Search Results - "O'BRIEN, Deborah A"

Phosphoglycerate Kinase 2 (PGK2) Is Essential for Sperm Function and Male Fertility in Mice by Danshina, Polina V, Geyer, Christopher B, Dai, Qunsheng, Goulding, Eugenia H, Willis, William D, Kitto, G. Barrie, McCarrey, John R, Eddy, E.M, O'Brien, Deborah A

“…Phosphoglycerate kinase 2 (PGK2), an isozyme that catalyzes the first ATP-generating step in the glycolytic pathway, is encoded by an autosomal retrogene that…”
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Glyceraldehyde 3-Phosphate Dehydrogenase-S, a Sperm-Specific Glycolytic Enzyme, Is Required for Sperm Motility and Male Fertility by Miki, Kiyoshi, Qu, Weidong, Goulding, Eugenia H., Willis, William D., Bunch, Donna O., Strader, Lillian F., Perreault, Sally D., Eddy, Edward M., O'Brien, Deborah A., Yanagimachi, Ryuzo

“…Although glycolysis is highly conserved, it is remarkable that several unique isozymes in this central metabolic pathway are found in mammalian sperm…”
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Multiple Glycolytic Enzymes Are Tightly Bound to the Fibrous Sheath of Mouse Spermatozoa by KRISFALUSI, Michelle, MIKI, Kiyoshi, MAGYAR, Patricia L, O'BRIEN, Deborah A

“…The fibrous sheath is a cytoskeletal structure located in the principal piece of mammalian sperm flagella. Previous studies showed that glyceraldehyde…”
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Fibrous sheath of mammalian spermatozoa by Eddy, Edward M., Toshimori, Kiyotaka, O'Brien, Deborah A.

“…The fibrous sheath is a unique cytoskeletal structure surrounding the axoneme and outer dense fibers and defines the extent of the principal piece region of…”
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Spermatogenic cell-specific type 1 hexokinase is the predominant hexokinase in sperm by Nakamura, Noriko, Shibata, Haruna, O'Brien, Deborah A., Mori, Chisato, Eddy, Edward M.

“…Hexokinase is the first enzyme in the glycolytic pathway and utilizes ATP to convert glucose to glucose‐6‐phosphate (G6P). We previously identified three…”
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CIB1 Is Essential for Mouse Spermatogenesis by Yuan, Weiping, Leisner, Tina M., McFadden, Andrew W., Clark, Shantres, Hiller, Sylvia, Maeda, Nobuyo, O'Brien, Deborah A., Parise, Leslie V.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Frequent and recent retrotransposition of orthologous genes plays a role in the evolution of sperm glycolytic enzymes by Vemuganti, Soumya A, de Villena, Fernando Pardo-Manuel, O'Brien, Deborah A

“…The central metabolic pathway of glycolysis converts glucose to pyruvate, with the net production of 2 ATP and 2 NADH per glucose molecule. Each of the ten…”
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Three male germline-specific aldolase A isozymes are generated by alternative splicing and retrotransposition by Vemuganti, Soumya A., Bell, Timothy A., Scarlett, Cameron O., Parker, Carol E., Pardo-Manuel de Villena, Fernando, O'Brien, Deborah A.

“…Enzymes in the glycolytic pathway of mammalian sperm are modified extensively and are localized in the flagellum, where several are tightly bound to the…”
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Metabolic Substrates Exhibit Differential Effects on Functional Parameters of Mouse Sperm Capacitation1 by Goodson, Summer G, Qiu, Yunping, Sutton, Keith A, Xie, Guoxiang, Jia, Wei, O'Brien, Deborah A

“…Although substantial evidence exists that sperm ATP production via glycolysis is required for mammalian sperm function and male fertility, conflicting reports…”
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Angiotensin-Converting Enzyme and Male Fertility by Hagaman, John R., Moyer, Jeffrey S., Bachman, Eric S., Sibony, Mathilde, Magyar, Patricia L., Welch, Jeffrey E., Smithies, Oliver, Krege, John H., O'Brien, Deborah A.

“…The angiotensin-convering enzyme (ACE; EC 3.4.15.1) gene (Ace) encodes both a somatic isozyme found in blood and several other tissues, including the…”
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A-kinase anchoring protein 4 has a conserved role in mammalian spermatogenesis by Hu, Yanqiu, Yu, Hongshi, Pask, Andrew J, O'Brien, Deborah A, Shaw, Geoff, Renfree, Marilyn B

“…A-kinase anchor protein 4 (AKAP4) is an X-linked member of the AKAP family of scaffold proteins that anchor cAMP-dependent protein kinases and play an…”
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Classification of Mouse Sperm Motility Patterns Using an Automated Multiclass Support Vector Machines Model1 by Goodson, Summer G, Zhang, Zhaojun, Tsuruta, James K, Wang, Wei, O'Brien, Deborah A

“…Vigorous sperm motility, including the transition from progressive to hyperactivated motility that occurs in the female reproductive tract, is required for…”
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Classification of Mouse Sperm Motility Patterns Using an Automated Multiclass Support Vector Machines Model by GOODSON, Summer G, ZHAOJUN ZHANG, TSURUTA, James K, WEI WANG, O'BRIEN, Deborah A

“…Vigorous sperm motility, including the transition from progressive to hyperactivated motility that occurs in the female reproductive tract, is required for…”
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Bicarbonate-Induced phosphorylation of p270 protein in mouse sperm by cAMP-Dependent protein kinase by Kaneto, Masako, Krisfalusi, Michelle, Eddy, Edward M., O'Brien, Deborah A., Miki, Kiyoshi

“…Signaling by cAMP‐dependent protein kinase (PKA) plays an important role in the regulation of mammalian sperm motility. However, it has not been determined how…”
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Failure of spermatogenesis in mouse lines deficient in the Na(+)-K(+)-2Cl(-) cotransporter by Pace, A J, Lee, E, Athirakul, K, Coffman, T M, O'Brien, D A, Koller, B H

“…The Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) carries 1 molecule of Na(+) and K(+) along with 2 molecules of Cl(-) across the cell membrane. It is expressed in a…”
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Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross by Shorter, John R, Odet, Fanny, Aylor, David L, Pan, Wenqi, Kao, Chia-Yu, Fu, Chen-Ping, Morgan, Andrew P, Greenstein, Seth, Bell, Timothy A, Stevans, Alicia M, Feathers, Ryan W, Patel, Sunny, Cates, Sarah E, Shaw, Ginger D, Miller, Darla R, Chesler, Elissa J, McMillian, Leonard, O'Brien, Deborah A, Villena, Fernando Pardo-Manuel de

“…The goal of the Collaborative Cross (CC) project was to generate and distribute over 1000 independent mouse recombinant inbred strains derived from eight…”
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Recombinant human sperm-specific glyceraldehyde-3-phosphate dehydrogenase (GAPDHS) is expressed at high yield as an active homotetramer in baculovirus-infected insect cells by Lamson, David R., House, Alan J., Danshina, Polina V., Sexton, Jonathan Z., Sanyang, Khaddijatou, O’Brien, Deborah A., Yeh, Li-An, Williams, Kevin P.

“…The sperm-specific glyceraldehyde-3-phosphate dehydrogenase (GAPDHS) isoform is a promising contraceptive target because it is specific to male germ cells,…”
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Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis by Welch, Jeffrey E., Barbee, Randy R., Magyar, Patricia L., Bunch, Donna O., O'Brien, Deborah A.

“…The spermatogenic cell‐specific variant of glyceraldehyde 3‐phosphate dehydrogenase (GAPDS) has been cloned from a rat testis cDNA library and its pattern of…”
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CASAnova: A multiclass support vector machine model for the classification of human sperm motility patterns by Goodson, Summer G, White, Sarah, Stevans, Alicia M, Bhat, Sanjana, Kao, Chia-Yu, Jaworski, Scott, Marlowe, Tamara R, Kohlmeier, Martin, McMillan, Leonard, Zeisel, Steven H, O'Brien, Deborah A

“…The ability to accurately monitor alterations in sperm motility is paramount to understanding multiple genetic and biochemical perturbations impacting normal…”
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Metabolic Substrates Exhibit Differential Effects on Functional Parameters of Mouse Sperm Capacitation by GOODSON, Summer G, YUNPING QIU, SUTTON, Keith A, GUOXIANG XIE, WEI JIA, O'BRIEN, Deborah A

“…Although substantial evidence exists that sperm ATP production via glycolysis is required for mammalian sperm function and male fertility, conflicting reports…”
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