Search Results - "O'Brien, WE"

A unique member of the thymidylate kinase family that is induced during macrophage activation by Lee, CG, O'Brien, WE

“…LPS, a bacterial endotoxin, induces the expression of many genes in macrophages. We report the cloning of a novel 3.3-kb cDNA that is a member of the…”
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Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice by Singer, Jonathan B., Hill, Annie E., Burrage, Lindsay C., Olszens, Keith R., Song, Junghan, Justice, Monica, O'Brien, William E., Conti, David V., Witte, John S., Lander, Eric S., Nadeau, Joseph H.

“…Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental,…”
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Mouse Model for Human Arginase Deficiency by Iyer, Ramaswamy K., Yoo, Paul K., Kern, Rita M., Rozengurt, Nora, Tsoa, Rosemarie, O'Brien, William E., Yu, Hong, Grody, Wayne W., Cederbaum, Stephen D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Gene targeting yields a CD18-mutant mouse for study of inflammation by Wilson, RW, Ballantyne, CM, Smith, CW, Montgomery, C, Bradley, A, O'Brien, WE, Beaudet, AL

“…CD18 is the common beta subunit for the heterodimeric leukocyte integrins that mediate many inflammatory cell adhesion responses including binding to…”
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Effect of alternative pathway therapy on branched chain amino acid metabolism in urea cycle disorder patients by Scaglia, Fernando, Carter, Susan, O’Brien, William E, Lee, Brendan

“…Urea cycle disorders (UCDs) are a group of inborn errors of hepatic metabolism caused by the loss of enzymatic activities that mediate the transfer of nitrogen…”
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Postpartum “Psychosis” in Mild Argininosuccinate Synthetase Deficiency by Enns, Gregory M., O'Brien, William E., Kobayashi, Keiko, Shinzawa, Haruhide, Pellegrino, Joan E.

“…Urea cycle disorders are relatively rare but well-established causes of postpartum coma and death. Such clinical presentations have been reported previously in…”
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Generation of a Mouse Model for Arginase II Deficiency by Targeted Disruption of the Arginase II Gene by Shi, Ou, Morris, Sidney M., Zoghbi, Huda, Porter, Carl W., O'Brien, William E.

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Arginase I expression and activity in human mononuclear cells after injury by OCHOA, Juan B, BERNARD, Andrew C, O'BRIEN, William E, GRIFFEN, Margaret M, MALEY, Mary E, ROCKICH, Anna K, TSUEI, Betty J, BOULANGER, Bernard R, KEAMEY, Paul A, MORRIS, Sidney M

“…To determine the effect of trauma on arginase, an arginine-metabolizing enzyme, in cells of the immune system in humans. Arginase, classically considered an…”
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Targeted Disruption of Mouse Long-Chain Acyl-CoA Dehydrogenase Gene Reveals Crucial Roles for Fatty Acid Oxidation by Kurtz, David M., Rinaldo, Piero, Rhead, William J., Tian, Liqun, Millington, David S., Vockley, Jerry, Hamm, Doug A., Brix, Amy E., Lindsey, J. Russell, Pinkert, Carl A., O'Brien, William E., Wood, Philip A.

“…Abnormalities of fatty acid metabolism are recognized to play a significant role in human disease, but the mechanisms remain poorly understood. Long-chain…”
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Perinatal Development of Endothelial Nitric Oxide Synthase-Deficient Mice by HEFLER, Lukas A, REYES, Christine A, O'BRIEN, William E, GREGG, Anthony R

“…The purpose of this study was to evaluate the influence of endothelial nitric oxide synthase (eNOS) deficiency on fetal growth, perinatal survival, and limb…”
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Long-Term Correction of Ornithine Transcarbamylase Deficiency by WPRE-Mediated Overexpression Using a Helper-Dependent Adenovirus by Mian, Asad, McCormack, Jr, W Michael, Mane, Viraj, Kleppe, Soledad, Ng, Philip, Finegold, Milton, O'Brien, William E, Rodgers, John R, Beaudet, Arthur L, Lee, Brendan

“…The urea cycle disorders (UCDs) are important models for developing gene replacement therapy for liver diseases. Long-term correction of the most common UCD,…”
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Isolation and characterization of a pyrophosphate-dependent phosphofructokinase from Propionibacterium shermanii by O'Brien, WE, Bowien, S, Wood, HG

“…A pyrophosphate-dependent phosphofructokinase (pyrophosphate; D-fructose-6-phosphate-1-phosphotransferase) has been purified and characterized from extracts of…”
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Analysis of guanidinoacetate and creatine by isotope dilution electrospray tandem mass spectrometry by Bodamer, Olaf A, Bloesch, Shannon M, Gregg, Anthony R, Stockler-Ipsiroglu, Silvia, O'Brien, William E

“…Guanidinoacetate methyltransferase (GAMT) deficiency is a disorder of creatine metabolism characterized by low plasma creatine concentrations in combination…”
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Creatine metabolism in combined methylmalonic aciduria and homocystinuria by Bodamer, Olaf A., Sahoo, Trilochan, Beaudet, Arthur L., O'Brien, William E., Bottiglieri, Teodoro, Stöckler-Ipsiroglu, Sylvia, Wagner, Conrad, Scaglia, Fernando

“…Methylation is an important aspect of many fundamental biological processes including creatine biosynthesis. We studied five patients with an inborn error of…”
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The role of endothelial nitric oxide synthase in the cerebral hemodynamics after controlled cortical impact injury in mice by Hlatky, Roman, Lui, Hao, Cherian, Leela, Goodman, J Clay, O'Brien, William E, Contant, Charles F, Robertson, Claudia S

“…Traumatic brain injury causes a reduction in cerebral blood flow, which may cause additional damage to the brain. The purpose of this study was to examine the…”
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Mutation Analysis for Heterozygote Detection and the Prenatal Diagnosis of Cystic Fibrosis by Lemna, Wanda K, Feldman, Gerald L, Kerem, Bat-sheva, Fernbach, Susan D, Zevkovich, Elaine P, O'Brien, William E, Riordan, John R, Collins, Francis S, Tsui, Lap-Chee, Beaudet, Arthur L

“…The cystic fibrosis gene was recently cloned, and a three-base deletion removing phenylalanine 508 from the coding region was identified as the mutation on the…”
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Homocysteine levels in A/J and C57BL/6J mice: genetic, diet, gender, and parental effects by Ernest, Sheila, Hosack, Angela, O'Brien, William E, Rosenblatt, David S, Nadeau, Joseph H

“…1 Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 2 Center for Computational Genomics and Systems Biology, Case…”
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The Nature of Shifting Cultivation: Stories of Harmony, Degradation, and Redemption by O'Brien, William E.

“…Shifting cultivation is identified as a major cause of tropical deforestation. Sources that recount such impacts routinely employ an Eden-lost narrative…”
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Endothelial-derived nitric oxide and angiotensinogen: blood pressure and metabolism during mouse pregnancy by Hefler, L A, Tempfer, C B, Moreno, R M, O'Brien, W E, Gregg, A R

“…The regulation of blood pressure during pregnancy involves several biological pathways. Candidate genes implicated in hypertensive diseases during pregnancy…”
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Molecular cloning and characterization of a murine LPS-inducible cDNA by Lee, CG, Demarquoy, J, Jackson, MJ, O'Brien, WE

“…Murine macrophages respond to endotoxins by inducing a vast array of genes that play a major role in the host's response to infection and tumor growth. We have…”
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