Search Results - "Nymo, Stig"

Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release by Samstad, Eivind O, Niyonzima, Nathalie, Nymo, Stig, Aune, Marie H, Ryan, Liv, Bakke, Siril S, Lappegård, Knut T, Brekke, Ole-Lars, Lambris, John D, Damås, Jan K, Latz, Eicke, Mollnes, Tom E, Espevik, Terje

“…Inflammation is associated with development of atherosclerosis, and cholesterol crystals (CC) have long been recognized as a hallmark of atherosclerotic…”
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Properdin binding to complement activating surfaces depends on initial C3b deposition by Harboe, Morten, Johnson, Christina, Nymo, Stig, Ekholt, Karin, Schjalm, Camilla, Lindstad, Julie K., Pharo, Anne, Hellerud, Bernt Christian, Ekdahl, Kristina Nilsson, Mollnes, Tom Eirik, Nilsson, Per H.

“…Two functions have been assigned to properdin; stabilization of the alternative convertase, C3bBb, is well accepted, whereas the role of properdin as pattern…”
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Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF by Nymo, Stig, Niyonzima, Nathalie, Espevik, Terje, Mollnes, Tom Eirik

“…Abstract Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty…”
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Human Endothelial Cell Activation by Escherichia coli and Staphylococcus aureus Is Mediated by TNF and IL-1β Secondarily to Activation of C5 and CD14 in Whole Blood by Nymo, Stig, Gustavsen, Alice, Nilsson, Per H, Lau, Corinna, Espevik, Terje, Mollnes, Tom Eirik

“…Endothelial cells (EC) play a central role in inflammation. E-selectin and ICAM-1 expression are essential for leukocyte recruitment and are good markers of EC…”
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Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4–MD2 Complex by Gustavsen, Alice, Nymo, Stig, Landsem, Anne, Christiansen, Dorte, Ryan, Liv, Husebye, Harald, Lau, Corinna, Pischke, Søren E., Lambris, John D., Espevik, Terje, Mollnes, Tom E.

“…Background. Single inhibition of the Toll-like receptor 4 (TLR4)–MD2 complex failed in treatment of sepsis. CD14 is a coreceptor for several TLRs, including…”
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The anti‐inflammatory effect of combined complement and CD14 inhibition is preserved during escalating bacterial load by Egge, Kjetil H., Barratt‐Due, Andreas, Nymo, Stig, Lindstad, Julie K., Pharo, Anne, Lau, Corinna, Espevik, Terje, Thorgersen, Ebbe B., Mollnes, Tom E.

“…Summary Combined inhibition of complement and CD14 is known to attenuate bacterial‐induced inflammation, but the dependency of the bacterial load on this…”
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Correction: Patient characteristics in sepsis-related deaths: prevalence of advanced frailty, comorbidity, and age in a Norwegian hospital trust by Torvik, Marianne Ask, Nymo, Stig Haugset, Nymo, Ståle Haugset, Bjørnsen, Lars Petter, Kvarenes, Hanne Winge, Ofstad, Eirik Hugaas

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Electrolyte imbalances in an unselected population in an emergency department: A retrospective cohort study by Tazmini, Kiarash, Nymo, Ståle H, Louch, William E, Ranhoff, Anette H, Øie, Erik

“…Although electrolyte imbalances (EIs) are common in the emergency department (ED), few studies have examined the occurrence of such conditions in an unselected…”
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Patient characteristics in sepsis-related deaths: prevalence of advanced frailty, comorbidity, and age in a Norwegian hospital trust by Torvik, Marianne Ask, Nymo, Stig Haugset, Nymo, Ståle Haugset, Bjørnsen, Lars Petter, Kvarenes, Hanne Winge, Ofstad, Eirik Hugaas

“…Objective To examine the prevalence of advanced frailty, comorbidity, and age among sepsis-related deaths in an adult hospital population. Methods…”
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A teenage girl who took a large quantity of tablets with suicidal intent by Skjeflo, Espen W, Nymo, Stig H, Djupen, Silje M, Hammervold, Rønnaug, Ofstad, Eirik H

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Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4 by Landsem, Anne, Fure, Hilde, Ludviksen, Judith K, Christiansen, Dorte, Lau, Corinna, Mathisen, Monica Dammen, Bergseth, Grete, Nymo, Stig Haugset, Lappegård, Knut Tore, Woodruff, T. M, Espevik, Terje, Mollnes, Tom Eirik, Brekke, Ole-Lars

“…There is a close cross‐talk between complement, Toll‐like receptors (TLRs) and coagulation. The role of the central complement component 5 (C5) in…”
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Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria by Berg, Aase, Otterdal, Kari, Patel, Sam, Gonca, Miguel, David, Catarina, Dalen, Ingvild, Nymo, Stig, Nilsson, Margareta, Nordling, Sofia, Magnusson, Peetra U., Ueland, Thor, Prato, Mauro, Giribaldi, Giuliana, Mollnes, Tom Eirik, Aukrust, Pål, Langeland, Nina, Nilsson, Per H.

“…The impact of complement activation and its possible relation to cytokine responses during malaria pathology was investigated in plasma samples from patients…”
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Combined inhibition of complement and CD14 attenuates bacteria-induced inflammation in human whole blood more efficiently than antagonizing the toll-like receptor 4-MD2 complex by Gustavsen, Alice, Nymo, Stig Haugset, Landsem, Anne, Christiansen, Dorte, Ryan, Liv, Husebye, Harald, Lau, Corinna, Pischke, Søren Erik, Lambris, John D, Espevik, Terje, Mollnes, Tom Eirik

“…Background Single inhibition of the Toll-like receptor 4 (TLR4)–MD2 complex failed in treatment of sepsis. CD14 is a coreceptor for several TLRs, including…”
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Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli‐induced coagulation accompanied by Toll‐like receptor 4 by Landsem, A., Fure, H., Krey Ludviksen, J., Christiansen, D., Lau, C., Mathisen, M., Bergseth, G., Nymo, S., Lappegård, K. T., Woodruff, T. M., Espevik, T., Mollnes, T. E., Brekke, O.‐L.

“…Summary There is a close cross‐talk between complement, Toll‐like receptors (TLRs) and coagulation. The role of the central complement component 5 (C5) in…”
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Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: results of a 5-year follow-up cohort study by Siljan, William W, Holter, Jan C, Michelsen, Annika E, Nymo, Ståle H, Lauritzen, Trine, Oppen, Kjersti, Husebye, Einar, Ueland, Thor, Mollnes, Tom E, Aukrust, Pål, Heggelund, Lars

“…Biomarkers may facilitate clinical decisions in order to guide antimicrobial treatment and prediction of prognosis in community-acquired pneumonia (CAP). We…”
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En tenåringsjente med stort tablettinntak i suicidal hensikt by Skjeflo, Espen W., Nymo, Stig H., Djupen, Silje M., Hammervold, Rønnaug, Ofstad, Eirik H.

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Molecular modelling showed optimal fit between TSR5 in trimeric properdin and C345C in the C3b moiety for stabilization of the alternative convertase, whereas binding to molecular patterns in myeloperoxidase, endothelial cells and Neisseria meningitides was indirectly mediated by initial C3 activation by Harboe, Morten, Johnson, Christina, Nymo, Stig, Ekholt, Karin, Schjalm, Camilla, Lindstad, Julie K, Pharo, Anne, Hellerud, Bernt C, Ekdahl, Kristina N, Mollnes, Tom E, Nilsson, Per H

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Complement dependency of cholesterol crystal-induced inflammation – I. Pathway activation mechanisms, cytokine responses and endothelial cell activation by Nymo, Stig, Samstad, Eivind O, Niyonzima, Nathalie, Bergseth, Grethe, Christiansen, Dorte, Ryan, Liv, Brekke, Ole-Lars, Lappegård, Knut Tore, Damås, Jan Kristian, Latz, Eicke, Lambris, John D, Espevik, Terje, Mollnes, Tom Eirik

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