Search Results - "O'Brien‐Simpson, Neil M."

Staphylococcus aureus membrane vesicles contain immunostimulatory DNA, RNA and peptidoglycan that activate innate immune receptors and induce autophagy by Bitto, Natalie J., Cheng, Lesley, Johnston, Ella L., Pathirana, Rishi, Phan, Thanh Kha, Poon, Ivan K. H., O'Brien‐Simpson, Neil M., Hill, Andrew F., Stinear, Timothy P., Kaparakis‐Liaskos, Maria

“…Gram‐positive bacteria ubiquitously produce membrane vesicles (MVs), and although they contribute to biological functions, our knowledge regarding their…”
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Recent Applications of Aggregation Induced Emission Probes for Antimicrobial Peptide Studies by Luu, Tracey, Li, Wenyi, O'Brien‐Simpson, Neil M., Hong, Yuning

“…Antimicrobial peptides (AMPs) are being intensively investigated as they are considered promising alternatives to antibiotics where their clinical efficacy is…”
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Enhanced Antibacterial Activity of Se Nanoparticles Upon Coating with Recombinant Spider Silk Protein eADF4(κ16) by Huang, Tao, Kumari, Sushma, Herold, Heike, Bargel, Hendrik, Aigner, Tamara B, Heath, Daniel E, O'Brien-Simpson, Neil M, O'Connor, Andrea J, Scheibel, Thomas

“…Selenium nanoparticles (Se NPs) are promising antibacterial agents to tackle the growing problem of antimicrobial resistance. The aim of this study was to…”
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Effect of a protease‐activated receptor‐2 antagonist (GB88) on inflammation‐related loss of alveolar bone in periodontal disease by Francis, Nidhish, Sanaei, Reza, Ayodele, Babatunde A., O'Brien‐Simpson, Neil M., Fairlie, David P., Wijeyewickrema, Lakshmi C., Pike, Robert N., Mackie, Eleanor Jean, Pagel, Charles Neil

“…Background and Objective Protease‐activated receptor‐2 (PAR2), a pro‐inflammatory G‐protein coupled receptor, has been associated with pathogenesis of…”
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Architectural Effects of Star‐Shaped “Structurally Nanoengineered Antimicrobial Peptide Polymers” (SNAPPs) on Their Biological Activity by Shirbin, Steven J., Insua, Ignacio, Holden, James A., Lenzo, Jason C., Reynolds, Eric C., O'Brien‐Simpson, Neil M., Qiao, Greg G.

“…In this work, the effect of two key structural parameters, number of arms and arm length, of star‐shaped “structurally nanoengineered antimicrobial peptide…”
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Keratinocyte‐specific ablation of protease‐activated receptor 2 prevents gingival inflammation and bone loss in a mouse model of periodontal disease by Francis, Nidhish, Ayodele, Babatunde A., O'Brien‐Simpson, Neil M., Birchmeier, Walter, Pike, Robert N., Pagel, Charles N., Mackie, Eleanor J.

“…Chronic periodontitis is characterised by gingival inflammation and alveolar bone loss. A major aetiological agent is Porphyromonas gingivalis, which secretes…”
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The overview of antimicrobial peptide‐coated implants against oral bacterial infections by Sun, Zhe, Ma, Li, Sun, Xiaodong, Sloan, Alastair J., O'Brien‐Simpson, Neil M., Li, Wenyi

“…Dental implants are the most common therapeutic approach for resolving tooth loss and damage. Despite technical advances in treatment, implant failure rates…”
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Interplay between Porphyromonas gingivalis and EGF signalling in the regulation of CXCL14 by Aw, Jiamin, Scholz, Glen M., Huq, Noorjahan Laila, Huynh, Jennifer, O'Brien‐Simpson, Neil M., Reynolds, Eric C.

“…Porphyromonas gingivalis is a keystone pathogen in chronic periodontitis. Its expression of gingipain proteases (Kgp and RgpA/B) is central to the stimulation…”
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Celogentin mimetics as inhibitors of tubulin polymerization by Thombare, Varsha J., Holden, James A., Reynolds, Eric C., O'Brien‐Simpson, Neil M., Hutton, Craig A.

“…Bicyclic analogues of celogentin C have been synthesized in which the side chain–side chain cross‐links are replaced by thioether bonds. Several of the…”
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Adolescent temperament dimensions as stable prospective risk and protective factors for salivary C‐reactive protein by Nelson, Benjamin W., Byrne, Michelle L., Simmons, Julian G., Whittle, Sarah, Schwartz, Orli S., O'Brien‐Simpson, Neil M., Walsh, Katrina A., Reynolds, Eric C., Allen, Nicholas B.

“…Objective Temperament has associations with later physical health outcomes, yet there is a dearth of research exploring the connection between temperament and…”
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GM‐CSF and uPA are required for Porphyromonas gingivalis‐induced alveolar bone loss in a mouse periodontitis model by Lam, Roselind S, O'Brien‐Simpson, Neil M, Hamilton, John A, Lenzo, Jason C, Holden, James A, Brammar, Gail C, Orth, Rebecca K, Tan, Yan, Walsh, Katrina A, Fleetwood, Andrew J, Reynolds, Eric C

“…Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) and urokinase‐type plasminogen activator (uPA) can contribute to the progression of chronic…”
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Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice by Ilievski, Vladimir, Zuchowska, Paulina K, Green, Stefan J, Toth, Peter T, Ragozzino, Michael E, Le, Khuong, Aljewari, Haider W, O'Brien-Simpson, Neil M, Reynolds, Eric C, Watanabe, Keiko

“…The results from cross sectional and longitudinal studies show that periodontitis is closely associated with cognitive impairment (CI) and Alzhemer's Disease…”
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The 9-Fluorenylmethoxycarbonyl (Fmoc) Group in Chemical Peptide Synthesis – Its Past, Present, and Future by Li, Wenyi, Neil M. O’Brien-Simpson, Mohammed Akhter Hossain, Wade, John D

“…The chemical formation of the peptide bond has long fascinated and challenged organic chemists. It requires not only the activation of the carboxyl group of an…”
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Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens by Lin, Bruce, Hung, Andrew, Li, Rong, Barlow, Anders, Singleton, William, Matthyssen, Tamara, Sani, Marc-Antoine, Hossain, Mohammed Akhter, Wade, John D., O'Brien-Simpson, Neil M., Li, Wenyi

“…The World Health Organisation has deemed several multi-drug resistant (MDR) nosocomial bacterial pathogens to be of significant threat to human health. A stark…”
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Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids by Rasines Mazo, Alicia, Allison-Logan, Stephanie, Karimi, Fatemeh, Chan, Nicholas Jun-An, Qiu, Wenlian, Duan, Wei, O'Brien-Simpson, Neil M, Qiao, Greg G

“…Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and tunable cytocompatibility. Macromolecular…”
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A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis by O’Brien-Simpson, Neil M, Holden, James A, Lenzo, Jason C, Tan, Yan, Brammar, Gail C, Walsh, Katrina A, Singleton, William, Orth, Rebecca K H, Slakeski, Nada, Cross, Keith J, Darby, Ivan B, Becher, Dorit, Rowe, Tony, Morelli, Adriana Baz, Hammet, Andrew, Nash, Andrew, Brown, Anna, Ma, Bing, Vingadassalom, Didier, McCluskey, Jacqueline, Kleanthous, Harold, Reynolds, Eric C

“…Porphyromonas gingivalis infected mice with an established P. gingivalis -specific inflammatory immune response were protected from developing alveolar bone…”
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Porphyromonas gingivalis lipopolysaccharide weakly activates M1 and M2 polarized mouse macrophages but induces inflammatory cytokines by Holden, James A, Attard, Troy J, Laughton, Katrina M, Mansell, Ashley, O'Brien-Simpson, Neil M, Reynolds, Eric C

“…Porphyromonas gingivalis is associated with chronic periodontitis, an inflammatory disease of the tooth's supporting tissues. Macrophages are important in…”
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Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles by Fleetwood, Andrew J, Lee, Man K S, Singleton, William, Achuthan, Adrian, Lee, Ming-Chin, O'Brien-Simpson, Neil M, Cook, Andrew D, Murphy, Andrew J, Dashper, Stuart G, Reynolds, Eric C, Hamilton, John A

“…is one of the bacterial species most closely associated with periodontitis and can shed large numbers of outer membrane vesicles (OMVs), which are increasingly…”
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Characterization of proteinase-adhesin complexes of Porphyromonas gingivalis by Pathirana, Rishi D, O'Brien-Simpson, Neil M, Veith, Paul D, Riley, Peter F, Reynolds, Eric C

“…Cooperative Research Centre for Oral Health Science, School of Dental Science, The University of Melbourne, 720 Swanston Street, Victoria, 3010, Australia…”
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Porphyromonas gulae Has Virulence and Immunological Characteristics Similar to Those of the Human Periodontal Pathogen Porphyromonas gingivalis by Lenzo, Jason C, O'Brien-Simpson, Neil M, Orth, Rebecca K, Mitchell, Helen L, Dashper, Stuart G, Reynolds, Eric C

“…Periodontitis is a significant problem in companion animals, and yet little is known about the disease-associated microbiota. A major virulence factor for the…”
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