Search Results - "O'Brien, William A."

Band Anticrossing in Dilute Germanium Carbides Using Hybrid Density Functionals by Stephenson, Chad A., O’brien, William A., Qi, Meng, Penninger, Michael, Schneider, William F., Wistey, Mark A.

“…Dilute germanium carbides (Ge 1− x C x ) offer a direct bandgap for compact silicon photonics, but widely varying properties have been reported. This work…”
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Inhibition of Influenza a Virus Replication by Antagonism of a PI3K-AKT-mTOR Pathway Member Identified by Gene-Trap Insertional Mutagenesis by Murray, James L, McDonald, Natalie J, Sheng, Jinsong, Shaw, Michael W, Hodge, Thomas W, Rubin, Donald H, O'Brien, William A, Smee, Donald F

“…Background: Host genes serving potential roles in virus replication may be exploited as novel antiviral targets. Methods: Small interfering RNA…”
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A functional role for ADAM10 in human immunodeficiency virus type-1 replication by Friedrich, Brian M, Murray, James L, Li, Guangyu, Sheng, Jinsong, Hodge, Thomas W, Rubin, Donald H, O'Brien, William A, Ferguson, Monique R

“…Gene trap insertional mutagenesis was used as a high-throughput approach to discover cellular genes participating in viral infection by screening libraries of…”
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Changes in Plasma HIV-1 RNA and CD4+ Lymphocyte Counts and the Risk of Progression to AIDS by O'Brien, William A, Hartigan, Pamela M, Martin, David, Esinhart, James, Hill, Andrew, Benoit, Sharon, Rubin, Marc, Simberkoff, Michael S, Hamilton, John D

“…Assessments of the efficacy of antiretroviral therapy based on clinical end points in patients with early or intermediate stages of human immunodeficiency…”
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Potential Role for CD63 in CCR5-Mediated Human Immunodeficiency Virus Type 1 Infection of Macrophages by von Lindern, Jana J, Rojo, Daniel, Grovit-Ferbas, Kathie, Yeramian, Christine, Deng, Cheng, Herbein, Georges, Ferguson, Monique R, Pappas, Todd C, Decker, Julie M, Singh, Anjali, Collman, Ronald G, O'Brien, William A

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Saquinavir/Ritonavir: its evolution and current treatment role by O'Brien, 3rd, William A

“…As formulations and combinations of drugs to treat HIV infection improve, physicians are better able to offer therapies that reduce pill burden while…”
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Specificity of the antibody response to the pneumococcal polysaccharide and conjugate vaccines in human immunodeficiency virus-infected adults by Feikin, Daniel R, Elie, Cheryl M, Goetz, Matthew B, Lennox, Jeffrey L, Carlone, George M, Romero-Steiner, Sandra, Holder, Patricia F, O'Brien, William A, Whitney, Cynthia G, Butler, Jay C, Breiman, Robert F

“…Nonspecific antibodies, which are thought to be nonprotective, have been shown to contribute a substantial proportion of the measured concentration in the…”
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Sensitivity of Human Immunodeficiency Virus Type 1 to the Fusion Inhibitor T-20 Is Modulated by Coreceptor Specificity Defined by the V3 Loop of gp120 by Derdeyn, C A, Decker, J M, Sfakianos, J N, Wu, X, O'Brien, W A, Ratner, L, Kappes, J C, Shaw, G M, Hunter, E

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Ge quantum dots encapsulated by AlAs grown by molecular beam epitaxy on GaAs without extended defects by Qi, Meng, Stephenson, Chad A., Protasenko, Vladimir, O’Brien, William A., Mintairov, Alexander, Xing, Huili (Grace), Wistey, Mark A.

“…We demonstrate nearly spherical, strain-free, self-assembled Ge quantum dots (QDs) fully encapsulated by AlAs, grown on (100) GaAs by molecular beam epitaxy…”
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Apoptosis of CD8 + T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4 by Verdin, Eric, Herbein, Georges, Mahlknecht, Ulrich, Batliwalla, Franak, Gregersen, Peter, Pappas, Todd, Butler, John, O'Brien, William A

“…CD8-positive T cells are thought to play an important role in the control of infection by human immunodeficiency virus (HIV) as a result of their cytotoxic…”
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Identification of cellular proteins required for replication of human immunodeficiency virus type 1 by Dziuba, Natallia, Ferguson, Monique R, O'Brien, William A, Sanchez, Anthony, Prussia, Andrew J, McDonald, Natalie J, Friedrich, Brian M, Li, Guangyu, Shaw, Michael W, Sheng, Jinsong, Hodge, Thomas W, Rubin, Donald H, Murray, James L

“…Cellular proteins are essential for human immunodeficiency virus type 1 (HIV-1) replication and may serve as viable new targets for treating infection. Using…”
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Self-assembled Ge QDs Formed by High-Temperature Annealing on Al(Ga)As (001) by O’Brien, William A., Qi, Meng, Yan, Lifan, Stephenson, Chad A., Protasenko, Vladimir, Xing, Huili, Millunchick, Joanna M., Wistey, Mark A.

“…This work studies the spontaneous self-assembly of Ge QDs on AlAs, GaAs and AlGaAs by high-temperature in␣situ annealing using molecular beam epitaxy (MBE)…”
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Sensitivity of Human Immunodeficiency Virus Type 1 to Fusion Inhibitors Targeted to the gp41 First Heptad Repeat Involves Distinct Regions of gp41 and Is Consistently Modulated by gp120 Interactions with the Coreceptor by Derdeyn, C A, Decker, J M, Sfakianos, J N, Zhang, Z, O'Brien, W A, Ratner, L, Shaw, G M, Hunter, E

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Nuclear trafficking of the HIV-1 pre-integration complex depends on the ADAM10 intracellular domain by Endsley, Mark A, Somasunderam, Anoma D, Li, Guangyu, Oezguen, Numan, Thiviyanathan, Varatharasa, Murray, James L, Rubin, Donald H, Hodge, Thomas W, O׳Brien, William A, Lewis, Briana, Ferguson, Monique R

“…Abstract Previously, we showed that ADAM10 is necessary for HIV-1 replication in primary human macrophages and immortalized cell lines. Silencing ADAM10…”
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Gas Source Techniques for Molecular Beam Epitaxy of Highly Mismatched Ge Alloys by Stephenson, Chad A, Gillett-Kunnath, Miriam, O'Brien, William A, Kudrawiec, Robert, Wistey, Mark A

“…Ge and its alloys are attractive candidates for a laser compatible with silicon integrated circuits. Dilute germanium carbide (Ge1-xCx) offers a particularly…”
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A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor by Doranz, B J, Grovit-Ferbas, K, Sharron, M P, Mao, S H, Goetz, M B, Daar, E S, Doms, R W, O'Brien, W A

“…The chemokine receptor CXCR4 is the major coreceptor used for cellular entry by T cell- tropic human immunodeficiency virus (HIV)-1 strains, whereas CCR5 is…”
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A critical role for CD63 in HIV replication and infection of macrophages and cell lines by Chen, Hui, Dziuba, Natallia, Friedrich, Brian, Lindern, Jana von, Murray, James L, Rojo, Daniel R, Hodge, Thomas W, O'Brien, William A, Ferguson, Monique R

“…Abstract HIV infection typically involves interaction of Env with CD4 and a chemokine coreceptor, either CCR5 or CXCR4. Other cellular factors supporting HIV…”
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Combinatorial Selection, Inhibition, and Antiviral Activity of DNA Thioaptamers Targeting the RNase H Domain of HIV-1 Reverse Transcriptase by Somasunderam, Anoma, Ferguson, Monique R, Rojo, Daniel R, Thiviyanathan, Varatharasa, Li, Xin, O'Brien, William A, Gorenstein, David G

“…Despite the key role played by the RNase H of human immunodeficiency virus-1 reverse transcriptase (HIV-1 RT) in viral proliferation, only a few inhibitors of…”
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Randomized trial of the quantitative and functional antibody responses to a 7-valent pneumococcal conjugate vaccine and/or 23-valent polysaccharide vaccine among HIV-infected adults by Feikin, Daniel R., Elie, Cheryl M., Goetz, Matthew B., Lennox, Jeffrey L., Carlone, George M., Romero-Steiner, Sandra, Holder, Patricia F., O’Brien, William A., Whitney, Cynthia G., Butler, Jay C., Breiman, Robert F.

“…In a double-blinded, randomized trial, human immunodeficiency virus (HIV)-infected adults with ≥200 CD4 cells/μl received placebo (PL), 7-valent conjugate, or…”
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Evolution of HIV Resistance Mutations in Patients Maintained on a Stable Treatment Regimen After Virologic Failure by Goetz, Matthew Bidwell, Ferguson, Monique R, Han, Xueliang, McMillan, Greg, Clair, Marty St, Pappa, Keith A, McClernon, Daniel R, OʼBrien, William A

“…OBJECTIVE:We compared the rate of emergence of thymidine analogue mutations (TAMs) and major protease inhibitor mutations in adherent patients who remained on…”
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