Search Results - "O'CONNELL, Allison"

Noninvasive Detection of Response and Resistance in EGFR-Mutant Lung Cancer Using Quantitative Next-Generation Genotyping of Cell-Free Plasma DNA by OXNARD, Geoffrey R, PAWELETZ, Cloud P, JÄNNE, Pasi A, YANAN KUANG, MACH, Stacy L, O'CONNELL, Allison, MESSINEO, Melissa M, LUKE, Jason J, BUTANEY, Mohit, KIRSCHMEIER, Paul, JACKMAN, David M

“…Tumor genotyping using cell-free plasma DNA (cfDNA) has the potential to allow noninvasive assessment of tumor biology, yet many existing assays are cumbersome…”
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Bias-Corrected Targeted Next-Generation Sequencing for Rapid, Multiplexed Detection of Actionable Alterations in Cell-Free DNA from Advanced Lung Cancer Patients by Paweletz, Cloud P, Sacher, Adrian G, Raymond, Chris K, Alden, Ryan S, O'Connell, Allison, Mach, Stacy L, Kuang, Yanan, Gandhi, Leena, Kirschmeier, Paul, English, Jessie M, Lim, Lee P, Jänne, Pasi A, Oxnard, Geoffrey R

“…Tumor genotyping is a powerful tool for guiding non-small cell lung cancer (NSCLC) care; however, comprehensive tumor genotyping can be logistically…”
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Thermodynamic examination of pH and magnesium effect on U6 RNA internal loop by O'Connell, Allison A, Hanson, Jared A, McCaskill, Darryl C, Moore, Ethan T, Lewis, Daniel C, Grover, Neena

“…U6 RNA contains a 1 × 2-nt internal loop that folds and unfold during spliceosomal assembly and activation. The 1 × 2 loop consists of a C •A base pair that…”
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Prospective Validation of Rapid Plasma Genotyping for the Detection of EGFR and KRAS Mutations in Advanced Lung Cancer by Sacher, Adrian G, Paweletz, Cloud, Dahlberg, Suzanne E, Alden, Ryan S, O'Connell, Allison, Feeney, Nora, Mach, Stacy L, Jänne, Pasi A, Oxnard, Geoffrey R

“…Plasma genotyping of cell-free DNA has the potential to allow for rapid noninvasive genotyping while avoiding the inherent shortcomings of tissue genotyping…”
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Enhancing antibody-dependent cell-mediated cytotoxicity: a strategy for improving antibody-based immunotherapy by Zahavi, David, AlDeghaither, Dalal, O’Connell, Allison, Weiner, Louis M

“…ABSTRACT The targeting of surface antigens expressed on tumor cells by monoclonal antibodies (mAbs) has revolutionized cancer therapeutics. One mechanism of…”
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A Mechanism of Resistance to Antibody-Targeted Immune Attack by Aldeghaither, Dalal S, Zahavi, David J, Murray, Joseph C, Fertig, Elana J, Graham, Garrett T, Zhang, Yong-Wei, O'Connell, Allison, Ma, Junfeng, Jablonski, Sandra A, Weiner, Louis M

“…Targeted monoclonal antibody therapy is a promising therapeutic strategy for cancer, and antibody-dependent cell-mediated cytotoxicity (ADCC) represents a…”
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Monitoring of Response and Resistance in Plasma of EGFR-Mutant Lung Cancer Using Droplet Digital PCR by Kuang, Yanan, O'Connell, Allison, Sacher, Adrian G, Feeney, Nora, Alden, Ryan S, Oxnard, Geoffrey R, Paweletz, Cloud P

“…The identification of oncogenic driver mutations has led to the rapid rise of genotype-directed treatments. However, genetic analysis of tumors remains…”
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A Prospective Evaluation of Circulating Tumor Cells and Cell-Free DNA in EGFR-Mutant Non-Small Cell Lung Cancer Patients Treated with Erlotinib on a Phase II Trial by Yanagita, Masahiko, Redig, Amanda J, Paweletz, Cloud P, Dahlberg, Suzanne E, O'Connell, Allison, Feeney, Nora, Taibi, Myriam, Boucher, David, Oxnard, Geoffrey R, Johnson, Bruce E, Costa, Daniel B, Jackman, David M, Jänne, Pasi A

“…Genotype-directed therapy is the standard of care for advanced non-small cell lung cancer (NSCLC), but obtaining tumor tissue for genotyping remains a…”
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Thermodynamic Examination of the U6 ISL RNA Bulge by Lewis, Daniel, Grover, Neena, O'Connell, Allison

“…Abstract only Spliceosome is large complex made up of five snRNA and nearly 70 proteins that assembles on pre‐mRNA to excise the introns. The U6 subunit of the…”
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Thermodynamic Examination of U6 ISL Bulged RNA by O'Connell, Allison, Grover, Neena

“…There is a highly conserved bulge in the internal stem‐loop (ISL) of the U6 subunit of the spliceosome. It is responsible for spliseosome activation and…”
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A prospective validation of plasma ddPCR for rapid EGFR and KRAS genotyping of advanced NSCLC patients (pts) by Sacher, Adrian G., Paweletz, Cloud, Alden, Ryan, O'Connell, Allison, Mach, Stacy L., Janne, Pasi A., Oxnard, Geoffrey R.

“…Abstract only…”
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A prospective evaluation of cell free DNA (cfDNA) genotyping and circulating tumor cells (CTC) in EGFR mutant NSCLC patients (pts) treated with erlotinib by Yanagita, Masahiko, Paweletz, Cloud, O'Connell, Allison, Jackman, David Michael, Kuang, Yanan, Oxnard, Geoffrey R., Janne, Pasi A.

“…Abstract only…”
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Abstract 939: Serial monitoring of EGFR mutations in plasma and matched tissue from EGFR mutant non-small cell lung cancer patients on erlotinib by Paweletz, Cloud P., Oxnard, Geoffrey R., Kuang, Yanan, O'Connell, Allison, Yanagita, Masahiko, Messineo, Melissa M., Kirschmeier, Paul, English, Jessie M., Jackman, David M., Jänne, Pasi A.

“…Abstract Tumor genotyping has become standard in the care of non-small cell lung cancer (NSCLC), colorectal cancer, and melanoma because of its power in…”
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Abstract 928: Bias-corrected next generation sequencing of cell free DNA for detection of actionable mutations and rearrangements in advanced non-small cell lung cancer by Paweletz, Cloud P., Raymond, Chris K., Sacher, Adrian G., Kuang, Yanan, O'Connell, Allison, Lim, Lee, Li, Mark, Armour, Chris, English, Jessie M., Kirschmeier, Paul T., Jänne, Pasi A., Oxnard, Geoffrey

“…Abstract Genotype-directed targeted therapies are transforming the care of advanced cancer. However, having adequate tumor tissue for comprehensive genotyping…”
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Abstract 1451: Modeling patient-derived lung cancer in mice: Preclinical tool for drug development by Gokhale, Prafulla C., Palakurthi, Sangeetha, Xu, Man, Calles, Antonio, Shah, Shruti D., O'Connell, Allison, Messineo, Melissa, Kuang, Yanan, Yanagita, Masahiko, Ali, Mosab, Tran, Cam Anh, Choi, Jihyun, Ogino, Atsuko, Butaney, Mohit, Redig, Amanda J., Paweletz, Cloud, Kirschmeier, Paul T., Jänne, Pasi A.

“…Abstract Background: Genotype directed treatment is the standard of care for patients with advanced non-small cell lung cancer (NSCLC). However, acquired drug…”
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Navigation in the Presence of Obstacles for an Agile Autonomous Underwater Vehicle by Xanthidis, Marios, Karapetyan, Nare, Damron, Hunter, Rahman, Sharmin, Johnson, James, O'Connell, Allison, O'Kane, Jason M., Rekleitis, Ioannis

“…Navigation underwater traditionally is done by keeping a safe distance from obstacles, resulting in "fly-overs" of the area of interest. Movement of an…”
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Evaluating and Personalizing User-Perceived Quality of Text-to-Speech Voices for Delivering Mindfulness Meditation with Different Physical Embodiments by Shi, Zhonghao, Chen, Han, Velentza, Anna-Maria, Liu, Siqi, Dennler, Nathaniel, O'Connell, Allison, Matarić, Maja

“…Mindfulness-based therapies have been shown to be effective in improving mental health, and technology-based methods have the potential to expand the…”
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Thermodynamic examination of U6 ISL bulged RNA by OˈConnell, Allison, Grover, Neena

“…Abstract only A highly conserved bulge in the internal stem‐loop (ISL) of the U6 subunit of the spliceosome is responsible for its assembly and catalysis. This…”
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Build Your Own Robot Friend: An Open-Source Learning Module for Accessible and Engaging AI Education by Shi, Zhonghao, O'Connell, Allison, Li, Zongjian, Liu, Siqi, Ayissi, Jennifer, Hoffman, Guy, Soleymani, Mohammad, Matarić, Maja J

“…As artificial intelligence (AI) is playing an increasingly important role in our society and global economy, AI education and literacy have become necessary…”
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Navigation in the Presence of Obstacles for an Agile Autonomous Underwater Vehicle by Xanthidis, Marios, Karapetyan, Nare, Damron, Hunter, Rahman, Sharmin, Johnson, James, O'Connell, Allison, O'Kane, Jason M, Rekleitis, Ioannis

“…Navigation underwater traditionally is done by keeping a safe distance from obstacles, resulting in "fly-overs" of the area of interest. Movement of an…”
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