Search Results - "O'Briant, K C"

Evidence for genetic heterogeneity in hereditary neuralgic amyotrophy by WATTS, G. D. J, O'BRIANT, K. C, BORRESON, T. E, WINDEBANK, A. J, CHANCE, P. F

“…Hereditary neuralgic amyotrophy (HNA) is a rare autosomal dominant disorder characterized by recurrent episodes of severe arm and shoulder pain with weakness,…”
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A 1.4-Mb High-Resolution Physical Map and Contig of Chromosome Segment 11p15.5 and Genes in the LOH11A Metastasis Suppressor Region by Bepler, Gerold, O'Briant, Kathy C., Kim, Young-Chul, Schreiber, Gilbert, Pitterle, Diana M.

“…The centromeric part of chromosome segment 11p15.5 contains a region of frequent allele loss in many adult solid malignancies. This region, called LOH11A, is…”
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Relative cytotoxic activity of immunotoxins reactive with different epitopes on the extracellular domain of the c‐erbB‐2 (HER‐2/neu) gene product p185 by Boyer, Cinda M., Pusztai, Lajos, Wiener, Jon R., Xu, Feng Ji, Dean, G. Scott, Bast, Blanche S., O'Briant, Kathy C., Greenwald, Marilee, DeSombre, Karen A., Bast, Robert C.

“…Different epitopes on the extracellular domain of the HER‐2 receptor can serve as distinct targets for immunotoxins. To determine the optimal epitope target…”
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Rater agreement and utility of the mutagen-induced chromosome damage assay by McIntyre, L M, O'Briant, K C, McBride, C M, Bepler, G

“…Chromosomal damage in peripheral blood lymphocytes induced by short-term in vitro exposure to the cytotoxic antibiotic bleomycin was first described in 1983…”
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A rare polyadenylation signal mutation of the FOXP3 gene (AAUAAA-->AAUGAA) leads to the IPEX syndrome by Bennett, C L, Brunkow, M E, Ramsdell, F, O'Briant, K C, Zhu, Q, Fuleihan, R L, Shigeoka, A O, Ochs, H D, Chance, P F

“…The mouse scurfy gene, Foxp3, and its human orthologue, FOXP3, which maps to Xp11.23-Xq13.3, were recently identified by positional cloning. Point mutations…”
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The effect of antibodies and immunotoxins reactive with HER-2/neu on growth of ovarian and breast cancer cell lines by Rodríguez, G C, Boente, M P, Berchuck, A, Whitaker, R S, O'Briant, K C, Xu, F, Bast, Jr, R C

“…Because HER-2/neu is overexpressed in one third of breast and ovarian cancers, we examined the effect of unconjugated monoclonal antibodies (ID-5, PB-3, TA-1)…”
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Alkylating agents and immunotoxins exert synergistic cytotoxic activity against ovarian cancer cells : mechanism of action by LIDOR, Y. J, O'BRIANT, K. C, XU, F. J, HAMILTON, T. C, OZOLS, R. F, BAST, R. C

“…Alkylating agents can be administered in high dosage to patients with ovarian cancer using autologous bone marrow support, but drug-resistant tumor cells can…”
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Association of chromosome 11 locus D11S12 with histology, stage, and metastases in lung cancer by Bepler, G, Fong, K M, Johnson, B E, O'Briant, K C, Daly, L A, Zimmerman, P V, Garcia-Blanco, M A, Peterson, B

“…We have reported frequent allele loss for the marker D11S12 on chromosome band 11p15.5 in human lung cancer. The smallest common region of allele loss has been…”
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Lung cancer and the human gene for ribonucleotide reductase subunit M1 (RRM1) by Pitterle, D M, Kim, Y C, Jolicoeur, E M, Cao, Y, O'Briant, K C, Bepler, G

“…LOH11A is a region of Chromosome (Chr) 11p15.5 where 75% of lung cancers show loss of heterozygosity (LOH). Clinical and cell biological studies suggest that…”
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Evidence of a founder effect and refinement of the hereditary neuralgic amyotrophy (HNA) locus on 17q25 in American families by WATTS, Giles D. J, O'BRIANT, Kathy C, CHANCE, Phillip F

“…Hereditary neuralgic amyotrophy (HNA) is an autosomal dominant disorder that is associated with episodic recurrent brachial plexus neuropathy. A mutation for…”
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SSA/RO52 gene and expressed sequence tags in an 85 kb region of chromosome segment 11p15.5 by KIM, Y.-C, CAO, Y, PITTERLE, D. M, O'BRIANT, K. C, BEPLER, G

“…Frequent allelic loss in lung cancer has been described in a region on chromosome segment 11p15.5 (LOH11A). The region is approximately 650 kb in size and…”
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Potential Role of HE4 in Multimodal Screening for Epithelial Ovarian Cancer by Urban, Nicole, Thorpe, Jason D., Bergan, Lindsay A., Forrest, Robin M., Kampani, Archana V., Scholler, Nathalie, O'Briant, Kathy C., Anderson, Garnet L., Cramer, Daniel W., Berg, Christine D., McIntosh, Martin W., Hartge, Patricia, Drescher, Charles W.

“…In screening for epithelial ovarian cancer, unnecessary surgery can be reduced by limiting use of transvaginal ultrasound (TVU) to women with increasing CA125…”
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Smoking, gender, and survival association with allele loss for the LOH11B lung cancer region on chromosome 11 by Schreiber, G, Fong, K M, Peterson, B, Johnson, B E, O'Briant, K C, Bepler, G

“…We have reported frequent allele loss for the marker HRAS on chromosome 11p in human lung cancer and defined the smallest common region of deletion (designated…”
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An 84-kilobase physical map and repeat polymorphisms of the gastrin/cholecystokinin brain receptor region at the junction of chromosome segments 11p15.4 and 15.5 by O'Briant, K C, Ali, S Y, Weier, H U, Bepler, G

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Elimination of clonogenic breast cancer cells from human bone marrow. A comparison of immunotoxin treatment with chemoimmunoseparation using 4-hydroperoxycyclophosphamide, monoclonal antibodies, and magnetic microspheres by O'Briant, K C, Shpall, E J, Houston, L L, Peters, W P, Bast, Jr, R C

“…Autologous bone marrow transplantation (ABMT) may aid in the management of breast cancer, but is currently limited to patients without bone marrow metastases…”
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Bead-Based ELISA for Validation of Ovarian Cancer Early Detection Markers by SCHOLLER, Nathalie, CRAWFORD, Meghan, SATO, Alicia, DRESCHER, Charles W, O'BRIANT, Kathy C, KIVIAT, Nancy, ANDERSON, Garnet L, URBAN, Nicole

“…Purpose: Efforts to validate ovarian cancer early detection biomarkers with immunoassays are challenged by the limited specimen volumes available. We sought to…”
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Delineation of the centromeric and telomeric chromosome segment 11p15.5 lung cancer suppressor regions LOH11A and LOH11B by O'Briant, Kathy C., Bepler, Gerold

“…We have reported frequent allele loss for two separate regions identified by the markers D11S12 and HRAS on chromosome 11p15.5. D11S12 allele loss was…”
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SSA/RO52gene and expressed sequence tags in an 85 kb region of chromosome segment 11p15.5 by Kim, Young‐Chul, Cao, Youjia, Pitterle, Diana M., O'Briant, Kathy C., Bepler, Gerold

“…Frequent allelic loss in lung cancer has been described in a region on chromosome segment 11p15.5 (LOH11A). The region is approximately 650 kb in size and…”
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Relative cytotoxic activity of immunotoxins reactive with different epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene product p185 by Boyer, C M, Pusztai, L, Wiener, J R, Xu, F J, Dean, G S, Bast, B S, O'Briant, K C, Greenwald, M, DeSombre, KA, Bast, RC Jr

“…Different epitopes on the extracellular domain of the HER-2 receptor can serve as distinct targets for immunotoxins. To determine the optimal epitope target…”
Get full text