Search Results - "O'BRIEN, Bronwyn A"

The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus by Lund, Maria E., To, Joyce, O'Brien, Bronwyn A., Donnelly, Sheila

“…The human monocytic cell line, THP-1, is the most widely used model for primary human monocytes/macrophages. This is because, following differentiation using…”
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The immune modulatory peptide FhHDM‐1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages by Alvarado, Raquel, To, Joyce, Lund, Maria E., Pinar, Anita, Mansell, Ashley, Robinson, Mark W., O'Brien, Bronwyn A., Dalton, John P., Donnelly, Sheila

“…The NLRP3 inflammasome is a multimeric protein complex that controls the production of IL‐1β, a cytokine that influences the development of both innate and…”
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Single-cell analysis of the T-cell receptor repertoire in untreated myeloma patients suggests potential myeloma-reactive CD8+ T-cells are shared between blood and marrow by Favaloro, James, Bryant, Christian E, Abadir, Edward, Gardiner, Samuel, Yang, Shihong, King, Tracy, Nassif, Najah, O'Brien, Bronwyn A, Sedger, Lisa M, Boyle, Richard, Joshua, Douglas E, Ho, P Joy

“…Not available.Not available…”
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Neonatal Rats Exhibit a Predominantly Anti-Inflammatory Response following Spinal Cord Injury by Sutherland, Theresa C, Ricafrente, Alison, Gomola, Katarina, O'Brien, Bronwyn A, Gorrie, Catherine A

“…It has been reported that children may respond better than adults to a spinal cord injury (SCI) of similar severity. There are known biomechanical differences…”
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Pancreatic Transdifferentiation Using β-Cell Transcription Factors for Type 1 Diabetes Treatment by Mahoney, Alexandra L. G., Nassif, Najah T., O’Brien, Bronwyn A., Simpson, Ann M.

“…Type 1 diabetes is a chronic illness in which the native beta (β)-cell population responsible for insulin release has been the subject of autoimmune…”
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A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis by Lund, Maria E., Greer, Judith, Dixit, Aakanksha, Alvarado, Raquel, McCauley-Winter, Padraig, To, Joyce, Tanaka, Akane, Hutchinson, Andrew T., Robinson, Mark W., Simpson, Ann M., O’Brien, Bronwyn A., Dalton, John P., Donnelly, Sheila

“…Helminth parasites secrete molecules that potently modulate the immune responses of their hosts and, therefore, have potential for the treatment of…”
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Secreted proteins from the helminth Fasciola hepatica inhibit the initiation of autoreactive T cell responses and prevent diabetes in the NOD mouse by Lund, Maria E, O'Brien, Bronwyn A, Hutchinson, Andrew T, Robinson, Mark W, Simpson, Ann M, Dalton, John P, Donnelly, Sheila

“…Infections with helminth parasites prevent/attenuate auto-inflammatory disease. Here we show that molecules secreted by a helminth parasite could prevent Type…”
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Fasciola hepatica: The therapeutic potential of a worm secretome by Robinson, Mark W., Dalton, John P., O’Brien, Bronwyn A., Donnelly, Sheila

“…[Display omitted] ► Within hours of infection, Fasciola hepatica suppresses host protective immune responses. ► Administration of Fasciola excretory/secretory…”
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Use of a Hybrid Adeno-Associated Viral Vector Transposon System to Deliver the Insulin Gene to Diabetic NOD Mice by La, Que T, Ren, Binhai, Logan, Grant J, Cunningham, Sharon C, Khandekar, Neeta, Nassif, Najah T, O'Brien, Bronwyn A, Alexander, Ian E, Simpson, Ann M

“…Previously, we used a lentiviral vector to deliver furin-cleavable human insulin ( ) to the livers in several animal models of diabetes using intervallic…”
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Pancreatic Transdifferentiation and Glucose-Regulated Production of Human Insulin in the H4IIE Rat Liver Cell Line by Ren, Binhai, Tao, Chang, Swan, Margaret Anne, Joachim, Nichole, Martiniello-Wilks, Rosetta, Nassif, Najah T, O'Brien, Bronwyn A, Simpson, Ann M

“…Due to the limitations of current treatment regimes, gene therapy is a promising strategy being explored to correct blood glucose concentrations in diabetic…”
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Phagocytosis of Apoptotic Cells by Macrophages From NOD Mice Is Reduced by O’Brien, Bronwyn A., Huang, Yongqian, Geng, Xuan, Dutz, Jan P., Finegood, Diane T.

“…Phagocytosis of Apoptotic Cells by Macrophages From NOD Mice Is Reduced Bronwyn A. O’Brien 1 , Yongqian Huang 1 , Xuan Geng 1 , Jan P. Dutz 2 and Diane T…”
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A deficiency in the in vivo clearance of apoptotic cells is a feature of the NOD mouse by O'Brien, Bronwyn A., Geng, Xuan, Orteu, Catherine H., Huang, Yongqian, Ghoreishi, Mehran, Zhang, YiQun, Bush, Jason A., Li, Gang, Finegood, Diane T., Dutz, Jan Peter

“…Deficiencies in apoptotic cell clearance have been linked to autoimmunity. Here we examined the time-course of peritoneal macrophage phagocytosis of dying…”
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Reversal of diabetes following transplantation of an insulin-secreting human liver cell line: Melligen cells by Lawandi, Janet, Tao, Chang, Ren, Binhai, Williams, Paul, Ling, Dora, Swan, M Anne, Nassif, Najah T, Torpy, Fraser R, O'Brien, Bronwyn A, Simpson, Ann M

“…As an alternative to the transplantation of islets, a human liver cell line has been genetically engineered to reverse type 1 diabetes (TID). The initial liver…”
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A helminth cathelicidin‐like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase by Robinson, Mark W., Alvarado, Raquel, To, Joyce, Hutchinson, Andrew T., Dowdell, Stephanie N., Lund, Maria, Turnbull, Lynne, Whitchurch, Cynthia B., O'Brien, Bronwyn A., Dalton, John P., Donnelly, Sheila

“…We previously reported the identification of a novel family of immunomodulatory proteins, termed helminth defense molecules (HDMs), that are secreted by…”
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1778-P: Delivery of the Insulin Gene Using an Integrating Adeno-Associated Viral Vector (AAV) to Diabetic NOD Mice by LA, QUE T., REN, BINHAI, LOGAN, GRANT J., CUNNINGHAM, SHARON C., KHANDEKAR, NEETA, NASSIF, NAJAH T., O'BRIEN, BRONWYN A., ALEXANDER, IAN E., SIMPSON, ANN M.

“…Previously we introduced furin-cleavable human insulin (INSFUR) to the livers in several animal models using a lentiviral vector. Reversal of diabetes with…”
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Partial pancreatic transdifferentiation of primary human hepatocytes in the livers of a humanised mouse model by Ren, Binhai, La, Que T., O'Brien, Bronwyn A., Nassif, Najah T., Tan, Yi, Gerace, Dario, Martiniello‐Wilks, Rosetta, Torpy, Fraser, Dane, Allison P., Alexander, Ian E., Simpson, Ann M.

“…Background Gene therapy is one treatment that may ultimately cure type 1 diabetes. We have previously shown that the introduction of furin‐cleavable human…”
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Long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy by Ren, Binhai, O'Brien, Bronwyn A., Byrne, Michelle R., Ch'ng, Edwin, Gatt, Prudence N., Swan, M. Anne, Nassif, Najah T., Wei, Ming Q., Gijsbers, Rik, Debyser, Zeger, Simpson, Ann M.

“…Background Type 1 diabetes (T1D) results from an autoimmune attack against the insulin‐producing β‐cells of the pancreas. The present study aimed to reverse…”
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Response to the letter to the editor by M. Elsner et al: "Comment on Binhai Ren et al (2013;15:28-41). Long term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy" by Simpson, Ann M., Ren, Binhai, O'Brien, Bronwyn A., Nassif, Najah T.

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Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse by O'BRIEN, B. A, HARMON, B. V, CAMERON, D. P, ALLAN, D. J

“…The NOD/Lt mouse, a widely used model of human autoimmune IDDM, was used to establish the mode of beta-cell death responsible for the development of IDDM…”
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Association of SLC11A1 promoter polymorphisms with the incidence of autoimmune and inflammatory diseases: A meta-analysis by O'Brien, Bronwyn A, Archer, Nicholas S, Simpson, Ann M, Torpy, Fraser R, Nassif, Najah T

“…Abstract Solute carrier family 11 member a1 ( SLC11A1 ) exerts pleiotropic effects on macrophage function. Expression of SLC11A1 is regulated by a (GT)n…”
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