Search Results - "O'Brien, Nicole"

The Epidemiology of Vasospasm in Children With Moderate-to-Severe Traumatic Brain Injury by O’Brien, Nicole F, Maa, Tensing, Yeates, Keith O

“…OBJECTIVE:To gain a description of the prevalence and time course of vasospasm in children suffering moderate-to-severe traumatic brain injury. DESIGN:A…”
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Survey of resources available to implement severe pediatric traumatic brain injury management guidelines in low and middle-income countries by Wooldridge, Gavin, Hansmann, Andreas, Aziz, Omer, O’Brien, Nicole

“…Purpose Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, with a disproportionately high burden in low-middle income…”
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Non-invasive estimation of cerebral perfusion pressure using transcranial Doppler ultrasonography in children with severe traumatic brain injury by O’Brien, Nicole F, Lovett, Marlina E., Chung, Melissa, Maa, Tensing

“…Objective To identify if cerebral perfusion pressure (CPP) can be non-invasively estimated by either of two methods calculated using transcranial Doppler…”
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Adherence to severe malaria treatment guidelines in children at a Ugandan regional hospital: a baseline assessment for a malaria treatment quality improvement project by Moffitt, Cynthia A, Olupot-Olupot, Peter, Onen, Joan Wamulugwa, O'Brien, Nicole

“…Malaria is one of the most common causes of hospital admission and death in children under the age of five. The World Health Organization (WHO) has issued…”
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Multiple Organ Dysfunction Syndrome and Pediatric Logistic Organ Dysfunction–2 Score in Pediatric Cerebral Malaria by Johnson, Hunter, Raees, Madiha, Urbina, Evangelina, Muszynski, Jennifer, Seydel, Karl, Taylor, Terrie, O'Brien, Nicole

“…Malaria resulted in an estimated 627,000 deaths in 2020, the majority of which occurred in children under 5 years of age. Cerebral malaria (CM) is a severe…”
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Reference values for cerebral blood flow velocities in critically ill, sedated children by O’Brien, Nicole Fortier

“…Objective Transcranial Doppler ultrasound (TCD) is increasingly being used in the pediatric intensive care unit to assess cerebral hemodynamics during critical…”
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Noninvasive screening for intracranial hypertension in children with acute, severe traumatic brain injury by O'Brien, Nicole F, Maa, Tensing, Reuter-Rice, Karin

“…The aim of this study was to determine the relationship between transcranial Doppler (TCD) derived pulsatility index (PI), end diastolic flow velocity (Vd),…”
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Point-of-care Ultrasound to Assess Hemodynamic Contributors to Acute Kidney Injury in Pediatric Patients With Cerebral Malaria: A Pilot Study by Lintner Rivera, Michael, Prager, Ross, Gushu, Montfort Bernard, June, Sylvester, Phiri, Tusekile, Salameh, Jean-Paul, Johnson, Hunter C., Taylor, Terrie, O’Brien, Nicole F.

“…Acute kidney injury is common in severe malaria and is independently associated with mortality. The pathogenesis of acute kidney injury (AKI) in severe malaria…”
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DON in pediatric cerebral malaria, a phase I/IIA dose-escalation safety study: study protocol for a clinical trial by Nampota-Nkomba, Nginache, Nyirenda, Osward M, Mallewa, Jane, Chimalizeni, Yamikani, Dzabala, Nettie, Fay, Michael P, Gopalakrishnan, Mathangi, Laurens, Matthew B, O'Brien, Nicole F, Miller, Louis H, Pierce, Susan K, Riggle, Brittany A, Postels, Douglas G

“…Despite treatment with highly effective antimalarial drugs, malaria annually claims the lives of over half a million children under 5-years of age in…”
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Extracorporeal membrane oxygenation and cerebral blood flow velocity in children by O'Brien, Nicole F, Hall, Mark W

“…To determine how extracorporeal membrane oxygenation affects cerebral blood flow velocity and to determine whether specific changes in cerebral blood flow…”
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Admission Point-of-Care Testing for the Clinical Care of Children with Cerebral Malaria by Wichman, David, Guenther, Geoffrey, Simango, Nthambose M, Yu, Mengxin, Small, Dylan, Findorff, Olivia D, Amoah, Nathaniel O, Dasan, Rohini, Seydel, Karl B, Postels, Douglas G, O'Brien, Nicole F

“…Point-of-care testing (PoCT), an alternative to laboratory-based testing, may be useful in the clinical care of critically ill children in resource-limited…”
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Post hospital admission blood lactate measurements are associated with mortality but not neurologic morbidity in children with cerebral malaria by Olowojesiku, Ronke, Sherman, Meredith G, Mukadam, Amina M, Imam, Rami, Chastang, Kennedy M, Seydel, Karl B, Liomba, Alice M, Barber, John R, O'Brien, Nicole F, Postels, Douglas G

“…In children with cerebral malaria (CM) admission blood lactate has previously guided intravenous fluid therapy and been validated as a prognostic biomarker…”
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Optic nerve sheath diameter does not correlate with intracranial pressure in pediatric neurocritical care patients by Biggs, Austin, Lovett, Marlina, Moore-Clingenpeel, Melissa, O’Brien, Nicole

“…Purpose Intracranial pressure (ICP) > 20 mmHg is associated with worse outcomes in children. The gold standard for monitoring ICP is invasive, has…”
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Pediatric Acute Severe Neurologic Illness and Injury in an Urban and a Rural Hospital in the Democratic Republic of the Congo by Tshimangani, Taty, Pongo, Jean, Bodi Mabiala, Joseph, Yotebieng, Marcel, O'Brien, Nicole F

“…Empirical knowledge suggests that acute neurologic disorders are common in sub-Saharan Africa, but studies examining the true burden of these diseases in…”
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Detection of trends in flood magnitude and frequency in Canada by Mostofi Zadeh, Shabnam, Burn, Donald H., O’Brien, Nicole

“…•Peaks-over-threshold series were extracted for a large dataset of hydrometric stations using a semi-automated threshold selection method.•Trends in three…”
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Cerebrovascular Physiology During Pediatric Extracorporeal Membrane Oxygenation: A Multicenter Study Using Transcranial Doppler Ultrasonography by O'Brien, Nicole F, Buttram, Sandra D W, Maa, Tensing, Lovett, Marlina E, Reuter-Rice, Karin, LaRovere, Kerri L

“…To explore changes to expected, age-related transcranial Doppler ultrasound variables during pediatric extracorporeal membrane oxygenation. Prospective,…”
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Descriptive epidemiology of variants of infectious salmon anaemia virus in four Atlantic salmon farms in Newfoundland and Labrador, Canada by Romero, João F., Gardner, Ian A., Hammell, Larry, Groman, David, Whelan, Daryl, O’Brien, Nicole, Hawkins, Leighanne J., Burnley, Holly, Thakur, Krishna

“…An incursion of infectious salmon anaemia virus (ISAV) was detected in 2020 in southern Newfoundland, Canada. This resulted in an outbreak affecting four…”
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Capacity Building in Pediatric Critical Care-Global Health Research and Education: The Blantyre Experience by Raees, Madiha Q, Chimalizeni, Yamikani, Liomba, Alice W Muiruri, Pensulo, Paul, Gushu, Montfort Benard, Tebulo, Andrew, Malenga, Albert, Sikorski, Michael J, Holloway, Adrian J, Bhutta, Adnan T, Doctor, Allan, Remy, Kenneth E, O'Brien, Nicole F, Postels, Douglas G, Taylor, Terrie E

“…Pediatric critical care medicine (PCCM), as it is practiced in high-income countries, is focused on specialized medical care for the most vulnerable pediatric…”
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Mechanisms of Transcranial Doppler Ultrasound phenotypes in paediatric cerebral malaria remain elusive by O'Brien, Nicole F, Fonseca, Yudy, Johnson, Hunter C, Postels, Douglas, Birbeck, Gretchen L, Chimalizeni, Yamikani, Seydel, Karl B, Bernard Gushu, Montfort, Phiri, Tusekile, June, Sylvester, Chetcuti, Karen, Vidal, Lorenna, Goyal, Manu S, Taylor, Terrie E

“…Abstract Background Cerebral malaria (CM) results in significant paediatric death and neurodisability in sub-Saharan Africa. Several different alterations to…”
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Current Opinion and Use of Transcranial Doppler Ultrasonography in Traumatic Brain Injury in the Pediatric Intensive Care Unit by LaRovere, Kerri L, O'Brien, Nicole F, Tasker, Robert C

“…The purpose of this study was to identify and review clinical studies using transcranial Doppler (TCD) ultrasonography in children with severe traumatic brain…”
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