Search Results - "Nyström, Susanne"

The Liver and Kidneys mediate clearance of cardiac troponin in the rat by Muslimovic, Aida, Fridén, Vincent, Tenstad, Olav, Starnberg, Karin, Nyström, Susanne, Wesén, Emelie, Esbjörner, Elin K., Granholm, Kristoffer, Lindahl, Bertil, Hammarsten, Ola

“…Cardiac-specific troponins (cTn), troponin T (cTnT) and troponin I (cTnI) are diagnostic biomarkers when myocardial infarction is suspected. Despite its…”
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A Possible Mechanism behind Faster Clearance and Higher Peak Concentrations of Cardiac Troponin I Compared with Troponin T in Acute Myocardial Infarction by Starnberg, Karin, Fridén, Vincent, Muslimovic, Aida, Ricksten, Sven-Erik, Nyström, Susanne, Forsgard, Niklas, Lindahl, Bertil, Vukusic, Kristina, Sandstedt, Joakim, Dellgren, Göran, Hammarsten, Ola

“…Although cardiac troponin I (cTnI) and troponin T (cTnT) form a complex in the human myocardium and bind to thin filaments in the sarcomere, cTnI often reaches…”
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Numerical analysis of etoposide induced DNA breaks by Muslimović, Aida, Nyström, Susanne, Gao, Yue, Hammarsten, Ola

“…Etoposide is a cancer drug that induces strand breaks in cellular DNA by inhibiting topoisomerase II (topoII) religation of cleaved DNA molecules. Although DNA…”
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Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target by Cummings, Maxwell D, Lindberg, Jimmy, Lin, Tse -I, de Kock, Herman, Lenz, Oliver, Lilja, Elisabet, Felländer, Sara, Baraznenok, Vera, Nyström, Susanne, Nilsson, Magnus, Vrang, Lotta, Edlund, Michael, Rosenquist, Åsa, Samuelsson, Bertil, Raboisson, Pierre, Simmen, Kenneth

“…If the shoe fits: TMC435, a noncovalent small‐molecule inhibitor of the hepatitis C virus (HCV) NS3/NS4A protease, is currently undergoing clinical evaluation…”
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Effect of the Protonation State of the Titratable Residues on the Inhibitor Affinity to BACE-1 by Domínguez, José L, Christopeit, Tony, Villaverde, M. Carmen, Gossas, Thomas, Otero, José M, Nyström, Susanne, Baraznenok, Vera, Lindström, Erik, Danielson, U. Helena, Sussman, Fredy

“…BACE-1 is one of the aspartic proteases involved in the cleavage of β amyloid peptide, an initial step in the formation of amyloid plaques whose toxicity…”
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Novel clearance of muscle proteins by muscle cells by Muslimovic, Aida, Fridén, Vincent, Starnberg, Karin, Tenstad, Olav, Espedal, Heidi, Vukusic, Kristina, Nyström, Susanne, Wesén, Emelie, Esbjörner, Elin K., Granholm, Kristoffer, Lindahl, Bertil, Hammarsten, Ola

“…[Display omitted] •Muscle proteins are taken up locally by muscle cells.•Novel mechanism for clearance of muscle proteins by muscle cells.•Local clearance of…”
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Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library by Nordström, Helena, Gossas, Thomas, Hämäläinen, Markku, Källblad, Per, Nyström, Susanne, Wallberg, Hans, Danielson, U. Helena

“…Small inhibitors of matrix metalloproteinase 12 (MMP-12) have been identified with a biosensor-based screening strategy and a specifically designed fragment…”
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Deletion of Neuropeptide Y (NPY) 2 Receptor in Mice Results in Blockage of NPY-Induced Angiogenesis and Delayed Wound Healing by Ekstrand, A. Jonas, Cao, Renhai, Björndahl, Meit, Nyström, Susanne, Jönsson-Rylander, Ann-Cathrine, Hassani, Hessameh, Hallberg, Bengt, Nordlander, Margareta, Cao, Yihai

“…Neuropeptide Y (NPY), a 36-aa peptide, is widely distributed in the brain and peripheral tissues. Whereas physiological roles of NPY as a…”
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A surface plasmon resonance-based biosensor with full-length BACE1 in a reconstituted membrane by Christopeit, Tony, Stenberg, Gun, Gossas, Thomas, Nyström, Susanne, Baraznenok, Vera, Lindström, Erik, Danielson, U. Helena

“…A surface plasmon resonance (SPR) biosensor-based assay for membrane-embedded full-length BACE1 (β-site amyloid precursor protein cleaving enzyme 1), a drug…”
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The expression of nerve growth factor in healthy and inflamed equine chondrocytes analysed by capillary western immunoassay by Nyström, Susanne, Kendall, Anna, Adepu, Saritha, Lindahl, Anders, Skiöldebrand, Eva

“…Nerve Growth Factor (NGF) is a signalling molecule for pain and inflammation. NGF is increased in synovial fluid from osteoarthritic humans and animals,…”
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Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: Exploration of P1 phenoxy and benzyloxy residues by Bäck, Marcus, Nyhlén, Jonas, Kvarnström, Ingemar, Appelgren, Sara, Borkakoti, Neera, Jansson, Katarina, Lindberg, Jimmy, Nyström, Susanne, Hallberg, Anders, Rosenquist, Åsa, Samuelsson, Bertil

“…Several BACE-1 inhibitors with low nanomolar level activities, encompassing a statine-based core structure with phenyloxymethyl- and benzyloxymethyl residues…”
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Differences in Surface-Exposed Antigen Expression between Helicobacter pylori Strains Isolated from Duodenal Ulcer Patients and from Asymptomatic Subjects by THORESON, A.-C. E, HAMLET, A, CELIK, J, BYSTRÖM, M, NYSTRÖM, S, OLBE, L, SVENNERHOLM, A.-M

“…Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Recombinant HpaA purified from Escherichia coli has biological properties similar to those of native Helicobacter pylori HpaA by Lundstrom, Anneli M, Bolin, Ingrid, Bystrom, Mona, Nystrom, Susanne

“…The aim of this study was to recombinantly produce and purify Helicobacter pylori adhesin A (HpaA) from Escherichia coli and compare it to purified native H…”
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Berichtigung: Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target by Cummings, Maxwell D., Lindberg, Jimmy, Lin, Tse-I, de Kock, Herman, Lenz, Oliver, Lilja, Elisabet, Felländer, Sara, Baraznenok, Vera, Nyström, Susanne, Nilsson, Magnus, Vrang, Lotta, Edlund, Michael, Rosenquist, Åsa, Samuelsson, Bertil, Raboisson, Pierre, Simmen, Kenneth

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Innentitelbild: Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target (Angew. Chem. 9/2010) by Cummings, Maxwell D., Lindberg, Jimmy, Lin, Tse-I, de Kock, Herman, Lenz, Oliver, Lilja, Elisabet, Felländer, Sara, Baraznenok, Vera, Nyström, Susanne, Nilsson, Magnus, Vrang, Lotta, Edlund, Michael, Rosenquist, Åsa, Samuelsson, Bertil, Raboisson, Pierre, Simmen, Kenneth

“…Die Anti‐HCV‐Aktivität des Wirkstoffs TMC435, der sich gegenwärtig in klinischen Phase‐2b‐Studien befindet, beruht auf der Hemmung der NS3/4A‐Protease des…”
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Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? A Case Study of Metalloproteinases by Isaksson, Johan, Nyström, Susanne, Derbyshire, Dean, Wallberg, Hans, Agback, Tatiana, Kovacs, Helena, Bertini, Ivano, Giachetti, Andrea, Luchinat, Claudio

“…A human matrix metalloproteinase (MMP) hydroxamic acid inhibitor (CGS27023A) was cross-docked into 15 MMP-12, MMP-13, MMP-9, and MMP-1 cocrystal structures…”
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A randomized, triple-blinded controlled clinical study with a novel disease-modifying drug combination in equine lameness-associated osteoarthritis by Skiöldebrand, E., Adepu, S., Lützelschwab, C., Nyström, S., Lindahl, A., Abrahamsson-Aurell, K., Hansson, E.

“…This study aimed to test a novel treatment combination (TC) (equivalent to sildenafil, mepivacaine, and glucose) with disease-modifying properties compared to…”
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Induced‐Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target by Cummings, Maxwell D., Lindberg, Jimmy, Lin, Tse‐I, de Kock, Herman, Lenz, Oliver, Lilja, Elisabet, Felländer, Sara, Baraznenok, Vera, Nyström, Susanne, Nilsson, Magnus, Vrang, Lotta, Edlund, Michael, Rosenquist, Åsa, Samuelsson, Bertil, Raboisson, Pierre, Simmen, Kenneth

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Salivary biglycan-neo-epitope-BGN262: A novel surrogate biomarker for equine osteoarthritic sub-chondral bone sclerosis and to monitor the effect of short-term training and surface arena by Adepu, S., Lord, M., Hugoh, Z., Nyström, S., Mattsson-Hulten, L., Abrahamsson-Aurell, K., Lützelschwab, C., Skiöldebrand, E.

“…We aimed to delineate a novel soluble Biglycan Neo-epitope-BGN262 in saliva from young reference and osteoarthritic horses in conjunction with the influence of…”
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Activation of Ataxia Telangiectasia Mutated by DNA Strand Break-inducing Agents Correlates Closely with the Number of DNA Double Strand Breaks by Ismail, Ismail Hassan, Nyström, Susanne, Nygren, Jonas, Hammarsten, Ola

“…The protein kinase ataxia telangiectasia mutated (ATM) is activated when cells are exposed to ionizing radiation (IR). It has been assumed that ATM is…”
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