Search Results - "O'Brien, Lee A"

A Comparison of Methods for Modeling Quantitative Structure−Activity Relationships by Sutherland, Jeffrey J, O'Brien, Lee A, Weaver, Donald F

“…A large number of methods are available for modeling quantitative structure−activity relationships (QSAR). We examine the predictive accuracy of several…”
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Treatment of sepsis-induced acquired protein C deficiency reverses Angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response by Richardson, Mark A, Gupta, Akanksha, O'Brien, Lee A, Berg, David T, Gerlitz, Bruce, Syed, Samreen, Sharma, Ganesh R, Cramer, Martin S, Heuer, Josef G, Galbreath, Elizabeth J, Grinnell, Brian W

“…The protein C (PC) pathway plays an important role in vascular and immune function, and acquired deficiency during sepsis is associated with increased…”
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Activated protein C and sepsis by O'Brien, Lee A, Gupta, Akanksha, Grinnell, Brian W

“…Protein C is a plasma protease that when activated plays a central role in modulating the function of the vascular endothelium and its interface with the…”
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Negative Regulation of Inducible Nitric-oxide Synthase Expression Mediated through Transforming Growth Factor-β-dependent Modulation of Transcription Factor TCF11 by Berg, David T., Gupta, Akanksha, Richardson, Mark A., O'Brien, Lee A., Calnek, David, Grinnell, Brian W.

“…Inducible nitric-oxide synthase (iNOS) plays a central role in the regulation of vascular function and response to injury. A central mediator controlling iNOS…”
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Activated Protein C Decreases Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand by an EPCR- Independent Mechanism Involving Egr-1/Erk-1/2 Activation by O’Brien, Lee A, Richardson, Mark A, Mehrbod, Sean F, Berg, David T, Gerlitz, Bruce, Gupta, Akanksha, Grinnell, Brian W

“…BACKGROUND—APC is an antithrombotic and antiinflammatory serine protease that plays an important role in vascular function. We report that APC can suppress the…”
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The role of the FcGRIIIa polymorphism in modifying the association between treatment and outcome in patients with rheumatoid arthritis treated with rituximab versus TNF-α antagonist therapies by Sarsour, Khaled, Greenberg, Jeffrey, Johnston, Joseph A, Nelson, David R, O'Brien, Lee A, Oddoux, Carole, Ostrer, Harry, Pearlman, Alex, Reed, George

“…There is an association between the FcGRIIIa polymorphism and the development of rheumatoid arthritis (RA). Studies in non-Hodgkin lymphoma demonstrated a…”
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Circulating endothelial and endothelial progenitor cells in patients with severe sepsis by Schlichting, Douglas E., Waxman, Aaron B., O'Brien, Lee A., Wang, Tiffany, Naum, Chris C., Rubeiz, George J., Um, Suzane L., Williams, Mark, Betty Yan, Sau-Chi

“…Elevated circulating endothelial cell (CEC) and circulating endothelial progenitor cell (CEPC) counts may indicate vascular damage and disease status, but data…”
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Spline-Fitting with a Genetic Algorithm:  A Method for Developing Classification Structure−Activity Relationships by Sutherland, Jeffrey J, O'Brien, Lee A, Weaver, Donald F

“…Classification methods allow for the development of structure−activity relationship models when the target property is categorical rather than continuous. We…”
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ADAMTS13 cleavage efficiency is altered by mutagenic and, to a lesser extent, polymorphic sequence changes in the A1 and A2 domains of von Willebrand factor by Pruss, Cynthia M., Notley, Colleen R. P., Hegadorn, Carol A., O’Brien, Lee A., Lillicrap, David

“…Summary The multimeric plasma protein von Willebrand factor (VWF) is regulated in size by its protease, ADAMTS13 (a disintegrin and metalloproteinase with…”
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Founder von Willebrand factor haplotype associated with type 1 von Willebrand disease by O'Brien, Lee A., James, Paula D., Othman, Maha, Berber, Ergul, Cameron, Cherie, Notley, ColleenR.P., Hegadorn, Carol A., Sutherland, Jeffrey J., Hough, Christine, Rivard, Georges E., O'Shaunessey, Denise, Lillicrap, David

“…To date, no dominant mutation has been identified in a significant proportion of patients with type 1 von Willebrand disease (VWD). In this study, we examined…”
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The Puzzling Role of TRAIL in Endothelial Cell Biology by OʼBrien, Lee A, Richardson, Mark A, Berg, David T, Gerlitz, Bruce, Gupta, Akanksha, Grinnell, Brian W

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Molecular modeling of the von Willebrand factor A2 Domain and the effects of associated type 2A von Willebrand disease mutations by Sutherland, Jeffrey J, O'Brien, Lee A, Lillicrap, David, Weaver, Donald F

“…A homology model for the A2 domain of von Willebrand factor (VWF) is presented. A large number of target-template alignments were combined into a consensus…”
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A novel type 2A von Willebrand factor mutation located at the last nucleotide of exon 26 (3538G>A) causes skipping of 2 nonadjacent exons by James, Paula D., O'Brien, Lee A., Hegadorn, Carol A., Notley, Colleen R.P., Sinclair, Gary D., Hough, Christine, Poon, Man-Chiu, Lillicrap, David

“…In this manuscript, we describe a case of type 2A von Willebrand disease (VWD) caused by the novel heterozygous G>A transition at nucleotide 3538, which should…”
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Pruned Receptor Surface Models and Pharmacophores for Three-Dimensional Database Searching by Sutherland, Jeffrey J, O'Brien, Lee A, Weaver, Donald F

“…A pharmacophore represents the 3D arrangement of chemical features that are shared by molecules exhibiting activity at a protein receptor. Pharmacophores are…”
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Glycosaminoglycans Bind Factor Xa in a Ca2+-Dependent Fashion and Modulate Its Catalytic Activity by O'Brien, Lee A, Stafford, Alan R, Fredenburgh, James C, Weitz, Jeffrey I

“…Recent studies have demonstrated the existence of a Ca2+-dependent heparin-binding site on factor Xa. To characterize this heparin-binding site, the extrinsic…”
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Abstract 1738: Assay development for detecting cMET expression in circulating tumor cells (CTC), a potential patient tailoring marker for evaluation of cMET inhibitors by Yan, S Betty, Um, Suzane L., Peek, Victoria L., Yan, Lei, Zeng, Wei, Liu, Ling L., Brandt, John T., Kadam, Sunil, O'Brien, Lee A., Walgren, Richard A.

“…Abstract Hepatocyte growth factor and its receptor c-MET have been implicated in tumor formation and progression as well as drug treatment resistance to…”
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Negative Regulation of Inducible Nitric-oxide Synthase Expression Mediated through Transforming Growth Factor-β-dependent Modulation of Transcription Factor TCF11 by David T. Berg, Akanksha Gupta, Mark A. Richardson, Lee A. O'Brien, David Calnek, Brian W. Grinnell

“…Inducible nitric-oxide synthase (iNOS) plays a central role in the regulation of vascular function and response to injury. A central mediator controlling iNOS…”
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Glycosaminoglycans Bind Factor Xa in a Ca 2+ -Dependent Fashion and Modulate Its Catalytic Activity by O'Brien, Lee A., Stafford, Alan R., Fredenburgh, James C., Weitz, Jeffrey I.

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