by Hininger-Favier, Isabelle, Andriollo-Sanchez, Maud, Arnaud, Josiane, Meunier, Nathalie, Bord, Séverine, Graham, Ciaren, Polito, Angela, Maiani, Giuseppe, O'Connor, Jacqueline M., Coudray, Charles, Roussel, Anne-Marie

“…Given the key role of Zn in many physiological functions, optimal Zn status could be a predictive parameter of successful ageing. However, the benefit of Zn…”
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Effect of Zinc Supplementation on the Immune Status of Healthy Older Individuals Aged 55–70 Years: The ZENITH Study by Hodkinson, Clare F., Kelly, Mary, Alexander, H. Denis, Bradbury, Ian, Robson, Paula J., Bonham, Maxine P., O'Connor, Jacqueline M., Coudray, Charles, Strain, J. J., Wallace, Julie M. W.

“…Aging is associated with alterations in the immune system, effects which may be exacerbated by inadequate zinc (Zn) status. We examined the relationship…”
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Whole Blood Analysis of Phagocytosis, Apoptosis, Cytokine Production, and Leukocyte Subsets in Healthy Older Men and Women: The ZENITH Study by Hodkinson, Clare F., O'Connor, Jacqueline M., Alexander, H. Denis, Bradbury, Ian, Bonham, Maxine P., Hannigan, Bernadette M., Gilmore, William S., Strain, J. J., Wallace, Julie M. W.

“…Few studies to date have examined age-related changes in markers of immune status in healthy older individuals. The immune status of 93 healthy individuals…”
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Effect of zinc supplementation on in vitro copper-induced oxidation of low-density lipoproteins in healthy French subjects aged 55–70 years:the Zenith Study by Feillet-Coudray, Christine, Meunier, Nathalie, Bayle, Dominique, Brandolini-Bunlon, Marion, Andriollo-Sanchez, Maud, O'Connor, Jacqueline M., Maiani, Giuseppe, Roussel, Anne-Marie, Mazur, Andrzej, Coudray, Charles

“…Zn has been shown to possess antioxidant properties in vitro and in vitro. As inadequate dietary Zn intake has been reported in these populations, Zn…”
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Zinc supplementation has no effect on circulating levels of peripheral blood leucocytes and lymphocyte subsets in healthy adult men by Bonham, Maxine, O'Connor, Jacqueline M., Alexander, H. Denis, Coulter, James, Walsh, Paula M., McAnena, Liadhan B., Downes, C. Stephen, Hannigan, Bernadette M., Strain, J. J.

“…As a result of evidence documenting harmful effects of Zn supplementation on immune function and Cu status, thirty-eight men were recruited onto a Zn…”
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Zinc supplementation has no effect on lipoprotein metabolism, hemostasis, and putative indices of copper status in healthy men by Bonham, Maxine, O'Connor, Jacqueline M, McAnena, Liadhan B, Walsh, Paula M, Downes, C Stephen, Hannigan, Bernadette M, Strain, J J

“…Pharmacological doses of zinc can adversely affect body copper status. The resulting copper deficiency can impact directly upon cholesterol metabolism and a…”
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An inhibitor of Bcl-2 family proteins induces regression of solid tumours by Fesik, Stephen W, Rosenberg, Saul H, Oltersdorf, Tilman, Elmore, Steven W, Shoemaker, Alexander R, Armstrong, Robert C, Augeri, David J, Belli, Barbara A, Bruncko, Milan, Deckwerth, Thomas L, Dinges, Jurgen, Hajduk, Philip J, Joseph, Mary K, Kitada, Shinichi, Korsmeyer, Stanley J, Kunzer, Aaron R, Letai, Anthony, Li, Chi, Mitten, Michael J, Nettesheim, David G, Ng, ShiChung, Nimmer, Paul M, O'Connor, Jacqueline M, Oleksijew, Anatol, Petros, Andrew M, Reed, John C, Shen, Wang, Tahir, Stephen K, Thompson, Craig B, Tomaselli, Kevin J, Wang, Baole, Wendt, Michael D, Zhang, Haichao

“…Proteins in the Bcl-2 family are central regulators of programmed cell death, and members that inhibit apoptosis, such as Bcl-XL and Bcl-2, are overexpressed…”
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No Antioxidant Beneficial Effect of Zinc Supplementation on Oxidative Stress Markers and Antioxidant Defenses in Middle-Aged and Elderly Subjects: The Zenith Study by Andriollo-Sanchez, Maud, Hininger-Favier, Isabelle, Meunier, Nathalie, Venneria, Eugenia, O'Connor, Jacqueline M, Maiani, Giuseppe, Polito, Angela, Bord, Séverine, Ferry, Monique, Coudray, Charles, Roussel, Anne-Marie

“…OBJECTIVE: The aim of the study was to investigate whether zinc supplementation affects antioxidant status in European middle-aged and elderly people. DESIGN:…”
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The effect of copper supplementation on red blood cell oxidizability and plasma antioxidants in middle-aged healthy volunteers by Rock, Edmond, Mazur, Andrzej, O’connor, Jacqueline M., Bonham, Maxine P., Rayssiguier, Yves, Strain, John J.

“…A multicenter European study (FoodCue) was undertaken to provide data on the significance of increased dietary copper as a pro-oxidant or antioxidant in vivo…”
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Vitamin d status and indices of bone turnover in older European adults by Seamans, Kelly M, Hill, Tom R, Scully, Lisa, Meunier, Nathalie, Andrillo-Sanchez, Maude, Polito, Angela, Hininger-Favier, Isabelle, Ciarapica, Donatella, Simpson, Elizabeth E A, Stewart-Knox, Barbara J, O Connor, Jacqueline M, Coudray, Charles, Cashman, Kevin D

“…An increased rate of bone turnover increases risk of osteoporotic fracture later in life. The concentration of 25-hydroxyvitamin D that contributes to an…”
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Copper supplementation in humans does not affect the susceptibility of low density lipoprotein to in vitro induced oxidation (FOODCUE project) by Turley, Eithne, McKeown, Andrea, Bonham, Maxine P., O’Connor, Jacqueline M., Chopra, Mridula, Harvey, Linda J., Majsak-Newman, Gosia, Fairweather-Tait, Susan J., Bügel, Susanne, Sandström, Brittmarie, Rock, Edmond, Mazur, Andrzej, Rayssiguier, Yves, Strain, J.J.

“…The oxidative modification of low-density lipoprotein cholesterol (LDL) has been implicated in the pathogenesis of atherosclerosis. Copper (Cu) is essential…”
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