Search Results - "O'Brien, M Emmet"

The BLT1 Inhibitory Function of α-1 Antitrypsin Augmentation Therapy Disrupts Leukotriene B4 Neutrophil Signaling by O'Dwyer, Ciara A, O'Brien, M Emmet, Wormald, Mark R, White, Michelle M, Banville, Nessa, Hurley, Killian, McCarthy, Cormac, McElvaney, Noel G, Reeves, Emer P

“…Leukotriene B4 (LTB4) contributes to many inflammatory diseases, including genetic and nongenetic forms of chronic obstructive pulmonary disease. α-1…”
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Alpha-1 antitrypsin augmentation therapy corrects accelerated neutrophil apoptosis in deficient individuals by Hurley, Killian, Lacey, Noreen, O'Dwyer, Ciara A, Bergin, David A, McElvaney, Oliver J, O'Brien, M Emmet, McElvaney, Oisín F, Reeves, Emer P, McElvaney, Noel G

“…Alpha-1 antitrypsin (AAT) deficiency (AATD) is characterized by neutrophil-driven lung destruction and early emphysema in a low AAT, and high neutrophil…”
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Update on the combination effect of macrolide antibiotics in community-acquired pneumonia by Emmet O’Brien, M, Restrepo, Marcos I, Martin-Loeches, Ignacio

“…Abstract Community-acquired pneumonia (CAP) is a leading cause of death from an infectious cause worldwide. Guideline-concordant antibiotic therapy initiated…”
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The impact of smoke exposure on the clinical phenotype of alpha-1 antitrypsin deficiency in Ireland: exploiting a national registry to understand a rare disease by O'Brien, M Emmet, Pennycooke, Kevin, Carroll, Tomás P, Shum, Jonathan, Fee, Laura T, O'Connor, Catherine, Logan, P Mark, Reeves, Emer P, McElvaney, Noel G

“…Individuals with Alpha-1 antitrypsin deficiency (AATD) have mutations in the SERPINA1 gene causing genetic susceptibility to early onset lung and liver disease…”
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Increased Outer Arm and Core Fucose Residues on the N‑Glycans of Mutated Alpha‑1 Antitrypsin Protein from Alpha‑1 Antitrypsin Deficient Individuals by McCarthy, Cormac, Saldova, Radka, O’Brien, M. Emmet, Bergin, David A, Carroll, Tomás P, Keenan, Joanne, Meleady, Paula, Henry, Michael, Clynes, Martin, Rudd, Pauline M, Reeves, Emer P, McElvaney, Noel G

“…Alpha-1 antitrypsin (AAT) is the major physiological inhibitor of a range of serine proteases, and in the lung, it maintains a protease–antiprotease balance…”
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The effect of the decoy molecule PA401 on CXCL8 levels in bronchoalveolar lavage fluid of patients with cystic fibrosis by McElvaney, Oliver J., O’Reilly, Niamh, White, Michelle, Lacey, Noreen, Pohl, Kerstin, Gerlza, Tanja, Bergin, David A., Kerr, Hilary, McCarthy, Cormac, O’Brien, M. Emmet, Adage, Tiziana, Kungl, Andreas J., Reeves, Emer P., McElvaney, Noel G.

“…PA401 reduces levels of CXCL8 in cystic fibrosis airway samples thereby reducing neutrophil migration. (A) The chemokine CXCL8 is a key mediator of…”
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Intracystic papillary carcinoma in a male as a rare presentation of breast cancer: a case report and literature review by Romics, Jr, Laszlo, O'Brien, M Emmet, Relihan, Norma, O'Connell, Fionnuala, Redmond, H Paul

“…The term "intracystic papillary ductal carcinoma in situ" has recently changed and is now more appropriately referred to "intracystic papillary carcinoma"…”
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