Search Results - "O'BYRNE, K"

Afatinib versus gefitinib in patients with EGFR mutation-positive advanced non-small-cell lung cancer: overall survival data from the phase IIb LUX-Lung 7 trial by Paz-Ares, L., Tan, E.-H., O’Byrne, K., Zhang, L., Hirsh, V., Boyer, M., Yang, J.C.-H., Mok, T., Lee, K.H., Lu, S., Shi, Y., Lee, D.H., Laskin, J., Kim, D.-W., Laurie, S.A., Kölbeck, K., Fan, J., Dodd, N., Märten, A., Park, K.

“…In LUX-Lung 7, the irreversible ErbB family blocker, afatinib, significantly improved progression-free survival (PFS), time-to-treatment failure (TTF) and…”
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Poor patient outcome correlates with active engulfment of cytokeratin positive CTCs within cancer-associated monocyte population in lung cancer by Wiegmans, A. P., Ivanova, E., Naei, V. Y., Monkman, J., Fletcher, J., Mullally, W., Warkiani, M. E., O’Byrne, K., Kulasinghe, A.

“…High rates of mortality in non-small cell lung cancer lung cancer is due to inherent and acquired resistance to systemic therapies and subsequent metastatic…”
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Chronic immune activation and inflammation as the cause of malignancy by O'BYRNE, K. J, DALGLEISH, A. G

“…Several chronic infections known to be associated with malignancy have established oncogenic properties. However the existence of chronic inflammatory…”
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Kisspeptin neurones in the posterodorsal medial amygdala modulate sexual partner preference and anxiety in male mice by Adekunbi, D. A., Li, X. F., Lass, G., Shetty, K., Adegoke, O. A., Yeo, S. H., Colledge, W. H., Lightman, S. L., O'Byrne, K. T.

“…The posterodorsal medial amygdala (MePD) is a neural site in the limbic brain involved in regulating emotional and sexual behaviours. There is, however,…”
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Relative Importance of the Arcuate and Anteroventral Periventricular Kisspeptin Neurons in Control of Puberty and Reproductive Function in Female Rats by Hu, M. H, Li, X. F, McCausland, B, Li, S. Y, Gresham, R, Kinsey-Jones, J. S, Gardiner, J. V, Sam, A. H, Bloom, S. R, Poston, L, Lightman, S. L, Murphy, K. G, O'Byrne, K. T

“…Kisspeptin plays a critical role in pubertal timing and reproductive function. In rodents, kisspeptin perikarya within the hypothalamic arcuate (ARC) and…”
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Effect of dose adjustment on the safety and efficacy of afatinib for EGFR mutation-positive lung adenocarcinoma: post hoc analyses of the randomized LUX-Lung 3 and 6 trials by Yang, J.C.-H., Sequist, L.V., Zhou, C., Schuler, M., Geater, S.L., Mok, T., Hu, C.-P., Yamamoto, N., Feng, J., O'Byrne, K., Lu, S., Hirsh, V., Huang, Y., Sebastian, M., Okamoto, I., Dickgreber, N., Shah, R., Märten, A., Massey, D., Wind, S., Wu, Y.-L.

“…Afatinib 40mg/day is approved for first-line treatment of EGFR mutation-positive non-small-cell lung cancer (NSCLC). In the case of drug-related grade ≥3 or…”
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Bone matters in lung cancer by Brodowicz, T., O'Byrne, K., Manegold, C.

“…Bone metastases are a significant and undertreated clinical problem in patients with advanced lung cancer. We reviewed the incidence of bone metastases and…”
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Second ESMO consensus conference on lung cancer: pathology and molecular biomarkers for non-small-cell lung cancer by Kerr, K.M., Bubendorf, L., Edelman, M.J., Marchetti, A., Mok, T., Novello, S., O'Byrne, K., Stahel, R., Peters, S., Felip, E., Stahel, Rolf, Felip, Enriqueta, Peters, Solange, Kerr, Keith, Besse, Benjamin, Vansteenkiste, Johan, Eberhardt, Wilfried, Edelman, Martin, Mok, Tony, O'Byrne, Ken, Novello, Silvia, Bubendorf, Lukas, Marchetti, Antonio, Baas, Paul, Reck, Martin, Syrigos, Konstantinos, Paz-Ares, Luis, Smit, Egbert F., Meldgaard, Peter, Adjei, Alex, Nicolson, Marianne, Crinò, Lucio, Van Schil, Paul, Senan, Suresh, Faivre-Finn, Corinne, Rocco, Gaetano, Veronesi, Giulia, Douillard, Jean-Yves, Lim, Eric, Dooms, Christophe, Weder, Walter, De Ruysscher, Dirk, Le Pechoux, Cecile, De Leyn, Paul, Westeel, Virginie

“…To complement the existing treatment guidelines for all tumour types, ESMO organises consensus conferences to focus on specific issues in each type of tumour…”
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The Posterodorsal Medial Amygdala Regulates the Timing of Puberty Onset in Female Rats by Li, X. F, Hu, M. H, Hanley, B. P, Lin, Y. S, Poston, L, Lightman, S. L, O'Byrne, K. T

“…Obesity is the major risk factor for early puberty, but emerging evidence indicates other factors including psychosocial stress. One key brain region notable…”
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Suppression of the GnRH Pulse Generator by Neurokinin B Involves a κ-Opioid Receptor-Dependent Mechanism by Grachev, P, Li, X. F, Kinsey-Jones, J. S, di Domenico, A. L, Millar, R. P, Lightman, S. L, O'Byrne, K. T

“…Neurokinin B (NKB) and its receptor (NK3R) are coexpressed with kisspeptin, Dynorphin A (Dyn), and their receptors [G-protein-coupled receptor-54 (GPR54)] and…”
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Randomized phase II study of cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone as first-line therapy in EGFR-expressing advanced non-small-cell lung cancer by Rosell, R., Robinet, G., Szczesna, A., Ramlau, R., Constenla, M., Mennecier, B. C., Pfeifer, W., O'Byrne, K. J., Welte, T., Kolb, R., Pirker, R., Chemaissani, A., Perol, M., Ranson, M. R., Ellis, P. A., Pilz, K., Reck, M.

“…Background: The Lung Cancer Cetuximab Study is an open-label, randomized phase II pilot study of cisplatin and vinorelbine combined with the epidermal growth…”
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Overexpression of the mammalian target of rapamycin (mTOR) and angioinvasion are poor prognostic factors in early stage NSCLC: A verification study by Gately, K, Al-Alao, B, T.Dhillon, Mauri, F, Cuffe, S, Seckl, M, O’Byrne, K

“…Abstract Background A recent study by Dhillon et al. [12] , identified both angioinvasion and mTOR as prognostic biomarkers for poor survival in early stage…”
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Dacomitinib versus erlotinib in patients with EGFR-mutated advanced nonsmall-cell lung cancer (NSCLC): pooled subset analyses from two randomized trials by Ramalingam, S.S., O'Byrne, K., Boyer, M., Mok, T., Jänne, P.A., Zhang, H., Liang, J., Taylor, I., Sbar, E.I., Paz-Ares, L.

“…The irreversible epidermal growth factor receptor (EGFR) inhibitors have demonstrated efficacy in NSCLC patients with activating EGFR mutations, but it is…”
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Long-term survival with first-line nivolumab plus ipilimumab in patients with advanced non-small-cell lung cancer: a pooled analysis by Borghaei, H., Ciuleanu, T.-E., Lee, J.-S., Pluzanski, A., Caro, R. Bernabe, Gutierrez, M., Ohe, Y., Nishio, M., Goldman, J., Ready, N., Spigel, D.R., Ramalingam, S.S., Paz-Ares, L.G., Gainor, J.F., Ahmed, S., Reck, M., Maio, M., O’Byrne, K.J., Memaj, A., Nathan, F., Tran, P., Hellmann, M.D., Brahmer, J.R.

“…First-line nivolumab plus ipilimumab prolongs survival versus chemotherapy in advanced non-small-cell lung cancer (NSCLC). We further characterized clinical…”
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The role of neurokinin B signalling in reproductive neuroendocrinology by Grachev, P, Millar, R P, O'Byrne, K T

“…The KNDy neuropeptides, kisspeptin, neurokinin B (NKB) and dynorphin A (Dyn), have been implicated in regulating pulsatile luteinising hormone (LH) secretion…”
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Kisspeptin stimulation of insulin secretion: mechanisms of action in mouse islets and rats by Bowe, J. E., King, A. J., Kinsey-Jones, J. S., Foot, V. L., Li, X. F., O’Byrne, K. T., Persaud, S. J., Jones, P. M.

“…Aims/hypothesis Kisspeptin is a novel peptide identified as an endogenous ligand of the G-protein-coupled receptor 54 (GPR-54), which plays a crucial role in…”
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Down-Regulation of Hypothalamic Kisspeptin and its Receptor, Kiss1r, mRNA Expression is Associated with Stress-Induced Suppression of Luteinising Hormone Secretion in the Female Rat by Kinsey-Jones, J. S., Li, X. F., Knox, A. M. I., Wilkinson, E. S., Zhu, X. L., Chaudhary, A. A., Milligan, S. R., Lightman, S. L., O'Byrne, K. T.

“…Identification of kisspeptin (Kiss1) and its G protein‐coupled receptor 54 (Kiss1r) as an essential component of the hypothalamic‐pituitary‐gonadal (HPG) axis…”
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Neonatal Lipopolysaccharide Exposure Delays Puberty and Alters Hypothalamic Kiss1 and Kiss1r mRNA Expression in the Female Rat by Knox, A. M. I., Li, X. F., Kinsey-Jones, J. S., Wilkinson, E. S., Wu, X. Q., Cheng, Y.S., Milligan, S. R., Lightman, S. L., O'Byrne, K. T.

“…Immunological challenge experienced in early life can have long‐term programming effects on the hypothalamic‐pituitary‐adrenal axis that permanently influence…”
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Cilengitide combined with cetuximab and platinum-based chemotherapy as first-line treatment in advanced non-small-cell lung cancer (NSCLC) patients: results of an open-label, randomized, controlled phase II study (CERTO) by Vansteenkiste, J., Barlesi, F., Waller, C.F., Bennouna, J., Gridelli, C., Goekkurt, E., Verhoeven, D., Szczesna, A., Feurer, M., Milanowski, J., Germonpre, P., Lena, H., Atanackovic, D., Krzakowski, M., Hicking, C., Straub, J., Picard, M., Schuette, W., O'Byrne, K.

“…This multicentre, open-label, randomized, controlled phase II study evaluated cilengitide in combination with cetuximab and platinum-based chemotherapy,…”
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Neonatal Lipopolysaccharide Exposure Exacerbates Stress-Induced Suppression of Luteinizing Hormone Pulse Frequency in Adulthood by Li, X. F, Kinsey-Jones, J. S, Knox, A. M. I, Wu, X. Q, Tahsinsoy, D, Brain, S. D, Lightman, S. L, O’Byrne, K. T

“…Early life exposure to immunological challenge has programming effects on the adult hypothalamo-pituitary-adrenocortical axis stress responsivity, and stress…”
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