Search Results - "O'Brien, G. S."

Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia by Hochhaus, A, O'Brien, S G, Guilhot, F, Druker, B J, Branford, S, Foroni, L, Goldman, J M, Müller, M C, Radich, J P, Rudoltz, M, Mone, M, Gathmann, I, Hughes, T P, Larson, R A

“…Imatinib mesylate is considered standard of care for first-line treatment of chronic phase chronic myeloid leukemia (CML-CP). In the phase III, randomized,…”
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Time reverse location of seismic long-period events recorded on Mt Etna by O'Brien, G. S., Lokmer, I., De Barros, L., Bean, C. J., Saccorotti, G., Metaxian, J.-P., Patane, D.

“…Summary We present the first application of a time reverse location method in a volcanic setting, for a family of long-period (LP) events recorded on Mt Etna…”
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Effects of imatinib mesylate (ST1571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome P450 3A4 substrate, in patients with chronic myeloid leukaemia by O'BRIEN, S. G, MEINHARDT, P, FISCHER, T, BOND, E, BECK, J, PENG, B, DUTREIX, C, MEHRING, G, MILOSAVLJEV, S, HUBER, C, CAPDEVILLE, R

“…The inhibition by imatinib of the cytochrome p450 3A4 isoenzyme may reduce the CYP3A4-mediated metabolic clearance of clinically important coadministered…”
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Discrete visco-elastic lattice methods for seismic wave propagation by G. S. O'Brien

“…2D and 3D discrete particle or lattice methods for the simulation of seismic waves are presented for different visco‐elastic media. It is demonstrated that a…”
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Analysis of dynamics of vulcanian activity of Ubinas volcano, using multicomponent seismic antennas by Inza, L.A., Métaxian, J.P., Mars, J.I., Bean, C.J., O'Brien, G.S., Macedo, O., Zandomeneghi, D.

“…A series of 16 vulcanian explosions occurred at Ubinas volcano between May 24 and June 14, 2009. The intervals between explosions were from 2.1h to more than…”
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Statistical selection of the "best" seismic source mechanisms from inversions of synthetic volcanic long-period events by O'Brien, G. S., Lokmer, I., Bean, C. J.

“…Inversions for the source mechanism of long‐period (LP) seismicity recorded on volcanoes have become increasingly common and are used to interpret fluid‐driven…”
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A 2D channel-clogging biofilm model by Winstanley, H. F., Chapwanya, M., Fowler, A. C., O’Brien, S. B. G.

“…We present a model of biofilm growth in a long channel where the biomass is assumed to have the rheology of a viscous polymer solution. We examine the…”
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Seismicity on volcanoes generated by gas slug ascent by O'Brien, G. S., Bean, C. J.

“…Very long period (VLP) signals provide a unique insight into the source process of seismic signals recorded on active or restless volcanoes. This is due to the…”
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Seismo‐volcano source localization with triaxial broad‐band seismic array by Inza, L. A., Mars, J. I., Métaxian, J. P., O’Brien, G. S., Macedo, O.

“…SUMMARY Seismo‐volcano source localization is essential to improve our understanding of eruptive dynamics and of magmatic systems. The lack of clear seismic…”
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On the formation of fold-type oscillation marks in the continuous casting of steel by Vynnycky, M., Saleem, S., Devine, K. M., Florio, B. J., Mitchell, S. L., O’Brien, S. B. G.

“…Asymptotic methods are employed to revisit an earlier model for oscillation-mark formation in the continuous casting of steel. A systematic…”
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On the use of lonafarnib in myelodysplastic syndrome and chronic myelomonocytic leukemia by Feldman, E J, Cortes, J, DeAngelo, D J, Holyoake, T, Simonsson, B, O'Brien, S G, Reiffers, J, Turner, A R, Roboz, G J, Lipton, J H, Maloisel, F, Colombat, P, Martinelli, G, Nielsen, J L, Petersdorf, S, Guilhot, F, Barker, J, Kirschmeier, P, Frank, E, Statkevich, P, Zhu, Y, Loechner, S, List, A

“…Lonafarnib is an orally bio-available farnesyltransferase inhibitor that prevents farnesylation of specific target proteins including Ras. In a multicenter…”
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Common image gather conditioning using cycle generative adversarial networks by O'Brien, G.S.

“…ABSTRACT Seismically derived amplitude‐versus‐angle attributes along with well constraints are the base inputs into inverting seismic into subsurface…”
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Moment tensor inversion of explosive long period events recorded on Arenal volcano, Costa Rica, constrained by synthetic tests by Davi, R., O'Brien, G.S., Lokmer, I., Bean, C.J., Lesage, P., Mora, M.M.

“…In order to constrain the moment tensor solution of an explosive seismic event recorded on Arenal volcano, Costa Rica, we perform tests using synthetic data…”
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Prognostic factors for patients with chronic myeloid leukaemia in chronic phase treated with imatinib mesylate after failure of interferon alfa by MARIN, D, MARKTEL, S, LENNARD, A, NEYLON, A, O'BRIEN, S. G, GOLDMAN, J. M, APPERLEY, J. F, BUA, M, SZYDLO, R. M, FRANCESCHINO, A, NATHAN, I, FOOT, N, CRAWLEY, C, NAKORN, T. Na, OLAVARRIA, E

“…We assessed clinical results in 145 patients with chronic myeloid leukaemia in chronic phase who satisfied criteria for interferon-alpha failure and were thus…”
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Sinking bubbles in stout beers by Lee, W. T., Kaar, S., O'Brien, S. B. G.

“…A surprising phenomenon witnessed by many is the sinking bubbles seen in a settling pint of stout beer. Bubbles are less dense than the surrounding fluid so…”
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A discrete numerical method for modeling volcanic earthquake source mechanisms by O'Brien, G. S., Bean, C. J.

“…We propose a new numerical method for the mechanical coupling of the deformation of a fluid‐rock system. The method is based on coupling the lattice…”
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On the interactive effects of mould taper and superheat on air gaps in continuous casting by Florio, B. J., Vynnycky, M., Mitchell, S. L., O’Brien, S. B. G.

“…The formation of an air gap in continuous casting systems is detrimental to the process efficiency as it acts to thermally insulate the cast from the…”
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Modelling fluid induced seismicity on a nearby active fault by Murphy, S., O'Brien, G. S., McCloskey, J., Bean, C. J., Nalbant, S.

“…We present a numerical investigation of the effect that static stress perturbations due to fluid injection have on a nearby active fault where the fluid does…”
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Pre‐stack Kirchhoff depth migration local space‐shift imaging condition: synthetic and data examples by O'Brien, G.S., Delaney, S.J., Igoe, M.

“…ABSTRACT Extracting accurate common image angle gathers from pre‐stack depth migrations is important in the generation of any incremental uplift to the…”
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A single nucleotide polymorphism in the coding region of ABL and its effects on sensitivity to imatinib by CROSSMAN, L. C, O'HARE, T, DEININGER, M. W. N, LANGE, T, WILLIS, S. G, STOFFREGEN, E. P, CORBIN, A. S, O'BRIEN, S. G, HEINRICH, M. C, DRUKER, B. J, MIDDLETON, P. G

“…We have identified a gene polymorphism (K247R) within or close to the P-loop of BCR-ABL, which leads to the substitution of arginine for lysine. We…”
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