Search Results - "O'Brien, Patrick M"

Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure by PETERSON, J. Thomas, HALLAK, Hussein, JOHNSON, Linda, HUA LI, O'BRIEN, Patrick M, SLISKOVIC, Drago R, BOCAN, Thomas M. A, COKER, Mytsi L, ETOH, Takuma, SPINALE, Francis G

“…Matrix metalloproteinase (MMP) activation contributes to tissue remodeling in several disease states, and increased MMP activity has been observed in left…”
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Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis by SCHNUTE, Mark E, O'BRIEN, Patrick M, CARROLL, Jeffery N, PATT, William C, SHIEH, Huey S, COLLINS, Brandon, PAVLOVSKY, Alexander G, PALMQUIST, Katherine E, ASTON, Karl W, HITCHCOCK, Jeffrey, ROGERS, Michael D, MCDONALD, Joseph, NAHRA, Joe, JOHNSON, Adam R, MUNIE, Grace E, WITTWER, Arthur J, MAN, Chiu-Fai, SETTLE, Steven L, NEMIROVSKIY, Olga, VICKERY, Lillian E, AGAWAL, Arun, DYER, Richard D, SUNYER, Teresa, MORRIS, Mark, HOWARD ROARK, W, HANAU, Cathleen E, RUMINSKI, Peter G, SCHOLTEN, Jeffrey A, FLETCHER, Theresa R, HAMPER, Bruce C

“…Potent, highly selective and orally-bioavailable MMP-13 inhibitors have been identified based upon a (pyridin-4-yl)-2H-tetrazole scaffold. Co-crystal structure…”
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Structure−Activity Relationships and Pharmacokinetic Analysis for a Series of Potent, Systemically Available Biphenylsulfonamide Matrix Metalloproteinase Inhibitors by O'Brien, Patrick M, Ortwine, Daniel F, Pavlovsky, Alexander G, Picard, Joseph A, Sliskovic, Drago R, Roth, Bruce D, Dyer, Richard D, Johnson, Linda L, Man, Chiu Fai, Hallak, Hussein

“…A series of biphenylsulfonamide derivatives of (S)-2-(biphenyl-4-sulfonylamino)-3-methylbutyric acid (5) were prepared and evaluated for their ability to…”
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Transparency as a means to rebuild trust within the Church: a case study in how Catholic dioceses and eparchies in the United States have responded to the clergy sex abuse crisis by O’Brien, Patrick M.

“…The United States comprises 197 dioceses and eparchies. With the sexual abuse crisis affecting every one of those dioceses in some way, the clarion call from…”
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Subscapularis Function After Total Shoulder Arthroplasty Using Lesser Tuberosity Osteotomy or Tenotomy by OʼBrien, Patrick M, Kazanjian, Jack E, Kelly, 2nd, James D, Hobgood, E Rhett

“…Subscapularis dysfunction is a recognized complication after total shoulder arthroplasty (TSA). However, optimal subscapularis management during TSA is…”
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No association of sleep with total daily physical activity in normal sleepers by Youngstedt, Shawn D, Perlis, Michael L, O'Brien, Patrick M, Palmer, Christopher R, Smith, Michael T, Orff, Henry J, Kripke, Daniel F

“…The aim of two studies was to examine both between-subjects and within-subjects associations between daily amounts of physical activity and sleep in the home…”
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Emergency medicine and public health: New steps in old directions by Pollock, Daniel A., Lowery, Douglas W., O'Brien, Patrick M.

“…Emergency medicine and public health have opportunities to interact in at least 4 areas: surveillance of diseases, injuries, and health risks; monitoring…”
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Stereoselective binding of an enantiomeric pair of stromelysin-1 inhibitors caused by conformational entropy factors by Parker, Matthew H, Ortwine, Daniel F, O'Brien, Patrick M, Lunney, Elizabeth A, Banotai, Craig A, Mueller, William T, McConnell, Patrick, Brouillette, Christie G

“…Isothermal titration calorimetry was used to analyze the binding of an enantiomeric pair of inhibitors to the stromelysin-1 catalytic domain. Differences in…”
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Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation by Bocan, T M, Mazur, M J, Mueller, S B, Brown, E Q, Sliskovic, D R, O'Brien, P M, Creswell, M W, Lee, H, Uhlendorf, P D, Roth, B D

“…Atherosclerotic lesion development was assessed in the thoracic aorta and chronically denuded iliac-femoral artery of hypercholesterolemic New Zealand White…”
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Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. 17. Structure−Activity Relationships of Several Series of Compounds Derived from N-Chlorosulfonyl Isocyanate by Picard, Joseph A, O'Brien, Patrick M, Sliskovic, Drago R, Anderson, Maureen K, Bousley, Richard F, Hamelehle, Katherine L, Krause, Brian R, Stanfield, Richard L

“…Several series of acyl-CoA:cholesterol O-acyltransferase inhibitors were prepared by the stepwise addition of nitrogen, oxygen, and sulfur nucleophiles to…”
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Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase (ACAT) as Hypocholesterolemic Agents. 8. Incorporation of Amide or Amine Functionalities into a Series of Disubstituted Ureas and Carbamates. Effects on ACAT Inhibition in vitro and Efficacy in vivo by O'Brien, Patrick M, Sliskovic, Drago R, Blankley, C. John, Roth, Bruce. D, Wilson, Michael W, Hamelehle, Katherine L, Krause, Brian R, Stanfield, Richard L

“…A series of disubstituted ureas containing amide or amine groups was prepared and evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyl…”
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Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. Synthesis and Pharmacological Activity of (±)-2-Dodecyl-α-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5-acetamide and Structurally Related Tetrazole Amide Derivatives by O'Brien, Patrick M, Sliskovic, Drago R, Picard, Joseph A, Lee, Helen T, Purchase, Claude F, Roth, Bruce D, White, Andrew D, Anderson, Maureen, Mueller, Sandra Bak, Bocan, Thomas, Bousley, Richard, Hamelehle, Katherine L, Homan, Reynold, Lee, Peter, Krause, Brian R, Reindel, J. F, Turluck, Daniel

“…A series of tetrazole amide derivatives of (±)-2-dodecyl-α-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5-acetamide (1) was prepared and evaluated for their…”
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α-Substituted Malonester Amides:  Tools To Define the Relationship between ACAT Inhibition and Adrenal Toxicity by Sliskovic, Drago R, Picard, Joseph A, O'Brien, Patrick M, Liao, Peggy, Roark, W. Howard, Roth, Bruce D, Anderson, Maureen A, Mueller, Sandra Bak, Bocan, Thomas M. A, Bousley, Richard F, Hamelehle, Katherine L, Homan, Reynold, Reindel, James F, Stanfield, Richard L, Turluck, Daniel, Krause, Brian R

“…We prepared a series of α-substituted malonester amides that were evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyl transferase activity in…”
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REDUCTION REDUX: THE DALLAS BUDGET STORY, PART 2 by O'Brien, Patrick M

“…Return with me now to those halcyon days of FY1985-86 in Dallas, Texas, Sunbelt, U.S.A. The public library's budget had been increased by $1.5 million to $16.5…”
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Transparency as a means to rebuild trust within the Church: a case study in how Catholic dioceses and eparchies in the United States have responded to the clergy sex abuse crisis by O'Brien, Patrick M.

“…The United States comprises 197 dioceses and eparchies. With the sexual abuse crisis affecting every one of those dioceses in some way, the clarion call from…”
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The Sesame Land of General Semantics by O'Brien, Patrick M.

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Risk Factors for Early Failure of Surgical Amputations: An Analysis of 8,878 Isolated Lower Extremity Amputation Procedures by O'Brien, Patrick J., MD, Cox, Mitchell W., MD, FACS, Shortell, Cynthia K., MD, FACS, Scarborough, John E., MD, FACS

“…Background There are very few data currently published on risk factors for early failure of lower extremity amputation procedures. Study Design All patients…”
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Effect of bright light on cycling performance by O'BRIEN, P. M, O'CONNOR, P. J

“…The purpose of this study was to examine the effect of exposure to three levels of light intensity during cycling on average power output during an all-out…”
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Analysis of Infection Risk following Covered Stent Exclusion of Pseudoaneurysms in Prosthetic Arteriovenous Hemodialysis Access Grafts by Kim, Charles Y., MD, Guevara, Carlos J., MD, Engstrom, Bjorn I., MD, Gage, Shawn M., PA, O'Brien, Patrick J., MD, Miller, Michael J., MD, Suhocki, Paul V., MD, Lawson, Jeffrey H., MD, Smith, Tony P., MD

“…Abstract Purpose To determine whether exclusion of pseudoaneurysms with the use of a covered stent in prosthetic arteriovenous (AV) hemodialysis access grafts…”
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Multiple Choice by O'Brien, Patrick M, Bobick, Talya A

“…Smart companies have embraced the compelling business case for diversity. They welcome the infusion of new perspectives that can lead to previously…”
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